Dear Editor,Systemic lupus erythematosus(SLE),one of the most common autoimmune diseases in reproductive females,is a multifactorial disease involving genetic,environmental,and hormonal factors.1 It occurs at a 9:1 fe...Dear Editor,Systemic lupus erythematosus(SLE),one of the most common autoimmune diseases in reproductive females,is a multifactorial disease involving genetic,environmental,and hormonal factors.1 It occurs at a 9:1 female-to-male ratio,and the sex predisposition suggests that the estrogen system plays an essential role in the developing of SLE.The effects of estrogen have traditionally been attributed to the classical nuclear estrogen receptors(ERs),ERα,and ERβ,which predominantly regulate transcription.Guanine nucleotide-binding protein-coupled estrogen receptor 1(GPER1)is a transmembrane receptor for estrogen that mediates several rapid cellular effects of estrogen.2 Large amounts of autoantibodies characterize SLE,and anti-estrogen receptor autoantibodies are likely to affect the function of immune cells in SLE but are not yet fully understood.展开更多
Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases,which involve plenty of immune cells,pathogens and autoantibodies.Nanomedicine has a gr...Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases,which involve plenty of immune cells,pathogens and autoantibodies.Nanomedicine has a great potential in modulating immune system.Particularly,biomimetic nanomodulators can be designed for prevention,diagnosis and therapy to achieve a better targeted immunotherapy.With the development of materials science and bioengineering,a wide range of membranecoated nanomodulators are available.Herein,we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious diseases.We also rethink the challenges or limitations in the progress of the therapeutic nanoplatform,and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.展开更多
基金the Natural Science Foundation of China(82101841,X.Z.,81601384,H.Q.,81971536,82171779,G.S.,and 81971496,Y.L.)the Natural Science Foundation of Fujian Province(2020J05301,X.Z.,2021J05292,H.Q.)the Scientific and Technological Projects of Xiamen City(3502Z20209004,G.S.and 3502Z20214ZD3001,X.Z.)。
文摘Dear Editor,Systemic lupus erythematosus(SLE),one of the most common autoimmune diseases in reproductive females,is a multifactorial disease involving genetic,environmental,and hormonal factors.1 It occurs at a 9:1 female-to-male ratio,and the sex predisposition suggests that the estrogen system plays an essential role in the developing of SLE.The effects of estrogen have traditionally been attributed to the classical nuclear estrogen receptors(ERs),ERα,and ERβ,which predominantly regulate transcription.Guanine nucleotide-binding protein-coupled estrogen receptor 1(GPER1)is a transmembrane receptor for estrogen that mediates several rapid cellular effects of estrogen.2 Large amounts of autoantibodies characterize SLE,and anti-estrogen receptor autoantibodies are likely to affect the function of immune cells in SLE but are not yet fully understood.
基金supported by the Major State Basic Research Development Program of China(2017YFA0205201)the National Natural Science Foundation of China(81925019,81901876,81801817,81603015 and U1705281)+3 种基金the Fundamental Research Funds for the Central Universities(20720190138,20720190088 and 20720200019,China)Medical and Health Key project of Xiamen(3502Z20191106 and 2020Y4003,China)the Program for New Century Excellent Talents in University,China(NCET13-0502)China Postdoctoral Science Foundation Funded Project(K6419001,China)。
文摘Autoimmune or infectious diseases often instigate the undesirable damages to tissues or organs to trigger immune-related diseases,which involve plenty of immune cells,pathogens and autoantibodies.Nanomedicine has a great potential in modulating immune system.Particularly,biomimetic nanomodulators can be designed for prevention,diagnosis and therapy to achieve a better targeted immunotherapy.With the development of materials science and bioengineering,a wide range of membranecoated nanomodulators are available.Herein,we summarize recent advancements of bioinspired membrane-coated nanoplatform for systemic protection against immune-related diseases including autoimmune and infectious diseases.We also rethink the challenges or limitations in the progress of the therapeutic nanoplatform,and discuss the further application of the nanomodulators in the view of translational medicine for combating immune-related diseases.
