材料界的轻骑兵——环烯烃类共聚物

通过一名普通大学生在国庆期间的武汉之旅,描述了她与华为Mate 60、食品包装袋和医疗器械的几次偶遇,并借此以生动活泼的方式向读者介绍了环烯烃类共聚物(COC)材料及其在光学器件、塑料包装和生物医学领域的典型应用。

青霉素家族专访直播录

青霉素是世界上发现的第一种抗菌药,目前已发展为含有β-内酰胺结构的抗菌药家族,在临床上广泛使用。本文以直播专访录的形式介绍了青霉素家族及主要成员。通过青霉素家族成员代表与主持人的对话,向人们生动展示了青霉素家族成员的抗菌机制、作用特点和临床应用,以此促进人们进一步树立合理应用抗生素的健康意识。

基于金课标准的医学基础化学实验双语版教材设计与建设

高质量的教材是强化课程教学的基础,对培养创新型人才具有重要意义。本文立足金课建设,以学生核心素养培养为目标,将医学基础化学实验双语版教材结构设计为两大模块、四个层次,并融合线上、线下混合式教学模式,在提升教材高阶性、创新性及挑战度以达到金课标准等方面进行了积极探索。

Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients

Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome.