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基于三维重建的影像学分析在部分实性肺结节中的研究进展 被引量:8
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作者 刘子成 杨赫 +2 位作者 王鸿亚 陈亮 朱全 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第2期124-129,共6页
中国肺癌的发病率和死亡率居所有恶性肿瘤之首,随着高分辨率计算机断层扫描(computed tomography, CT)在临床的普及,胸部CT已成为临床筛查早期肺癌、降低肺癌死亡率的重要手段。早期肺腺癌的影像学常表现为含有磨玻璃成分的部分实性结... 中国肺癌的发病率和死亡率居所有恶性肿瘤之首,随着高分辨率计算机断层扫描(computed tomography, CT)在临床的普及,胸部CT已成为临床筛查早期肺癌、降低肺癌死亡率的重要手段。早期肺腺癌的影像学常表现为含有磨玻璃成分的部分实性结节。随着影像学的发展,部分实性结节的影像学表现与其预后的关系越来越受关注。同时随着三维重建技术的发展,提高了临床医师对该类结节诊断治疗的精确性。本文聚焦于部分实性结节的传统影像学分析和基于三维重建的影像学分析,对两者的利弊作一系统阐述。 展开更多
关键词 肺肿瘤 三维重建 实性成分 预后
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浸润性肺腺癌EGFR、ALK基因突变状态与影像学、病理学特征的相关性 被引量:12
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作者 杨赫 刘子成 +5 位作者 王鸿亚 陈亮 王俊 闻伟 徐心峰 朱全 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第3期147-155,共9页
背景与目的 当前针对肺腺癌表皮生长因子受体(epidermal growth factor receptor,EGFR)与间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)基因突变位点的靶向治疗研究进展十分迅速,为晚期肺腺癌患者的治疗带来新的希望,然而目前EGFR... 背景与目的 当前针对肺腺癌表皮生长因子受体(epidermal growth factor receptor,EGFR)与间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)基因突变位点的靶向治疗研究进展十分迅速,为晚期肺腺癌患者的治疗带来新的希望,然而目前EGFR、ALK基因突变在腺癌患者中所具有的特异性影像学与病理学特征仍存在较多争议,本研究进一步探索浸润性肺腺癌EGFR、ALK基因突变与影像学、病理学特征的相关性。方法 纳入2018年1月-2019年12月在我们中心接受手术的525例肺腺癌患者。根据术后基因检测的结果 将患者分为EGFR基因、ALK基因突变组与野生组,并将EGFR基因突变组分层为外显子19、外显子21突变亚型,将突变组与野生组的病理学特征如组织学亚型、淋巴结转移、脏层胸膜侵犯(visceral pleuralinvision,VPI)等,影像学特征如肿瘤最大直径、实性成分占比(consolidation tumor ratio,CTR)、分叶征、毛刺征、胸膜牵拉征、空气支气管征、空泡征等进行单因素分析及多因素逻辑回归分析,探讨基因突变组是否具有特异性表现。结果 EGFR基因突变组常见于女性(OR=2.041,P=0.001),存在更多胸膜牵拉征征象(OR=1.506,P=0.042),病理学上与淋巴结转移及VPI相关性较小(P>0.05)。其中外显子21突变型腺癌多见于年龄相对较大者(OR=l.022,P=0.036)及女性(OR=2.010,P=0.007),常伴有较大肿瘤直径(OR=l.360,P=0.039)及胸膜牵拉征(OR=1.754,P=0.029)。外显子19突变型腺癌常见于女性(OR=2.230,P=0.009)、肿瘤实性成分比例较高(OR=1.589,P=0.047)、存在更多分叶征(OR=2.762,P=0.026)。ALK基因突变易发生于有吸烟史(OR=2.950,P=0.045)及较年轻患者(OR=1.070,P=0.002),病理学上存在更多微乳头型成分(OR=4.184,P=0.019)及VPI (OR=2.986,P=0.034)。结论 EGFR、ALK基因突变型腺癌具有特异的影像学及临床病理学特征,且EGFR外显子19或21突变具有不同的影像学特征,对制定肺结节临床处理策略具有重要意义。 展开更多
关键词 肺肿瘤 表皮生长因子受体 间变性淋巴瘤激酶 病理特征 放射学
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胸部CT二维与三维特征对肺磨玻璃结节浸润性的诊断效能对比 被引量:4
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作者 王鸿亚 杨赫 +3 位作者 刘子成 陈亮 徐心峰 朱全 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第10期723-729,共7页
背景与目的目前越来越多的研究通过肺结节三维特征预测浸润性腺癌(invasive adenocarcinoma,IAC),但少有研究证实与传统的肺结节二维特征相比,三维特征诊断IAC更有优势。本文分别从三维与二维层面分析IAC与非浸润性腺癌组胸部计算机断... 背景与目的目前越来越多的研究通过肺结节三维特征预测浸润性腺癌(invasive adenocarcinoma,IAC),但少有研究证实与传统的肺结节二维特征相比,三维特征诊断IAC更有优势。本文分别从三维与二维层面分析IAC与非浸润性腺癌组胸部计算机断层扫描(computed tomography,CT)特征差异,比较二者鉴别IAC的优劣,其中非浸润性腺癌组包括前驱性腺体病变(precursor glandular lesions,PGL)及微浸润性腺癌(minimally invasive adenocarcinoma,MIA)。方法收集2019年1月-2019年12月1,045例肺磨玻璃结节(ground-glass opacity,GGO)手术患者临床资料,回顾性分析术前CT影像特征与病理学结果的相关性,由多因素Logistic回归分别按二维与三维分类筛选出鉴别IAC的独立影响因素,通过受试者工作特征(receiver operating characteristic,ROC)曲线找出鉴别IAC的cut-off值,并以约登指数评估诊断IAC的能力。结果二维因素中结节最大径、实性成分最大径、纵隔窗结节最大径以及三维因素中结节总体积、实性部分体积、平均CT值均是诊断IAC的独立危险因素。将各项指标通过约登指数排列:实性部分体积(0.601)>结节体积(0.536)>实性成分最大径(0.525)>结节最大径(0.518)>纵隔窗结节最大径(0.488)>实性成分体积占比(0.471)>肿瘤消失率(tumor disappearance ratio,TDR)(0.468)>实性成分占比(consolidation/tumor ratio,CTR)(0.394)>平均CT值(0.380)。结论三维层面CT特征诊断IAC优于二维层面,实性成分大小优于结节总体大小。 展开更多
关键词 肺肿瘤 放射学 计算机断层扫描 计算机三维成像 体积
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“静脉血栓栓塞症”单中心真实世界临床诊疗实践分析研究 被引量:1
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作者 陈兵 朱永斌 +4 位作者 何源 潘以锋 王洪亚 李苹 朱世钧 《中华血管外科杂志》 2023年第2期178-182,共5页
静脉血栓栓塞症(VTE)是临床发病率较高的疾病和合并症, 是造成低风险死亡事件和医疗纠纷的重要因素。近年来, 在国家卫生健康委员会和有关部门推动下, 建立了积极的VTE风险评估、预防策略和指南, 取得了非常好的成绩。然而仍然缺乏大规... 静脉血栓栓塞症(VTE)是临床发病率较高的疾病和合并症, 是造成低风险死亡事件和医疗纠纷的重要因素。近年来, 在国家卫生健康委员会和有关部门推动下, 建立了积极的VTE风险评估、预防策略和指南, 取得了非常好的成绩。然而仍然缺乏大规模VTE发病率调查数据, 而不同层级医院、科室对于VTE的整体评估、预防、治疗差异较大。本文就单中心两年的官方数据进行收集整理, 对VTE的发病率和真实世界抗凝药物应用进行分析总结, 为本领域进一步发展提供基础数据。 展开更多
关键词 静脉血栓栓塞症 肺动脉栓塞 静脉血栓栓塞症风险评估 抗凝治疗
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Finding the superior mode basis for mode-division multiplexing:a comparison of spatial modes in air-core fiber
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作者 hongya wang Jianzhou Ai +2 位作者 Zelin Ma Siddharth Ramachandran Jian wang 《Advanced Photonics》 SCIE EI CAS CSCD 2023年第5期50-67,共18页
Diverse spatial mode bases can be exploited in mode-division multiplexing(MDM)to sustain the capacity growth in fiber-optic communications,such as linearly polarized(LP)modes,vector modes,LP orbital angular momentum(L... Diverse spatial mode bases can be exploited in mode-division multiplexing(MDM)to sustain the capacity growth in fiber-optic communications,such as linearly polarized(LP)modes,vector modes,LP orbital angular momentum(LP-OAM)modes,and circularly polarized OAM(CP-OAM)modes.Nevertheless,which kind of mode bases is more appropriate to be utilized in fiber still remains unclear.Here,we aim to find the superior mode basis in MDM fiber-optic communications via a system-level comparison in air-core fiber(ACF).We first investigate the walk-off effect of four spatial mode bases over 1-km ACF,where LP and LP-OAM modes show intrinsic mode walk-off,while it is negligible for vector and CP-OAM modes.We then study the mode coupling effect of degenerate vector and CP-OAM modes over 1-km ACF under fiber perturbations,where degenerate even and odd vector modes suffer severe mode cross talk,while negligible for highorder degenerate CP-OAM modes based on the laws of angular momentum conservation.Moreover,we comprehensively evaluate the system-level performance for data-carrying single-channel and two-channel MDM transmission with different spatial mode bases under various kinds of fiber perturbations(bending,twisting,pressing,winding,and out-of-plane moving).The obtained results indicate that the CP-OAM mode basis shows superiority compared to other mode bases in MDM fiber-optic communications without using multiple-input multiple-output digital signal processing.Our findings may pave the way for robust shortreach MDM optical interconnects for data centers and high-performance computing. 展开更多
关键词 fiber-optic communications mode-division multiplexing spatial modes linearly polarized modes vector modes linearly polarized orbital angular momentum modes circularly polarized orbital angular momentum modes air-core fiber fiber perturbations
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Rock crevices determine woody and herbaceous plant cover in the karst critical zone 被引量:4
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作者 hongyan LIU Zihan JIANG +6 位作者 Jingyu DAI Xiuchen WU Jian PENG hongya wang Jeroen MEERSMANS Sophie M.GREEN Timothy A.QUINE 《Science China Earth Sciences》 SCIE EI CAS CSCD 2019年第11期1756-1763,共8页
The study of the critical zones(CZs) of the Earth link the composition and function of aboveground vegetation with the characteristics of the rock layers, providing a new way to study how the unique rock and soil cond... The study of the critical zones(CZs) of the Earth link the composition and function of aboveground vegetation with the characteristics of the rock layers, providing a new way to study how the unique rock and soil conditions in karst regions affect the aboveground vegetation. Based on survey results of the rocks, soils and vegetation in the dolomite and limestone distribution areas in the karst area of central Guizhou, it was found that woody plant cover increases linearly with the number of cracks with a width of more than 1 mm, while the cover of herbaceous plants shows the opposite trend(p<0.01). The dolomite distribution area is characterized by undeveloped crevices, and the thickness of the soil layer is generally less than 20 cm, which is suitable for the distribution of herbaceous plants with shallow roots. Due to the development of crevices in the limestone distribution area, the soil is deeply distributed through the crevices for the deep roots of trees, which leads to a diversified species composition and a complicated structure in the aboveground vegetation. Based on moderate resolution imaging spectroradiometer(MODIS) remote sensing data from 2001 to 2010, the normalized differentiated vegetation index(NDVI) and annual net primary productivity(NPP) results for each phase of a 16-day interval further indicate that the NDVI of the limestone distribution area is significantly higher than that in the dolomite distribution area, but the average annual NPP is the opposite. The results of this paper indicate that in karst CZs, the lithology determines the structure and distribution of the soil, which further determines the cover of woody and herbaceous plants in the aboveground vegetation. Although the amount of soil in the limestone area may be less than that in the dolomite area, the developed crevice structure is more suitable for the growth of trees with deep roots, and the vegetation activity is strong. At present, the treatment of rocky desertification in karst regions needs to fully consider the rock-soilvegetation-air interactions in karst CZs and propose vegetation restoration measures suitable for different lithologies. 展开更多
关键词 VEGETATION composition VEGETATION productivity DOLOMITE LIMESTONE KARST critical zone
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Amplifying Orbital Angular Momentum Modes in Ring-Core Erbium-Doped Fiber 被引量:1
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作者 Jun Liu Shi Chen +6 位作者 hongya wang Shuang Zheng Long Zhu Andong wang Lulu wang Cheng Du Jian wang 《Research》 EI CAS 2020年第1期1342-1353,共12页
Lots of research efforts have been devoted to increase the transmission capacity in optical communications using orbital angular momentum(OAM)multiplexing.To enable long-haul OAM mode transmission,an in-line OAM fiber... Lots of research efforts have been devoted to increase the transmission capacity in optical communications using orbital angular momentum(OAM)multiplexing.To enable long-haul OAM mode transmission,an in-line OAM fiber amplifier is desired.A ring-core fiber(RCF)is considered to be a preferable design for stable OAM mode propagation in the fiber.Here,we demonstrate an OAM fiber amplifier based on a fabricated ring-core erbium-doped fiber(RC-EDF).We characterize the performance of the RC-EDF-assisted OAM fiber amplifier and demonstrate its use in OAM multiplexing communications with OAM modes carrying quadrature phase-shift keying(QPSK)and quadrature amplitude modulation(QAM)signals.The amplification of two OAM modes over four wavelengths is demonstrated in a data-carrying OAM-division multiplexing and wavelength-division multiplexing system.The obtained results show favorable performance of the RC-EDF-assisted OAM fiber amplifier.These demonstrations may open up new perspectives for long-haul transmission in capacity scaling fiber-optic communications employing OAM modes. 展开更多
关键词 AMPLIFIER FIBER ERBIUM
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Indication of paleoecological evidence on the evolution of alpine vegetation productivity and soil erosion in central China since the mid-Holocene
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作者 Ying CHENG hongyan LIU +5 位作者 hongya wang Deliang CHEN Philippe CIAIS Yao LUO Xiuchen WU &Yi YIN 《Science China Earth Sciences》 SCIE EI CSCD 2021年第10期1774-1783,共10页
Although alpine ecosystems have been commonly recognized as sensitive to recent climate change,few studies have examined its impact on the long-term productivity of vegetation and soil erosion.Using paleoecological re... Although alpine ecosystems have been commonly recognized as sensitive to recent climate change,few studies have examined its impact on the long-term productivity of vegetation and soil erosion.Using paleoecological records,these two aspects were examined in the alpine zone of the Taibai Mountains(elevation,3767 m)in monsoon-dominated East Asia since the middle Holocene.Proxies for the productivity of vegetation and severity of soil erosion from high-resolution alpine lacustrine records show that the productivity and soil erosion were closely related to mean annual temperature and summer precipitation from the East Asian Summer Monsoon(EASM),respectively.Specifically,when the mean annual temperature was low and precipitation was abundant,during 5800–4000 calendar years before the present(cal.yr BP),the alpine ecosystem was characterized by low vegetation productivity and severe soil erosion.However,the productivity increased and soil erosion decreased from 4000 cal.yr BP onwards.These results highlight the role of paleoecological evidence in studying ecosystem services on longer time scales,which is significant in making policies for sustainable development under climate change in regions for which such long-term monitoring data are not available. 展开更多
关键词 POLLEN Vegetation dynamics Alpine lake sediments Erosion intensity Paleoecological indicators
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