In the present study,we aimed to investigate the protective effect of Yuebi Jiazhu Decoction(YBJZD)on the kidney of adriamycin nephropathy(AN)rats.Rats were injected with adriamycin for modeling,except for the control...In the present study,we aimed to investigate the protective effect of Yuebi Jiazhu Decoction(YBJZD)on the kidney of adriamycin nephropathy(AN)rats.Rats were injected with adriamycin for modeling,except for the control group.After the successful establishment of the animal model,rats were randomly divided into the model group,YBJZD low-,medium-,and high-dose groups,and the positive group.The 24-h urine samples were collected.Biochemical indicators were monitored,and kidney tissues were collected for pathological analysis using light microscopy.The results showed that through 4 weeks of drug intervention,the urinary protein level was lower in the YBJZD and positive groups compared with the model group(P<0.05).Serum levels of BUN,SCr,and TG were significantly lower(P<0.01),and ALB was significantly higher(P<0.01)in the YBJZD and positive groups compared with the model group.Compared with the model group,the pathological injury of kidney tissue in the YBJZD and positive groups was significantly alleviated.These outcomes proved that YBJZD had a renal protective effect on AN rats.展开更多
基金supported by Applied basic Research Project of Science and Technology Department of Shanxi Province(Grant No.201901D-111343)the Open Project of Key Laboratory of Shanxi Province(Grant No.SXIDL-2018-09)Shanxi University of Traditional Chinese Medicine Science and Technology Innovation Ability Training program“basic Research special project”(Grant No.2020PY-JC-20).
文摘In the present study,we aimed to investigate the protective effect of Yuebi Jiazhu Decoction(YBJZD)on the kidney of adriamycin nephropathy(AN)rats.Rats were injected with adriamycin for modeling,except for the control group.After the successful establishment of the animal model,rats were randomly divided into the model group,YBJZD low-,medium-,and high-dose groups,and the positive group.The 24-h urine samples were collected.Biochemical indicators were monitored,and kidney tissues were collected for pathological analysis using light microscopy.The results showed that through 4 weeks of drug intervention,the urinary protein level was lower in the YBJZD and positive groups compared with the model group(P<0.05).Serum levels of BUN,SCr,and TG were significantly lower(P<0.01),and ALB was significantly higher(P<0.01)in the YBJZD and positive groups compared with the model group.Compared with the model group,the pathological injury of kidney tissue in the YBJZD and positive groups was significantly alleviated.These outcomes proved that YBJZD had a renal protective effect on AN rats.
