Fault diagnosis is vital in manufacturing system.However,the first step of the traditional fault diagnosis method is to process the signal,extract the features and then put the features into a selected classifier for ...Fault diagnosis is vital in manufacturing system.However,the first step of the traditional fault diagnosis method is to process the signal,extract the features and then put the features into a selected classifier for classification.The process of feature extraction depends on the experimenters’experience,and the classification rate of the shallow diagnostic model does not achieve satisfactory results.In view of these problems,this paper proposes a method of converting raw signals into twodimensional images.This method can extract the features of the converted two-dimensional images and eliminate the impact of expert’s experience on the feature extraction process.And it follows by proposing an intelligent diagnosis algorithm based on Convolution Neural Network(CNN),which can automatically accomplish the process of the feature extraction and fault diagnosis.The effect of this method is verified by bearing data.The influence of different sample sizes and different load conditions on the diagnostic capability of this method is analyzed.The results show that the proposed method is effective and can meet the timeliness requirements of fault diagnosis.展开更多
In the field of bone defect repair,3D printed scaffolds have the characteristics of personalized customization and accurate internal structure.However,how to construct a well-structured vascular network quickly and ef...In the field of bone defect repair,3D printed scaffolds have the characteristics of personalized customization and accurate internal structure.However,how to construct a well-structured vascular network quickly and effectively inside the scaffold is essential for bone repair after transplantation.Herein,inspired by the unique biological structure of“lotus seedpod”,hydrogel microspheres encapsulating deferoxamine(DFO)liposomes were prepared through microfluidic technology as“lotus seeds”,and skillfully combined with a three-dimensional(3D)printed bioceramic scaffold with biomimetic“lotus”biological structure which can internally grow blood vessels.In this composite scaffold system,DFO was effectively released by 36%in the first 6 h,which was conducive to promote the growth of blood vessels inside the scaffold quickly.In the following 7 days,the release rate of DFO reached 69%,which was fundamental in the formation of blood vessels inside the scaffold as well as osteogenic differentiation of bone mesenchymal stem cells(BMSCs).It was confirmed that the composite scaffold could significantly promote the human umbilical vein endothelial cells(HUVECs)to form the vascular morphology within 6 h in vitro.In vivo,the composite scaffold increased the expression of vascularization and osteogenic related proteins Hif1-α,CD31,OPN,and OCN in the rat femoral defect model,significantly cutting down the time of bone repair.To sum up,this“lotus seedpod”inspired porous bioceramic 3D printed scaffold with internal vascularization functionality has broad application prospects in the future.展开更多
基金co-supported by the National Natural Science Foundation of China(No.51775452)Fundamental Research Funds for the Central Universities,China(Nos.2682019CX35 and 2018GF02)Planning Project of Science&Technology Department of Sichuan Province,China(No.2019YFG0353).
文摘Fault diagnosis is vital in manufacturing system.However,the first step of the traditional fault diagnosis method is to process the signal,extract the features and then put the features into a selected classifier for classification.The process of feature extraction depends on the experimenters’experience,and the classification rate of the shallow diagnostic model does not achieve satisfactory results.In view of these problems,this paper proposes a method of converting raw signals into twodimensional images.This method can extract the features of the converted two-dimensional images and eliminate the impact of expert’s experience on the feature extraction process.And it follows by proposing an intelligent diagnosis algorithm based on Convolution Neural Network(CNN),which can automatically accomplish the process of the feature extraction and fault diagnosis.The effect of this method is verified by bearing data.The influence of different sample sizes and different load conditions on the diagnostic capability of this method is analyzed.The results show that the proposed method is effective and can meet the timeliness requirements of fault diagnosis.
基金This work was supported by the National Key R&D Program of China(2019YFA0112000)National Natural Science Foundation of China(51873107)+2 种基金Shanghai Municipal Health and Family Planning Commission(201840027)Shanghai Jiao Tong University“Medical and Research”Program(ZH2018ZDA04)The Project Supported by the Foundation of National Facility for Translational Medicine(Shanghai)(TMSK-2020-117).
文摘In the field of bone defect repair,3D printed scaffolds have the characteristics of personalized customization and accurate internal structure.However,how to construct a well-structured vascular network quickly and effectively inside the scaffold is essential for bone repair after transplantation.Herein,inspired by the unique biological structure of“lotus seedpod”,hydrogel microspheres encapsulating deferoxamine(DFO)liposomes were prepared through microfluidic technology as“lotus seeds”,and skillfully combined with a three-dimensional(3D)printed bioceramic scaffold with biomimetic“lotus”biological structure which can internally grow blood vessels.In this composite scaffold system,DFO was effectively released by 36%in the first 6 h,which was conducive to promote the growth of blood vessels inside the scaffold quickly.In the following 7 days,the release rate of DFO reached 69%,which was fundamental in the formation of blood vessels inside the scaffold as well as osteogenic differentiation of bone mesenchymal stem cells(BMSCs).It was confirmed that the composite scaffold could significantly promote the human umbilical vein endothelial cells(HUVECs)to form the vascular morphology within 6 h in vitro.In vivo,the composite scaffold increased the expression of vascularization and osteogenic related proteins Hif1-α,CD31,OPN,and OCN in the rat femoral defect model,significantly cutting down the time of bone repair.To sum up,this“lotus seedpod”inspired porous bioceramic 3D printed scaffold with internal vascularization functionality has broad application prospects in the future.