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Managing facial infiltrating lipomatosis associated with PIK3CA mutation:From surgery to targeted therapy
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作者 hongrui chen Bin Sun +2 位作者 Wei Gao chen Hua Xiaoxi Lin 《Chinese Journal Of Plastic and Reconstructive Surgery》 2023年第1期25-29,共5页
Facial infiltrating lipomatosis(FIL)is a congenital asymmetrical deformity of the maxillofacial region that can significantly affect a patient’s facial appearance and function.With the development of sequencing techn... Facial infiltrating lipomatosis(FIL)is a congenital asymmetrical deformity of the maxillofacial region that can significantly affect a patient’s facial appearance and function.With the development of sequencing technologies,PIK3CA mutations are considered among the potential etiologies of FIL.The management and treatment of FIL involves plastic surgery;more recently,an improved understanding of its pathogenesis has given rise to new treatment options,including targeted therapy.Here we report the clinical data of two patients diagnosed with FIL and present current curative concepts. 展开更多
关键词 Facial infiltrating lipomatosis PIK3CA mutations SURGERY Targeted therapy
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Vascular anomalies workshop held successfully at the 21st Shanghai International Conference of Plastic and Aesthetic Surgery
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作者 Shih-Jen Chang hongrui chen chen Hua 《Chinese Journal Of Plastic and Reconstructive Surgery》 2022年第3期146-148,共3页
July 20 and 21,2022,witnessed the highlight of the 21st Shanghai International Conference of Plastic and Aesthetic Surgery,a successful vascular anomalies workshop titled“Advancements in the Management of Vascular An... July 20 and 21,2022,witnessed the highlight of the 21st Shanghai International Conference of Plastic and Aesthetic Surgery,a successful vascular anomalies workshop titled“Advancements in the Management of Vascular Anomalies”at Shanghai Ninth People’s Hospital.The conference was graced by many renowned specialists and scholars from China and abroad who presented lectures and panels on cutting-edge debated concepts and technological progress in the field.Amid the coronavirus disease 2019(COVID-19)pandemic,specialists from numerous fields have delivered rich content in person and virtually to participants across China.Prof.Xiaoxi Lin’s team from Shanghai Ninth People’s Hospital,a leading center in the field of infantile hemangioma and vascular malformation in China,collaborated with colleagues on new developments using teaching and discussion. 展开更多
关键词 SURGERY WORKSHOP SPECIALISTS
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先天性上斜肌麻痹的上斜肌Guyton增强牵拉试验和眼球旋转牵拉试验特征 被引量:1
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作者 李月平 陈红芮 +3 位作者 顾诗宇 丁娟 张伟 赵堪兴 《中华眼科杂志》 CAS CSCD 北大核心 2023年第7期535-541,共7页
目的探讨先天性上斜肌麻痹(CSOP)患者上斜肌Guyton增强牵拉试验(FDT)和眼球旋转FDT的特征其与患者临床特征的相关性。方法横断面研究。纳入2021年9月至2022年3月于天津市眼科医院拟行斜视矫正手术的单眼CSOP患者和间歇性外斜视(IXT)患... 目的探讨先天性上斜肌麻痹(CSOP)患者上斜肌Guyton增强牵拉试验(FDT)和眼球旋转FDT的特征其与患者临床特征的相关性。方法横断面研究。纳入2021年9月至2022年3月于天津市眼科医院拟行斜视矫正手术的单眼CSOP患者和间歇性外斜视(IXT)患者。术前测量患者双眼黄斑中心凹-视盘几何中心夹角(FDA)及上斜肌最大横截面积(max-CSA)术中双眼行Guyton增强FDT和旋转FDT,对上斜肌松弛程度进行评价和比较。分析两种FDT的特征及其与垂直斜视度数、FDA、max-CSA的相关性。采用t检验、ANOVA检验、Tukey、Mann-WhitneyU检验和χ2检验进行统计学分析。结果纳入患者共42例(84只眼),其中IXT患者19例(38只眼),男10例,女9例,年龄7(7,8)岁;CSOP患者23例(46只眼,麻痹眼和非麻痹眼各23只眼),男13例,女10例,年龄8(4,8)岁。IXT和CSOP患者性别构成和年龄差异均无统计学意义(均P>0.05)。Guyton增强FDT测得CSOP患者麻痹眼、非麻痹眼和IXT患者双眼上斜肌松弛程度分别为(-2.52±1.20)、(-0.35±0.71)和(-0.03±0.16)级,差异有统计学意义(F=88.10,P<0.001)。旋转FDT测得CSOP患者麻痹眼、非麻痹眼和IXT患者双眼的眼球外旋角度分别为48.70°±9.67°、37.39°±5.40°和38.95°±2.88°,差异有统计学意义(F=16.67,P<0.001),内旋角度差异无统计学意义(F=2.36,P=0.100)。IXT患者与CSOP患者FDA分别为-12.11°±7.42°和-19.02°±4.95°,CSOP患者麻痹眼与非麻痹眼上斜肌max-CSA分别为(7.59±4.69)和(11.63±3.64)mm2,差异均有统计学意义(均P<0.001)。Guyton增强FDT测得上斜肌肌腱松弛程度分级与旋转FDT测得外旋角度呈负相关(r=-0.64,P=0.001),二者与上斜肌max-CSA分别呈正相关(r=0.45,P=0.030)和负相关(r=-0.52,P=0.011),但与垂直斜视度数(r=-0.12,P=0.579;r=0.33,P=0.126)和FDA(r=-0.02,P=0.921;r=-0.23,P=0.309)均无相关性。结论Guyton增强FDT和旋转FDT均可评价先天性上斜肌麻痹患者的上斜肌松弛程度,且二者与上斜肌形态变化具有相关性,但FDT不能反映患者的垂直和旋转斜视度数。 展开更多
关键词 斜视 动眼肌 眼肌麻痹 眼球运动 眼外科手术
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