In this paper, in order to design a cam mechanism be up to the mustard, a set of methods are put forward that using the Visual Basic programming language based on solidworks to draw cam contour line and then get its 3...In this paper, in order to design a cam mechanism be up to the mustard, a set of methods are put forward that using the Visual Basic programming language based on solidworks to draw cam contour line and then get its 3D models and generate the cam motion simulation by the solidworks motion. In the end, it’s proved that the cam designed though this method met the requirement.展开更多
Power inverter adopting virtual synchronous generator(VSG)control can provide inertia support for distributed generation systems.However,it cannot take into account the dynamic regulation characteristics of frequency....Power inverter adopting virtual synchronous generator(VSG)control can provide inertia support for distributed generation systems.However,it cannot take into account the dynamic regulation characteristics of frequency.Thus,when the system encounters a sudden change in load or disturbance,the dynamic process of frequency regulation will be greatly influenced.In view of this issue,an improved VSG control strategy based on a coordinated self-adaptive(CSA)method is proposed.The time domain analysis method is used to study the influences of virtual inertia and damping parameter perturbation on the system steady and dynamic performances.Furthermore,in order to make the control strategy suitable for large load changes and suppress frequency variations beyond the limit,the secondary frequency modulation is introduced into the control loop.Through the coordinated adaptive control of virtual inertia,virtual damping and frequency modulation,the dynamic performance of vSG frequency regulation can be obviously improved.Simulation and experiment results have verified the effectiveness of the proposed CSA control strategy.展开更多
Aeroallergen sensitization,mainly mediated by lung epithelium and dendritic cells(DCs),is integral to allergic asthma pathogenesis and progression.IL-10 has a dual role in immune responses,as it inhibits myeloid cell ...Aeroallergen sensitization,mainly mediated by lung epithelium and dendritic cells(DCs),is integral to allergic asthma pathogenesis and progression.IL-10 has a dual role in immune responses,as it inhibits myeloid cell activation but promotes B-cell responses and epithelial cell proliferation.Here,we report a proinflammatory function of B-cell-derived IL-10 modulated by Bcl-3 in allergic asthma.Specifically,Bcl-3^(−/−)mice showed elevated IL-10 levels and were found to be highly vulnerable to allergic asthma induced by house dust mites(HDMs).IL-10 had a positive correlation with the levels of the DC chemoattractant CCL-20 in HDM-sensitized mice and in patients with asthma and induced a selective increase in CCL-20 production by mouse lung epithelial cells.Blockade of IL-10 or IL-10 receptors during sensitization dampened both HDM-induced sensitization and asthma development.IL-10 levels peaked 4 h post sensitization with HDM and IL-10 was primarily produced by B cells under Bcl-3–Blimp-1–Bcl-6 regulation.Mice lacking B-cell-derived IL-10 displayed decreased lung epithelial CCL-20 production and diminished DC recruitment to the lungs upon HDM sensitization,thereby demonstrating resistance to HDM-induced asthma.Moreover,responses to HDM stimulation in Bcl-3^(−/−)mice lacking B-cell-derived IL-10 were comparable to those in Bcl-3^(+/+)mice.The results revealed an unexpected role of B-cell-derived IL-10 in promoting allergic sensitization and demonstrated that Bcl-3 prevents HDM-induced asthma by inhibiting B-cell-derived IL-10 production.Thus,targeting the Bcl-3/IL-10 axis to inhibit allergic sensitization is a promising approach for treating allergic asthma.展开更多
Solid-solution based luminescent materials have been widely explored due to their tunable optical properties in recent years. In this work, instead of more common cation-substitution approach, we investigated the lumi...Solid-solution based luminescent materials have been widely explored due to their tunable optical properties in recent years. In this work, instead of more common cation-substitution approach, we investigated the luminescence properties of Eu^2＋ and Mn^2 ＋ co-doped halophosphate solid solution Ca5（PO4）3（F0.8Cl0.2） via anion substitution synthesized by high temperature solid state reaction method. The formation of the solid solution was confirmed by X-ray diffraction （XRD） characterization, which indicates that the introduction of certain proportion of CI will not make significant change on the CaB（PO4）3F lattice, We also studied the energy transfer from Eu^2＋ to Mn^2＋ in the host so as to obtain white light emission via adjusting the doping concentrations of Eu^2＋ and Mn^2＋, The white light emission was achieved through combination of Eu^2＋ blue emission and Mn^2＋ red-orange emission with appropriate proportions. The results suggest that Ca5（PO4）3（F0.8Cl0.2）：0.01Eu^2＋＋,0.18Mn^2＋ could be a potential WLED phosphor working under ultraviolet excitation,展开更多
The dynamic model for a bidirectional driven float-type wave power generation system design is presented in this paper.The gravity,buoyancy and drag force acting on the wave energy converter(WEC)are all analyzed.The a...The dynamic model for a bidirectional driven float-type wave power generation system design is presented in this paper.The gravity,buoyancy and drag force acting on the wave energy converter(WEC)are all analyzed.The analytical expression of the torque applied on the rotor is given based on a linear model of the switched reluctance generator(SRG).The SRG usually rotates with low velocity in the WEC system.In this situation,current chopping control(CCC)is adopted with fixed turn-on angle and turn-off angle control mode to have a quick response for SRG.Further,in order to make the float keep in phase with the wave so as to improve the power generation efficiency,the reference current is dynamically adjusted according to the wave motion at all working stages.Then maximum power point tracking(MPPT)of system is achieved.A simulation model is developed in MATLAB for the bidirectional driven float-type wave power generation system with real wave statistical characteristics taken into account.Simulation results show that the WEC can output desired torque periodically with high efficiency and good adaptability.Therefore,the feasibility of applying a SRG in a WEC is also verified.展开更多
文摘In this paper, in order to design a cam mechanism be up to the mustard, a set of methods are put forward that using the Visual Basic programming language based on solidworks to draw cam contour line and then get its 3D models and generate the cam motion simulation by the solidworks motion. In the end, it’s proved that the cam designed though this method met the requirement.
基金supported by National Natural Science Foundation of China(No.51577124,No.51877148)National Key Research and Development Program of China(SQ2023YFE0198100)。
文摘Power inverter adopting virtual synchronous generator(VSG)control can provide inertia support for distributed generation systems.However,it cannot take into account the dynamic regulation characteristics of frequency.Thus,when the system encounters a sudden change in load or disturbance,the dynamic process of frequency regulation will be greatly influenced.In view of this issue,an improved VSG control strategy based on a coordinated self-adaptive(CSA)method is proposed.The time domain analysis method is used to study the influences of virtual inertia and damping parameter perturbation on the system steady and dynamic performances.Furthermore,in order to make the control strategy suitable for large load changes and suppress frequency variations beyond the limit,the secondary frequency modulation is introduced into the control loop.Through the coordinated adaptive control of virtual inertia,virtual damping and frequency modulation,the dynamic performance of vSG frequency regulation can be obviously improved.Simulation and experiment results have verified the effectiveness of the proposed CSA control strategy.
基金We thank Dr.Mingfang Lu,Dr.Wei Jiang,Dr.Guohong Hu,Dr.Jin Li,and Dr.Xubo Huang for providing advice as well as some reagents used in this study.We appreciate Dr.Michael Reth and Dr.Axel Roers for gifting Il10fl/fl and Mb1-Cre mice.This investigation was funded by the National Natural Science Foundation of China(grants 81901633 to GQ and 91949102 to XZ)the National Program on Key Research(2021YFA0804703 to XZ)the Discipline Construction Projects of Guangzhou Medical University(02-445-2301246XM to XZ).
文摘Aeroallergen sensitization,mainly mediated by lung epithelium and dendritic cells(DCs),is integral to allergic asthma pathogenesis and progression.IL-10 has a dual role in immune responses,as it inhibits myeloid cell activation but promotes B-cell responses and epithelial cell proliferation.Here,we report a proinflammatory function of B-cell-derived IL-10 modulated by Bcl-3 in allergic asthma.Specifically,Bcl-3^(−/−)mice showed elevated IL-10 levels and were found to be highly vulnerable to allergic asthma induced by house dust mites(HDMs).IL-10 had a positive correlation with the levels of the DC chemoattractant CCL-20 in HDM-sensitized mice and in patients with asthma and induced a selective increase in CCL-20 production by mouse lung epithelial cells.Blockade of IL-10 or IL-10 receptors during sensitization dampened both HDM-induced sensitization and asthma development.IL-10 levels peaked 4 h post sensitization with HDM and IL-10 was primarily produced by B cells under Bcl-3–Blimp-1–Bcl-6 regulation.Mice lacking B-cell-derived IL-10 displayed decreased lung epithelial CCL-20 production and diminished DC recruitment to the lungs upon HDM sensitization,thereby demonstrating resistance to HDM-induced asthma.Moreover,responses to HDM stimulation in Bcl-3^(−/−)mice lacking B-cell-derived IL-10 were comparable to those in Bcl-3^(+/+)mice.The results revealed an unexpected role of B-cell-derived IL-10 in promoting allergic sensitization and demonstrated that Bcl-3 prevents HDM-induced asthma by inhibiting B-cell-derived IL-10 production.Thus,targeting the Bcl-3/IL-10 axis to inhibit allergic sensitization is a promising approach for treating allergic asthma.
基金supported by the National Key R&D Program of China(2017YFA0305400 and 2019YFA0704900)Chinese Academy of Sciences-Shanghai Science Research Center(CAS-SSRC-YH2015-01)+9 种基金Double First-Class Initiative Fund of Shanghai Tech Universitythe support from the Engineering and Physical Sciences Research Council Platform Grant(EP/M020517/1)the Major Research Plan of the National Natural Science Foundation of China(NSFC,92065201)Shanghai Municipal Science and Technology Major Project(2018SHZDZX02)the support from the NSFC(52088101 and 11974394)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(XDB33000000)the support from Shanghai Committee of Science and Technology(22ZR1441800)Shanghai-XFEL Beamline Project(SBP)(31011505505885920161A2101001)the support from the NSFC(12004248)and the support from the NSFC(12104304)Shanghai Sailing Program(20YF1430500)。
基金Project supported by the National Natural Science Foundation of China(11574298,61635012)the National Key Research and Development Program of China(2016YFB0701001)
文摘Solid-solution based luminescent materials have been widely explored due to their tunable optical properties in recent years. In this work, instead of more common cation-substitution approach, we investigated the luminescence properties of Eu^2＋ and Mn^2 ＋ co-doped halophosphate solid solution Ca5（PO4）3（F0.8Cl0.2） via anion substitution synthesized by high temperature solid state reaction method. The formation of the solid solution was confirmed by X-ray diffraction （XRD） characterization, which indicates that the introduction of certain proportion of CI will not make significant change on the CaB（PO4）3F lattice, We also studied the energy transfer from Eu^2＋ to Mn^2＋ in the host so as to obtain white light emission via adjusting the doping concentrations of Eu^2＋ and Mn^2＋, The white light emission was achieved through combination of Eu^2＋ blue emission and Mn^2＋ red-orange emission with appropriate proportions. The results suggest that Ca5（PO4）3（F0.8Cl0.2）：0.01Eu^2＋＋,0.18Mn^2＋ could be a potential WLED phosphor working under ultraviolet excitation,
基金supported by National Natural Science Foundation of China (No.51577124)the Key Technologies Research and Develop Program of Tianjin (No.15ZCZDGX00980)Tianjin Research Program of Application Foundation and Advanced Technology (No.15JCZDJC32100)
文摘The dynamic model for a bidirectional driven float-type wave power generation system design is presented in this paper.The gravity,buoyancy and drag force acting on the wave energy converter(WEC)are all analyzed.The analytical expression of the torque applied on the rotor is given based on a linear model of the switched reluctance generator(SRG).The SRG usually rotates with low velocity in the WEC system.In this situation,current chopping control(CCC)is adopted with fixed turn-on angle and turn-off angle control mode to have a quick response for SRG.Further,in order to make the float keep in phase with the wave so as to improve the power generation efficiency,the reference current is dynamically adjusted according to the wave motion at all working stages.Then maximum power point tracking(MPPT)of system is achieved.A simulation model is developed in MATLAB for the bidirectional driven float-type wave power generation system with real wave statistical characteristics taken into account.Simulation results show that the WEC can output desired torque periodically with high efficiency and good adaptability.Therefore,the feasibility of applying a SRG in a WEC is also verified.
