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白花蛇舌草多糖调节CXCL12/CXCR4轴对乳腺癌细胞增殖、迁移和侵袭的影响
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作者 覃妮 刘怡江 +4 位作者 王万平 黄丽银 覃文晖 胡正国 陆世银 《湖南中医药大学学报》 CAS 2024年第5期778-784,共7页
目的探讨白花蛇舌草多糖(Hedyotis diffusa Willd.Polysaccharide,HDP)对乳腺癌MDA-MB-231细胞增殖、迁移和侵袭的影响以及对CXCL12/CXCR4轴的调控机制。方法将乳腺癌细胞分为对照组,CXCL12/CXCR4抑制剂组(AMD 3100组),HDP低、中、高剂... 目的探讨白花蛇舌草多糖(Hedyotis diffusa Willd.Polysaccharide,HDP)对乳腺癌MDA-MB-231细胞增殖、迁移和侵袭的影响以及对CXCL12/CXCR4轴的调控机制。方法将乳腺癌细胞分为对照组,CXCL12/CXCR4抑制剂组(AMD 3100组),HDP低、中、高剂量组(HDP-L组、HDP-M组、HDP-H组),HDP高剂量+CXCL12组(HDP-H+CXCL12组);通过CCK-8检测细胞增殖情况;划痕实验、Transwell实验分别测定细胞的迁移和侵袭能力;Western blot分析细胞中上皮钙黏蛋白(E-cadherin)、波形蛋白(Vimentin)、CXCL12、CXCR4蛋白的表达;建立BALB/c-nu雌性裸鼠MDA-MB-231异种移植瘤模型并观察各组肿瘤生长情况,采用HE染色观察裸鼠移植瘤细胞的形态学特征。结果与对照组相比,AMD 3100组和HDP各剂量组细胞增殖活性、迁移和侵袭数以及Vimentin、CXCL12、CXCR4蛋白表达显著抑制(P<0.05,P<0.01),而E-cadherin蛋白表达水平明显升高(P<0.01);与HDP-H组相比,HDP-H+CXCL12组细胞的增殖活力、迁移和侵袭数以及Vimentin、CXCL12、CXCR4蛋白表达水平明显升高(P<0.01),E-cadherin蛋白表达水平被显著抑制(P<0.01)。此外,动物实验表明,与模型组相比,AMD 3100组和HDP各剂量组的肿瘤重量明显降低(P<0.05,P<0.01);与HDP-H组相比,HDP-H+CXCL12组裸鼠肿瘤重量明显增加(P<0.01);HE染色显示,AMD 3100组和HDP各干预组肿瘤组织坏死与凋亡细胞增多。结论HDP可以通过抑制CXCL12/CXCR4轴进而抑制MDA-MB-231细胞的增殖、迁移及侵袭。 展开更多
关键词 白花蛇舌草多糖 乳腺癌 异种移植瘤 CXCL12/CXCR4轴 迁移 侵袭
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庞德湘教授运用扶阳理论治疗乳腺癌经验拾粹
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作者 胡正国 吴艳秋 《基层中医药》 2023年第1期6-8,共3页
乳腺癌是女性常见肿瘤疾病,庞德湘教授认为阳不足是女性乳腺癌主要病机,而肝郁是乳腺癌的重要发病因素,两者皆贯穿乳腺癌疾病始终,其主张以扶阳理论为指导,配合疏肝法治疗乳腺癌,往往取得良效。
关键词 乳腺癌 庞德湘 临床经验
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一种小型音乐喷泉的设计制作
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作者 屈子琦 胡正国 吕诗如 《湖南工业大学学报》 2016年第6期50-54,共5页
通过对比目前各种喷泉控制系统的控制方式,利用单片机作为控制芯片设计制作一个喷泉控制系统,选用小型直流电机控制水型变化,LED彩灯进行灯光渲染,音频功放电路实现音乐播放。通过仿真测试及实物制作验证,该方法切实可行,能够很好地实... 通过对比目前各种喷泉控制系统的控制方式,利用单片机作为控制芯片设计制作一个喷泉控制系统,选用小型直流电机控制水型变化,LED彩灯进行灯光渲染,音频功放电路实现音乐播放。通过仿真测试及实物制作验证,该方法切实可行,能够很好地实现音乐、喷泉、灯光之间的配合。 展开更多
关键词 音乐喷泉 模数转换 PWM控制
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基于FSB50760SF驱动永磁同步电机驱动器的设计与实现
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作者 胡正国 易椠椠 +3 位作者 王远洋 王卫 刘亚 刘煜鸿 《湖南工业大学学报》 2018年第3期42-47,共6页
设计了一种基于FSB50760SF驱动永磁同步电机的控制器及验证电路,并将其应用在洗衣机的控制器中。测试结果表明:基于FSB50760SF驱动永磁同步电机的设计完全满足设计要求。
关键词 FSB50760SF 永磁同步电机 驱动器
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Results of Clinical Trial of Superficially-placed Tumor Therapy with Carbon Ions at Heavy Ion Research Facility in Lanzhou(HIRFL 被引量:2
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作者 Zhang Hong Li Sha +15 位作者 Wang Xiaohu Li Qiang Zhao Weiping Dai Zhongying Wei Shihua Gao Liying Xiao Guoqing Xu hushan hu zhengguo Mao Ruishi Yue Yangjun Ran Juntao Tian Zhongze Song Mingtao Zhao Hongwei Zhan Wenlong 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2007年第1期103-103,共1页
关键词 兰州重离子加速器 临床试验 重离子研究装置 治疗效果 碳离子 中国科学院 表面 肿瘤
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First Clinical Trial of Cancer Therapy with Heavy Ions at IMP 被引量:2
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作者 Zhang Hong Li Sha +9 位作者 Li Qiang Wei Shihua hu zhengguo Mao Ruishi Dai Zhongying Xu hushan Tian Zhongze Yue Yangjun ZhaoWeiping Xiao Guoqing 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2006年第1期83-83,共1页
关键词 临床试验 癌症治疗 重离子 碳离子放射
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香港特区电梯事故管理机制研究
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作者 陈江 钱剑雄 +1 位作者 胡正国 邢箭 《中国特种设备安全》 2021年第1期48-52,56,共6页
香港特区是典型的经济发达地区,电梯安全管理水平达到世界先进。通过学习香港电梯安全管理和事故管理经验,研究电梯的安全条例、守则中电梯各相关方的职责、电梯事故的管理机制,分析香港特区电梯典型的事故技术调查报告和历年的事故统... 香港特区是典型的经济发达地区,电梯安全管理水平达到世界先进。通过学习香港电梯安全管理和事故管理经验,研究电梯的安全条例、守则中电梯各相关方的职责、电梯事故的管理机制,分析香港特区电梯典型的事故技术调查报告和历年的事故统计数据,有利于加强内地与香港特区之间的技术和管理方面的深入交流,有助于给出进一步提升国家电梯安全和应急管理水平的有效措施和建议。 展开更多
关键词 香港 电梯 事故管理 事故统计分析
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An online monitor ionization chamber used in particle therapy
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作者 TANG Bin hu zhengguo +13 位作者 MAO Ruishi XU Zhiguo WANG Jiansong YUE Ke TU Xiaolin WU Dapeng CHEN Jinda ZHANG Jie WANG Meng SUN Zhiyu ZHANG Xueheng LI Qiang XU hushan XIOA Guoqing 《Nuclear Science and Techniques》 SCIE CAS CSCD 2009年第3期177-180,共4页
The clinical trials of tumor therapy using heavy ions beam 12C are now in progress at Institute of Modern Physics in Lanzhou. In order to achieve the precise radiotherapy with the high energy 12C beam in active pencil... The clinical trials of tumor therapy using heavy ions beam 12C are now in progress at Institute of Modern Physics in Lanzhou. In order to achieve the precise radiotherapy with the high energy 12C beam in active pencil beam scanning mode, we have developed an ionization chamber(IC) as an online monitor for beam intensity and also a dosimeter after calibration. Through the choosing of working gas and voltage, optimizing of the electrics and the read-out system, calibrating the linearity, the detector system provide us one of the simple and highly reliable way to monitoring the beam during the active pencil beam scanning treatments. The measurement results of this detector system show that it could work well under the condition of high energy 12C beam in active pencil beam scanning mode. 展开更多
关键词 肿瘤 治疗 临床 离子化 粒子
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An ellipsoidal time detector with PMT readout
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作者 LI Jiaxing LIU Pingping +7 位作者 WANG Jiansong XIAO Guoqing GUO Zhongyan hu zhengguo MAO Ruishi SUN Zhiyu XU hushan ZHAN Wenlong 《Nuclear Science and Techniques》 SCIE CAS CSCD 2009年第4期248-250,共3页
In this paper we present a timing detector which has low detection threshold and is radiation-resistant.The photons induced by radioactive beam ions passing through a thin plastic-scintillator foil BC422,emit from the... In this paper we present a timing detector which has low detection threshold and is radiation-resistant.The photons induced by radioactive beam ions passing through a thin plastic-scintillator foil BC422,emit from the foil center corresponding to one focal point of an aluminum ellipsoidal mirror and are reflected to another focus point at which the cathode of a photomultiplier tube locates.A time resolution of about 115 ps can be achieved for1 2N of 58.5 MeV/u and 130 ps for1 7B of 43.7 MeV/u.The counting rate up to 10 8packets per second(pps) is allowed. 展开更多
关键词 PMT 光量子 放射性 原子核物理学
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Formation Mechanism of the Tongyu Gold Deposit,Shaanxi——A Discussion of a Model for the Formation of Syntectonic Gold Deposits
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作者 hu zhengguo Qian Zhuangzhi Xi’an College of Geology, Xi’an 710054, Shaanxi Fei Zhenbi 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 1990年第4期409-425,464,共18页
The formation of the Tongyu gold deposit, controlled by regional polyphase deformation-metamorphism.is closely related to the regional composite antiform-shear slip fracture zone. Late-stage reworking of theTaihua Gro... The formation of the Tongyu gold deposit, controlled by regional polyphase deformation-metamorphism.is closely related to the regional composite antiform-shear slip fracture zone. Late-stage reworking of theTaihua Group accounts for the enrichment of ore substances. It is a typical syntectonic gold deposit. The formation and evolution of the deposit involved four stages: (Ⅰ) the state of preparation of ore sub-stances, in which primary source beds originated: (Ⅱ) the stage of remobilization of ore substances, in whichregional progressive metamorphism and migmatization and thermodynamic-chemical differentiation led toremobilization of gold and its initial local concentration: (Ⅲ) the stage of gold deposit formation, in which re-gional folding produced concordant and cross shear-slip fractures and under the dynamic action gold was sepa-rated and migrated in a certain direction and concentrated to form a gold deposit: (Ⅳ) the stage ofsuperpositon, reworking and exposure of orebodies, in which the block uplifted and the deposit againunderwent reworking through faulting and mechanical differentiation.Thermodynamic mineralization played adominant role in the formation of the deposit. 展开更多
关键词 A Discussion of a Model for the Formation of Syntectonic Gold Deposits Formation Mechanism of the Tongyu Gold Deposit Shaanxi Gold
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5 - 20 Isochronous Mass Spectrometry with Two Time-of-Flight Detectors at CSRe
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作者 Wang Meng Xu hushan +31 位作者 Zhang Yuhu Shuai Peng Zhang Wei Tu Xiaolin Xu Xing Yu. A. Litvinov K. Blaum Chen Ruijiu Chen Xiangcheng Fu Chaoyi Ge Zhuang Gao Bingshui hu zhengguo huang Wenjia S. A. Litvinov Liu Dawei Ma Xinwen Mao Ruishi Mei Bo Sun Baohua Xia Jiawen Xiao Guoqing Xing Yuanming T. Yarnaguchi Yan Xinliang Yang Jiancheng Yuan Youjin Zeng Qi Zhang Xueying Zhao Hongwei Zhao Tieeheng Zhou Xiaohong 《IMP & HIRFL Annual Report》 2013年第1期221-222,共2页
关键词 英语 阅读 理解 物理研究
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2 - 12 Elastic Scattering of 8B on natpb at 170.3 MeV
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作者 Yang Yanyun Wang Jiansong +48 位作者 Wang Qi Pang Danyang Ma Junbing huang Meirong Han Jianlong Ma Peng Jin Shilong Bai Zhen hu Qiang Jin Lei Chen Jiangbo N. Keeley K. Rusek R. Wada S. Mukherjee Sun Zhiyu Chen Ruofu Zhang Xueying hu zhengguo Yuan Xiaohua Cao Xiguang Xu Zhiguo Xu Shiwei Zhen Chuan Chen Ze Chen Size Du Chengming Duan Limin Fu Fen Gou Boxing hu Jun He Jianjun Lei Xiangguo Li Songlin Li Yong Lin Qingyong Liu Longxiang Shi Fudong Tang Shuwen Xu Ge Xu Xing Zhang Liyong Zhang Xueheng Zhang Wei Zhao Minghui Guo Zhongyan Zhang Yuhu Xu hushan Xiao Guoqing 《IMP & HIRFL Annual Report》 2013年第1期49-50,共2页
关键词 英语 阅读 理解 物理研究
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2 - 11 Elastic Scattering of 10, 11C and liB on nat pb
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作者 Yang Yanyun Wang Jiansong +28 位作者 Wang Qi Pang Danyang Ma Junbing huang Meirong Han Jianlong Ma Peng Jin Shilong Bai Zhen hu Qiang Jin Lei Chen Jiangbo R. Wada S. Mukheriee Sun Zhiyu Chen Ruofu Zhang Xueying hu zhengguo Yuan Xiaohua Xu Shiwei Chen Size Lei Xiangguo Yan Duo Zhang Xueheng Zhao Minghui Zhou Yuanjie Guo Zhongyan Zhang Yuhu Xu hushan Xiao Guoqing 《IMP & HIRFL Annual Report》 2013年第1期48-49,共2页
关键词 英语 阅读 理解 物理研究
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3 - 64 Progress of Tumor Radiotherapy with Carbon Ions at Heavy Ion Research Facility in Lanzhou (HIRFL) of IMP
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作者 Zhang Hong Li Sha +13 位作者 Wang Xiaohu Li Qiang Wei Shihua Gao Liying Zhao Weiping hu zhengguo Mao Ruishi Xu hushan Yue Yangjun Zhang Qiuning Ran Juntao Tian Zhongze Xiao Guoqing Zhan Wenlong 《IMP & HIRFL Annual Report》 2010年第1期162-163,共2页
关键词 英文摘要 内容介绍 编辑工作 期刊
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2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data
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作者 He Jianjun hu Jun +34 位作者 Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao hu zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu hushan 《IMP & HIRFL Annual Report》 2010年第1期71-72,共2页
关键词 英文摘要 内容介绍 编辑工作 期刊
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2-4 First Isochronous Mass Measurement in Neutron-rich Region at CSRe
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作者 Xu Xing Wang Meng +30 位作者 Zhang Yuhu Xu hushan Tu Xiaolin Yu.A.Litvinov Zhou Xiaohong Sun Baohua Yuan Youjin Xia Jiawen Yang Jiancheng K.Blaum Chen Ruijiu Chen Xiangchen Fu Chaoyi Ge Zhuang hu zhengguo huang Wenjia Liu Dawei Y.H.Lam Ma Xinwen Mao Ruishi T.Uesaka Xiao Guoqing Xing Yuanming T.Yamaguchi Y.Yamaguchi Zeng Qi Yan Xinliang Zhao Hongwei Zhao Tiecheng Zhang Wei Zhan Wenlong 《IMP & HIRFL Annual Report》 2014年第1期33-34,共2页
Mass is one of the fundamental properties of atomic nuclei. Isochronous mass spectrometry (IMS), using astorage ring combined with an in-flight separator, has been shown to be a powerful tool for mass measurementof ex... Mass is one of the fundamental properties of atomic nuclei. Isochronous mass spectrometry (IMS), using astorage ring combined with an in-flight separator, has been shown to be a powerful tool for mass measurementof exotic nuclei[1]. Recently, masses of many proton-rich nuclides were accurately determined at the HIRFL-CSRfacility[2]. In this paper, we described the first isochronous mass measurement of neutron-rich nuclides at CSRe.This experiment was performed at the end of 2011. In the experiment, the primary beam of 86Kr28+ ions wasaccumulated and accelerated to an energy of 460.65 MeV/u in the synchrotron CSRm. The 86Kr28+ ions were fastextracted and focused on a 15 mm thick beryllium target which was placed at the entrance of the RIBLL2 (anin-flight fragment separator). 展开更多
关键词 Isochronous MASS MEASUREMENT
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2-7 Charge and Frequency Resolved Isochronous Mass Spectrometry in Storage Rings: First Direct Mass Measurement of the Short-lived Neutron-de cient 51Co Nuclide
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作者 Shuai Peng Xu hushan +31 位作者 Tu Xiaolin Zhang Yuhu Sun Baohua Yu.A.Litvinov Yan Xinliang K.Blaum Wang Meng Zhou Xiaohong He Jianjun Sun Yang K.Kaneko Yuan Youjin Xia Jiawen Yang Jiancheng G.Audi Chen Xiangcheng Jia Guobin hu zhengguo Ma Xinwen Mao Ruishi Mei Bo Sun Zhiyu Wang Shitao Xiao Guoqing Xu Xing T.Yamaguchi Y.Yamaguchi Zang Yongdong Zhao Hongwei Zhao Tiecheng Zhang Wei Zhan Wenlong 《IMP & HIRFL Annual Report》 2014年第1期38-39,共2页
Isochronous mass spectrometry in storage rings is a successful technique for the precision mass measurements ofthe nuclides with half-lives down to tens of microseconds[1]. Since the isochronous condition =t greatly r... Isochronous mass spectrometry in storage rings is a successful technique for the precision mass measurements ofthe nuclides with half-lives down to tens of microseconds[1]. Since the isochronous condition =t greatly reducesthe influence of the velocity difference on the ion revolution periods, the revolution period difference ΔT =T ??TRof a stored ion with respect to a reference time TR is directly related to its mass-to-charge ratio difference Δ(m=q),written in the first order as: 展开更多
关键词 FREQUENCY RESOLVED Isochronous
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5-10 Investigation of the Digital Waveform Sample Techniques for the decetor
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作者 Chen Jinda Du Chengming +3 位作者 Zhang Xiuling Yang Haibo hu zhengguo Sun Zhiyu 《IMP & HIRFL Annual Report》 2014年第1期221-221,共1页
In order to satisfy high precision requirement for the modern nuclear physics experiment detectors and radiologicimaging technology equipments, we do some researches in the LaBr3 detector with digital waveform applica... In order to satisfy high precision requirement for the modern nuclear physics experiment detectors and radiologicimaging technology equipments, we do some researches in the LaBr3 detector with digital waveform application research techniques. The DRS4 board and digital waveformmethods substantially reduce the power consumption,which also are beneficial to the miniaturization ofthe data acquisition for large experiments, and to reducethe building cost. 展开更多
关键词 INVESTIGATION DIGITAL WAVEFORM
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Clinical Trial of Deep-seated Tumor Therapy with Carbon Ions at IMP
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作者 Zhang Hong Li Sha +8 位作者 Wang Xiaohu Li Qiang Wei Shihua Gao Liying Zhao Weiping hu zhengguo Mao Ruishi Xu hushan Xiao Guoqing 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2009年第1期152-153,共2页
关键词 肿瘤治疗 临床试验 进出口 碳离子 Bragg峰 剂量分布 放射治疗 穿透深度
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Investigation of Proton Resonant Properties in laNe via 17F+p and Its Astrophysical Implications for 14O(α,p)17F Stellar Reaction
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作者 hu Jun He Jianjun +34 位作者 Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Yuan Xiaohua Lu Wan Zhang Xueheng SuJun Li Ertao hu zhengguo Guo Zhongya n Xu Xing Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu hushan 《近代物理研究所和兰州重离子加速器实验室年报:英文版》 2009年第1期62-63,共2页
关键词 核天体物理 反应率 物理意义 恒星 共振线 质子 性质 能源生产
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