Recently, we have analyzed expressional transcriptome and proteome for a number of cancer cell lines, including 8 hepatocellular carcinoma （HCC） ones [1,2]. These 8 HCC cell lines consist of 6 metastatic （all with ...Recently, we have analyzed expressional transcriptome and proteome for a number of cancer cell lines, including 8 hepatocellular carcinoma （HCC） ones [1,2]. These 8 HCC cell lines consist of 6 metastatic （all with mutant p53） and 2 non-metastatic （with a mutant and a lost p53） ones, being all HBV traceable for relatively close genetic-backgrounds. We have analyzed the related dataset and obtained transcrip- tome （16353 genes） and proteome （7861 proteins） of these 8 HCC cell lines, and explored a group of up-regulated and down-regulated genes [3].展开更多
Dear Editor,Recent studies indicate that cellular metabolism plays a key role in supporting immune cell development,maintenance and function(Norata et al.,2015).For example,sensing of microbial ligands by macrophages ...Dear Editor,Recent studies indicate that cellular metabolism plays a key role in supporting immune cell development,maintenance and function(Norata et al.,2015).For example,sensing of microbial ligands by macrophages triggers increased glucose metabolism,which delivers energy to support antimicrobial inflammation and the production of cytokines.This effect further enhances the generation of mitochondrial reactive oxygen species(ROS)to fight infections.展开更多
基金the International S&T Cooperation Program of China (2014DFB30020)the National Basic Research Program of China (2013CB910502, 2011CB910600)+1 种基金the National High Technology Research and Development Program of China(2012AA020200)the National Science and Technology Major Project (2012ZX1002012)
文摘Recently, we have analyzed expressional transcriptome and proteome for a number of cancer cell lines, including 8 hepatocellular carcinoma （HCC） ones [1,2]. These 8 HCC cell lines consist of 6 metastatic （all with mutant p53） and 2 non-metastatic （with a mutant and a lost p53） ones, being all HBV traceable for relatively close genetic-backgrounds. We have analyzed the related dataset and obtained transcrip- tome （16353 genes） and proteome （7861 proteins） of these 8 HCC cell lines, and explored a group of up-regulated and down-regulated genes [3].
基金This research was financilly suppoted by National Natural Science Foundation of China grants(81672746)National Key Research and Development Program(2018YFA0800302)National Natural Science Foundation of China grants(81872258 and 81472566).
文摘Dear Editor,Recent studies indicate that cellular metabolism plays a key role in supporting immune cell development,maintenance and function(Norata et al.,2015).For example,sensing of microbial ligands by macrophages triggers increased glucose metabolism,which delivers energy to support antimicrobial inflammation and the production of cytokines.This effect further enhances the generation of mitochondrial reactive oxygen species(ROS)to fight infections.
