Effects of Wuwei Xiaodu Decoction on Uterine Energy Metabolism and Serum Inflammatory Factors in Rats with Acute Pelvic Inflammatory Disease

[Objectives]To observe the effects of Wuwei Xiaodu Decoction on uterine energy metabolism and serum inflammatory factors in the acute pelvic inflammatory disease(APID)model.[Methods]75 Wistar rats(females)were randomly divided into control group,model group and Wuwei Xiaodu Decoction low,medium and high dose groups(n=15).Except for the control group,the rat APID model was established by right uterine inoculation.On the fifth day after inoculation,the low,medium and high dose groups of Wuwei Xiaodu Decoction were administered at 4,8 and 16 g/kg,and the control group and model group received normal saline.Rats were killed 12 h after nondose administration,blood was collected from the abdominal aorta and measured by ELISA for serum interleukin-6(interleukin-6,IL-6),IL-8,and C-reactive proteins(CRP);the right uterus of rats was tested for high-energy phosphate adenosine phosphate(AMP),adenosine diphosphate(ADP),adenosine triphosphate(ATP)and total adenine nucleotides(TAN)level to evaluate the uterine energy metabolism.[Results]AMP,ADP,ATP and TAN were significantly higher in the Wuwei Xiaodu Decoction of low,medium and high dose than the model group,while the serum IL-6,IL-8 and CRP were significantly lower than the model group,and the difference between the low,medium and high doses(P<0.05).[Conclusions]The Wuwei Xiaodu Decoction can dose-dependent promote uterine energy metabolism and inhibit inflammatory response in APID model rats.

Effect of Salvia Miltiorrhiza Injection on Blood Pressure and Cardiac Function in Rats with Gestational Hypertension and Preeclampsia

Objective: This study is to observe the effects of Salvia miltiorrhiza injection on blood pressure and cardiac function in rats with pregnancy-induced hypertension and preeclampsia. Methodology: Syncytiotrophoblast microvilli (stbm) and l-arginine nitrosyl methyl ester were screened out via caudal vein injection. Twenty gestational hypertension-preeclampsia model SD (Sprague Dawley) rats successfully induced by L-NAME (L-arginine Nitrosyl methyl ester) were randomly divided into 2 groups (model group and Danshen injection group, n = 10). Then another 10 normal pregnant SD rats without model were selected as blank control group. The Salvia miltiorrhiza injection group was given Salvia miltiorrhiza injection (0.5 g?kg?1?d?1) through tail vein, and the control group and model group were given equal volume of normal saline through tail vein injection. All three groups were treated by tail vein injection once a day (d) for 7 days. After treatment, heart rate (HR), Systolic pressure (SP), diastolic pressure (DP) and mean arterial pressure (MAP) were measured by tail artery. Left ventricular end-diastolic diameter (LVDd) and Left ventricular end systolic diameter (LVDs) were recorded by echocardiography. Left ventricular end diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP), left ventricular ejection fraction (left ventricular ejection) fraction, LVEF) and the maximum rate of increase/decrease of left ventricular pressure during isovolemic systole (+dp/dtmax/?dp/dtmax);Endothelin-1 (ET-1) levels in rat tail vein blood were detected by ELISA. Results: SP, DP, MP, HR, LVSP, LVDs and ?dp/dtmaxx were all decreased, plasma ET-1 expression was low, and LVDd, LVEDP, LVEF, and +dp/dtmax were all increased in the Salvia miltiorroot injection group, with statistical significance compared to the model group (p Conclusion: Salvia miltiorrhiza injection can improve the cardiac function and reduce blood pressure in rats with pregnancy-induced hypertension and preeclampsia, and the mechanism may be related to alleviating systemic arteriolar spasm by regulating ET-1 level.

Hydrothermal Self-assembly Synthesis of Mn3O4Reduced Graphene Oxide Hydrogel and Its High Electrochemical Performance for Supercapacitors

In the present work Mn3O4/reduced graphene oxide hydrogel （Mn3O4-rGOH） with three dimensional （3D） networks was fabricated by a hydrothermal self-assembly route. The morphology, composition, and microstructure of the as-obtained samples were characterized using powder X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, thermogravimetry analysis （TG）, atomic absorption spectrometry （AAS）, field emission scanning electron microscopy （FESEM） and transmission electron microscope （TEM）. Moreover, the electrochemical behaviors were evaluated by cyclic voltammogram （CV）, galvanostatic charge-discharge and electrochemical impedance spectroscopy （EIS）. The test results indicated that the hydrogel with 6.9% Mn3O4 achieved specific capacitance of 148 F.g^-1 at a specific current of 1 A.g^-1, and showed excellent cycling stabilily with no decay after 1200 cycles. In addition, its specific capacitance could retain 70% even at 20 A.g^- 1 in comparison with that at 1 A.g ^-1 and the operating window was up to 1.8 V in a neutral electrolyte.

Ruthenium Oxide/Reduced Graphene Oxide Nanoribbon Composite and Its Excellent Rate Capability in Supercapacitor Application

Chemical oxidation is used to cut and unzip multi-walled carbon nanotubes in the transverse direction and the axial direction to form graphene oxide nanoribbon （GONR）. Ruthenium oxide/reduced graphene oxide nanoribbon composite （RuO2/rGONR） with a 72.5 wt% RuO2 loading is synthesized through an aqueous-phase reaction, in which GONR is served as starting material, followed by mild thermal treatment in ambient air. The resulting RuO2/rGONR composite achieves specific capacitance up to 677 F.g l at the current density of 1 A·g^-1 in three-electrode system using 1 mol·L^-1 H2SO4 as electrolyte. The resultant electrode exhibits an excellent rate capability （91.8% retention rate at 20 A·g^-1）. Especially, the symmetric supercapacitor assembled on the basis of RuO2/rGONR electrode delivers high energy density （16.2 Wh·kg^-1） even at the power density of 9885 W·kg^-1, which is very essential for supercapacitors.

Non-Covalent Functionalization of Graphene with Bisphenol A for High-Performance Supercapacitors

The reduced graphene oxide(RGO)/bisphenol A(BPA)composites were prepared by an adsorption-reduction method.The composites are characterized by X-ray diffraction(XRD),UV-vis,thermogravimetric(TG)analysis,field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM).The results confirm that BPA is adsorbed on the basal plane of RGO byπ-πstacking interaction.Furthermore,the electrochemical behaviors were evaluated by cyclic voltammetry,galvanostatic charge/discharge techniques and electrochemical impedance spectroscopy(EIS).The results show that the RGO/BPA nanocomposites exhibit ultrahigh specific capacitance of 466 F•g^(−1) at a current density of 1 A•g^(−1),excellent rate capability(more than 81%retention at 10 A•g^(−1) relative to 1 A•g^(−1))and superior cycling stability(90%capacitance decay after 4000 cycles).Consequently,the RGO/BPA nanocomposites can be regarded as promising electrode materials for supercapacitor applications.

Catalytic PtPd bimetal nanocrystals with high-index facets for radiation injury repair

Radiotherapy is one of the most important clinical cancer treatments,which works mainly by delive ring a prescribed radiation dose to the tumor tissues.However,high doses of radiation may also lead many irreversible damages to the surrounding normal tissues.Thereby,how to effectively reduce these sideeffects has been a significant factor in influencing cancer therapeutic effect.In this work,we synthesized the hollow PtPd nanocubes with high-index facets,and investigated the radiation protection capability in vitro and in vivo.Our results showed the PtPd nanocrystals can decrease the ROS level and improve the survival rate of radiated cells.Meanwhile,survival rate of radiated mice can significantly increase from 0 to 30%after PtPd treatment.Consequently,the enzyme and ROS level in radiated mice can be recovered.