Diabetic nephropathy is one of the most common causes of end-stage renal disease worldwide and is associated with increased mortality in patients with type 1 and type 2 diabetes.Autophagy is a highly conserved"au...Diabetic nephropathy is one of the most common causes of end-stage renal disease worldwide and is associated with increased mortality in patients with type 1 and type 2 diabetes.Autophagy is a highly conserved"autophagy"pathway and is an important mechanism for maintaining glomerular and tubular homeostasis.Emerging evidence suggests that targeted autophagy pathway activation and restoration of autophagy activity may have renal protection.Glomerular endothelial cells are an important key factor in the development of diabetic nephropathy.Endothelial dysfunction is involved in the development of diabetic and non-diabetic glomerular injury and renal fibrosis.Evidence of glomerular endothelial dysfunction in the late stages of diabetic nephropathy,such as thrombotic microangiopathy,including impairment of glomerular capillary microaneurysms and glomerular membrane lysis autophagy,is related to the pathogenesis of diabetic nephropathy.Here,we mainly introduced the research progress of the effects of glomerular endothelial cell autophagy on diabetic nephropathy.展开更多
Teachers’language modeling behaviors,including frequent conversation,open-ended questions,repetition and extension,self-and parallel talks,and advanced language,have significantly impacted young children’s language ...Teachers’language modeling behaviors,including frequent conversation,open-ended questions,repetition and extension,self-and parallel talks,and advanced language,have significantly impacted young children’s language learning and development.This study examined 60 classrooms from 20 kindergartens in Guangzhou,China,and analyzed 62 films of daily activities and 57 videos of free play.It aims to address the research gap in existing research that pays little attention to teachers’language modeling behaviors in daily activities and free play.The results indicate that the more frequent teachers’language modeling behaviors,the larger the vocabulary young children use and the better their performance in lexical richness.However,such behaviors in daily activities and free play are infrequent and superficial,failing to guide young children’s language development effectively.To optimize teachers’language modeling behaviors in daily activities and free play,they are expected to establish positive emotional bonds with young children in a kind and respectful manner and receive training.Teachers are also encouraged to frequently communicate and engage in dialogues with young children,create contexts that facilitate the use of language,increase the frequency of stimuli for vocabulary learning,and guide and encourage young children’s advanced language.展开更多
文摘Diabetic nephropathy is one of the most common causes of end-stage renal disease worldwide and is associated with increased mortality in patients with type 1 and type 2 diabetes.Autophagy is a highly conserved"autophagy"pathway and is an important mechanism for maintaining glomerular and tubular homeostasis.Emerging evidence suggests that targeted autophagy pathway activation and restoration of autophagy activity may have renal protection.Glomerular endothelial cells are an important key factor in the development of diabetic nephropathy.Endothelial dysfunction is involved in the development of diabetic and non-diabetic glomerular injury and renal fibrosis.Evidence of glomerular endothelial dysfunction in the late stages of diabetic nephropathy,such as thrombotic microangiopathy,including impairment of glomerular capillary microaneurysms and glomerular membrane lysis autophagy,is related to the pathogenesis of diabetic nephropathy.Here,we mainly introduced the research progress of the effects of glomerular endothelial cell autophagy on diabetic nephropathy.
基金funded by the Ministry of Education of China Humanities and Social Sciences Project“Research on Strategies for Improving the Quality of Kindergarten Teacher-Child Interaction”(No.19YJA880065).
文摘Teachers’language modeling behaviors,including frequent conversation,open-ended questions,repetition and extension,self-and parallel talks,and advanced language,have significantly impacted young children’s language learning and development.This study examined 60 classrooms from 20 kindergartens in Guangzhou,China,and analyzed 62 films of daily activities and 57 videos of free play.It aims to address the research gap in existing research that pays little attention to teachers’language modeling behaviors in daily activities and free play.The results indicate that the more frequent teachers’language modeling behaviors,the larger the vocabulary young children use and the better their performance in lexical richness.However,such behaviors in daily activities and free play are infrequent and superficial,failing to guide young children’s language development effectively.To optimize teachers’language modeling behaviors in daily activities and free play,they are expected to establish positive emotional bonds with young children in a kind and respectful manner and receive training.Teachers are also encouraged to frequently communicate and engage in dialogues with young children,create contexts that facilitate the use of language,increase the frequency of stimuli for vocabulary learning,and guide and encourage young children’s advanced language.
