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Platinum-based chemotherapy for metastatic insulinoma harboring germline mutation in DNA damage repair pathway:a case report
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作者 Kaili Yang hongyan ying +3 位作者 Mei Guan Lina Wang Jia Xu Yuejuan Cheng 《Journal of Pancreatology》 2024年第2期167-169,共3页
Malignant insulinomas are rare neuroendocrine tumors that require management for both symptomatic control and tumor reduction.It is clinically challenging to optimize treatment strategies for refractory malignant insu... Malignant insulinomas are rare neuroendocrine tumors that require management for both symptomatic control and tumor reduction.It is clinically challenging to optimize treatment strategies for refractory malignant insulinoma.We report a case of metastatic grade 3 insulinoma presented with recurrent hypoglycemia in a 23-year-old female with RAD51D p.Q192 germline mutation.During the disease course of 5 years,the tumor has continuously progressed despite locoregional therapy and multiple lines of systemic treatment.However,oxaliplatin-based chemotherapy achieved a partial response,which was maintained for 2 years.The hypoglycemic symptoms were controlled after the treatment response and did not recur.The platinum-based regimen could be a feasible therapeutic strategy for malignant insulinoma.The relationship between germline mutation in the DNA damage repair pathway and treatment response to platinum-based regimens in neuroendocrine tumors warrants further investigation. 展开更多
关键词 CHEMOTHERAPY DNA damage repair Germline mutation Malignant insulinoma
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