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Macrocyclic peptides as regulators of protein-protein interactions 被引量:1
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作者 Yang Jiang hongyi long +1 位作者 Yujie Zhu Yi Zeng 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第7期1067-1073,共7页
Protein-protein interactions(PPIs) are recognized as attractive therapeutic targets. However targeting PPIs especially intracellular ones has been proven extremely difficult for conventional drug-like small molecules,... Protein-protein interactions(PPIs) are recognized as attractive therapeutic targets. However targeting PPIs especially intracellular ones has been proven extremely difficult for conventional drug-like small molecules, and biological drugs such as monoclonal antibodies have difficulty in reaching intracellular targets. Macrocyclic peptides are promising candidates of PPI regulators for their potential in combining high potency and biological stability together. Cell permeability of macrocyclic peptides may also be achieved by structural modifications or conjugation to a cell-penetrating sequence. Significant progress has been made in this research area in recent years. Important technology progress and recent examples of macrocyclic peptide PPI modulators are reviewed. 展开更多
关键词 MACROCYCLE Macrocyclic peptide Protein-protein interaction INHIBITOR Cell-penetrating peptide
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