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m^6A RNA甲基化在非小细胞肺癌中的研究进展 被引量:8
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作者 潘红丽 李雪冰 +2 位作者 陈琛 范亚光 周清华 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第11期961-969,共9页
m^6A修饰是真核生物mRNA中最丰富的修饰之一,该过程受m^6A甲基转移酶和去甲基化酶的共同调控。m^6A修饰后的RNA能够被m^6A识别蛋白特异性识别并结合,进而介导RNA的剪接、成熟、出核、降解和翻译等。目前国内外对于m^6A修饰及其相关蛋白... m^6A修饰是真核生物mRNA中最丰富的修饰之一,该过程受m^6A甲基转移酶和去甲基化酶的共同调控。m^6A修饰后的RNA能够被m^6A识别蛋白特异性识别并结合,进而介导RNA的剪接、成熟、出核、降解和翻译等。目前国内外对于m^6A修饰及其相关蛋白如何参与非小细胞肺癌发生发展的研究,主要集中于细胞恶性增殖、迁移、侵袭、转移和耐药等方面。m^6A修饰相关蛋白在肺癌组织标本和血液循环肿瘤细胞(circulating tumor cell, CTC)中表达异常,有望成为肺癌诊断和预后判断的潜在分子标志物。本文围绕m^6A修饰相关蛋白的组成、作用方式、在非小细胞肺癌恶性进展中的生物学功能,以及针对m^6A修饰的靶向治疗等方面的研究进展进行综述,旨在为非小细胞肺癌的早期临床诊断和靶向药物的开发提供新思路。 展开更多
关键词 肺肿瘤 m^6A修饰 RNA甲基化 表观遗传修饰
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A Study of the Artificial Vegetation Restoration Technology in the Wenchuan Earthquake Area
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作者 Yu WANG Xingliang LIU +5 位作者 Anmin MIN Li WANG Wenbao MA hongli pan Hongxia LI Li ZHANG 《Asian Agricultural Research》 2014年第9期64-68,共5页
The situation of plants on the slope can reflect the effect of vegetation restoration during the process of artificial vegetation recovery.Taking the typical damaged slope of Wenchuan earthquake area as the research o... The situation of plants on the slope can reflect the effect of vegetation restoration during the process of artificial vegetation recovery.Taking the typical damaged slope of Wenchuan earthquake area as the research object,through observing the vegetation situation of deserted slope,the results show that compositae plants and gramineous plants are suitable for being pioneer plants and dominant in community; during the vegetation succession,many compositae and gramineous species invade,but there is no magaphanerophytes invading; as time goes by,the herbaceous species and diversity increase gradually,so the ecosystem becomes more stable and the gradient is important for the vegetation restoration. 展开更多
关键词 WENCHUAN EARTHQUAKE VEGETATION RESTORATION SPECIES
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Energy-Efficient Multi-Trip Routing for Municipal Solid Waste Collection by Contribution-Based Adaptive Particle Swarm Optimization 被引量:2
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作者 Xiaoning Shen hongli pan +3 位作者 Zhongpei Ge Wenyan Chen Liyan Song Shuo Wang 《Complex System Modeling and Simulation》 2023年第3期202-219,共18页
Waste collection is an important part of waste management system.Transportation costs and carbon emissions can be greatly reduced by proper vehicle routing.Meanwhile,each vehicle can work again after achieving its cap... Waste collection is an important part of waste management system.Transportation costs and carbon emissions can be greatly reduced by proper vehicle routing.Meanwhile,each vehicle can work again after achieving its capacity limit and unloading the waste.For this,an energy-efficient multi-trip vehicle routing model is established for municipal solid waste collection,which incorporates practical factors like the limited capacity,maximum working hours,and multiple trips of each vehicle.Considering both economy and environment,fixed costs,fuel costs,and carbon emission costs are minimized together.To solve the formulated model effectively,contribution-based adaptive particle swarm optimization is proposed.Four strategies named greedy learning,multi-operator learning,exploring learning,and exploiting learning are specifically designed with their own searching priorities.By assessing the contribution of each learning strategy during the process of evolution,an appropriate one is selected and assigned to each individual adaptively to improve the searching efficiency of the algorithm.Moreover,an improved local search operator is performed on the trips with the largest number of waste sites so that both the exploiting ability and the convergence accuracy of the algorithm are improved.Performance of the proposed algorithm is tested on ten waste collection instances,which include one real-world case derived from the Green Ring Company of Jiangbei New District,Nanjing,China,and nine synthetic instances with increasing scales generated from the commonly-used capacitated vehicle routing problem benchmark datasets.Comparisons with five state-of-the-art algorithms show that the proposed algorithm can obtain a solution with a higher accuracy for the constructed model. 展开更多
关键词 municipal solid waste collection energy conservation multi-trip CONTRIBUTION particle swarm optimization
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MouseVenue3D:A Markerless Three-Dimension Behavioral Tracking System for Matching Two-Photon Brain Imaging in Free-Moving Mice 被引量:1
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作者 Yaning Han Kang Huang +8 位作者 Ke Chen hongli pan Furong Ju Yueyue Long Gao Gao Runlong Wu Aimin Wang Liping Wang Pengfei Wei 《Neuroscience Bulletin》 SCIE CAS CSCD 2022年第3期303-317,共15页
Understanding the connection between brain and behavior in animals requires precise monitoring of their behaviors in three-dimensional(3-D)space.However,there is no available three-dimensional behavior capture system ... Understanding the connection between brain and behavior in animals requires precise monitoring of their behaviors in three-dimensional(3-D)space.However,there is no available three-dimensional behavior capture system that focuses on rodents.Here,we present MouseVenue3D,an automated and low-cost system for the efficient capture of 3-D skeleton trajectories in markerless rodents.We improved the most time-consuming step in 3-D behavior capturing by developing an automatic calibration module.Then,we validated this process in behavior recognition tasks,and showed that 3-D behavioral data achieved higher accuracy than 2-D data.Subsequently,MouseVenue3D was combined with fast high-resolution miniature two-photon microscopy for synchronous neural recording and behavioral tracking in the freely-moving mouse.Finally,we successfully decoded spontaneous neuronal activity from the 3-D behavior of mice.Our findings reveal that subtle,spontaneous behavior modules are strongly correlated with spontaneous neuronal activity patterns. 展开更多
关键词 Computational neuroethology Behavioral and neural recording 3-D pose estimation Multi-view cameras Automatic calibration
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