In addition to its role in sensing intraluminalmicrobial antigens,soluble (s)CD14 may regulate immune responses by its lesser known function as a lipid carrier with possible influences in the production of fatty acid-...In addition to its role in sensing intraluminalmicrobial antigens,soluble (s)CD14 may regulate immune responses by its lesser known function as a lipid carrier with possible influences in the production of fatty acid-derived eicosanoids. We investigated the interrelations of fatty acids,prostaglandin E2 (PGE2),and sCD14 and their role in infant atopic eczema during the firstyear of life. Serum and breast milk samples from mothers andserum samples from their infants were collected at infant’s age 3 mo and analyzed for sCD14 and PGE2 concentrations and for fatty acid compositions. The main correlation of sCD14 was with arachidonic acid (20:4n-6) (AA). Dihomo-γ-linolenicacid (20:3n-6) (DHGLA) and the ratio of n-6 to n-3 fatty acids correlated positively and docosahexaenoic acid (22:6n-3) (DHA) and sum of n-3 fatty acid negatively with PGE2 inmother’s serum and linoleic acid (LA) negatively with PGE2 inbreast milk. Soluble CD14 tended to be higher and LA,tota lpolyunsaturated fatty acid (PUFA),and sum of n-6 fatty acids were lower in breastmilk received by infants with atopic eczemacompared with those without. These results suggest that fattyacids contribute to the regulation of innate and adaptive immuneresponses and link intraluminal exposures,mother’s diet,andmicrobes.展开更多
文摘In addition to its role in sensing intraluminalmicrobial antigens,soluble (s)CD14 may regulate immune responses by its lesser known function as a lipid carrier with possible influences in the production of fatty acid-derived eicosanoids. We investigated the interrelations of fatty acids,prostaglandin E2 (PGE2),and sCD14 and their role in infant atopic eczema during the firstyear of life. Serum and breast milk samples from mothers andserum samples from their infants were collected at infant’s age 3 mo and analyzed for sCD14 and PGE2 concentrations and for fatty acid compositions. The main correlation of sCD14 was with arachidonic acid (20:4n-6) (AA). Dihomo-γ-linolenicacid (20:3n-6) (DHGLA) and the ratio of n-6 to n-3 fatty acids correlated positively and docosahexaenoic acid (22:6n-3) (DHA) and sum of n-3 fatty acid negatively with PGE2 inmother’s serum and linoleic acid (LA) negatively with PGE2 inbreast milk. Soluble CD14 tended to be higher and LA,tota lpolyunsaturated fatty acid (PUFA),and sum of n-6 fatty acids were lower in breastmilk received by infants with atopic eczemacompared with those without. These results suggest that fattyacids contribute to the regulation of innate and adaptive immuneresponses and link intraluminal exposures,mother’s diet,andmicrobes.
