Objective:To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen(HBeAg). Study design:In the prospective c...Objective:To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen(HBeAg). Study design:In the prospective cohort study,81 HBeAg-positive children with chronic hepatitis B virus(HBV) infection from 40 unrelated families were recruited and followed-up regularly for a mean period of 17.70 ±3.23years. The association between HLA antigen and the age at HBeAg seroconversion was analyzed using Cox regression model with shared frailties under left truncation and right censorship. Results:HLA-B61 and HLA-DQB1*0503 antigen spredicted a higher HBeAg seroconversion rate (relative incidence = 6.17 and 3.22,P = 0.024 and 0.017,respectively).Within-family frailty in our sibling cohort study demonstrated a negligible or a low degree of within-family correlation with spontaneous HBeAg seroconversion in each HLA antigen. Conclusions:HLA class I antigen B61 and class II antigen DQB1*0503 are associated with earlier HBeAg seroconversion in Taiwan Residents children with chronic HBV infection.展开更多
文摘Objective:To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen(HBeAg). Study design:In the prospective cohort study,81 HBeAg-positive children with chronic hepatitis B virus(HBV) infection from 40 unrelated families were recruited and followed-up regularly for a mean period of 17.70 ±3.23years. The association between HLA antigen and the age at HBeAg seroconversion was analyzed using Cox regression model with shared frailties under left truncation and right censorship. Results:HLA-B61 and HLA-DQB1*0503 antigen spredicted a higher HBeAg seroconversion rate (relative incidence = 6.17 and 3.22,P = 0.024 and 0.017,respectively).Within-family frailty in our sibling cohort study demonstrated a negligible or a low degree of within-family correlation with spontaneous HBeAg seroconversion in each HLA antigen. Conclusions:HLA class I antigen B61 and class II antigen DQB1*0503 are associated with earlier HBeAg seroconversion in Taiwan Residents children with chronic HBV infection.
