Multiple myeloma(MM)is an incurable malignancy of clonal plasma cells,characterized by high relapse rates and rapid development of drug resistance.The emergence of proteasome inhibitors has dramatically improved the t...Multiple myeloma(MM)is an incurable malignancy of clonal plasma cells,characterized by high relapse rates and rapid development of drug resistance.The emergence of proteasome inhibitors has dramatically improved the therapeutic effect of MM;however,side effects and drug resistance still negatively affect the survival rate of MM.Nano-medicine has become a promising field for therapeutic innovation owing to its biodegradability and biocompatibility.Nanoparticles(NPs),when combined with MM therapeutic drugs,can reduce side effects,increase treatment efficacy,and alleviate drug resistance,providing a new direction for the treatment of MM.Restructuring drugs with NPs presents an ideal strategy for ongoing studies aimed at more effective therapies.Additionally,clinical nanomedicine research has yielded new opportunities for MM treatment.This review,guided by the development of MM therapeutic drugs,summarizes the past 20 years of research progress and breakthroughs in NP-based systems for treating MM and improving drug targeting ability.展开更多
基金supported by the National Natural Science Foundation of China Youth Project(81900131)Tianjin Municipal Natural Science Foundation(18JCQNJC80400)+6 种基金Tianjin Education Commission Research Project(2018KJ043)Tianjin Education Commission Research Project(2018KJ045)Tianjin Science and Technology Planning Project(20YFZCSY00060)Tianjin Municipal Health Commission Youth Project(TJWJ2021QN001)the Medjaden Academy&Research Foundation for Young Scientists(MJR20221011)Tianjin Key Medical Discipline(Specialty)Construction project(XZDXK-028A)Tianjin Municipal Health Health Science and Technology Project(TJWJ2023XK003).
文摘Multiple myeloma(MM)is an incurable malignancy of clonal plasma cells,characterized by high relapse rates and rapid development of drug resistance.The emergence of proteasome inhibitors has dramatically improved the therapeutic effect of MM;however,side effects and drug resistance still negatively affect the survival rate of MM.Nano-medicine has become a promising field for therapeutic innovation owing to its biodegradability and biocompatibility.Nanoparticles(NPs),when combined with MM therapeutic drugs,can reduce side effects,increase treatment efficacy,and alleviate drug resistance,providing a new direction for the treatment of MM.Restructuring drugs with NPs presents an ideal strategy for ongoing studies aimed at more effective therapies.Additionally,clinical nanomedicine research has yielded new opportunities for MM treatment.This review,guided by the development of MM therapeutic drugs,summarizes the past 20 years of research progress and breakthroughs in NP-based systems for treating MM and improving drug targeting ability.
