Background:To evaluate the efficacy and safety of donepezil and ginkgo biloba for Alzheimer5s disease.Methods:A systematic literature retrieval was carried out for eligible studies in PubMed,Embase,Cochrane Library,We...Background:To evaluate the efficacy and safety of donepezil and ginkgo biloba for Alzheimer5s disease.Methods:A systematic literature retrieval was carried out for eligible studies in PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang and China Science and Technology Journal Database from the establishment of database to 1 February 2020.Nine randomized controlled trials were included in our study in the Review Manager 5.3.Results:Our meta-analysis found that compared with donepezil alone,ginkgo biloba and donepezil could improve clinical efficacy and enhance cognitive function measured by the mini-mental state examination score.No significant difference in the total adverse reaction,the digestive symptoms and the neurological symptoms between two groups was observed.Conclusion:The combination of donepezil plus ginkgo biloba could provide more benefits for Alzheimer 5s disease patients than donepezil alone.展开更多
基金supported by the Scientific Research Project of Tianjin Education Commission,China(No.2018KJ031)National Natural Science Foundation of China(No.81704004).
文摘Background:To evaluate the efficacy and safety of donepezil and ginkgo biloba for Alzheimer5s disease.Methods:A systematic literature retrieval was carried out for eligible studies in PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang and China Science and Technology Journal Database from the establishment of database to 1 February 2020.Nine randomized controlled trials were included in our study in the Review Manager 5.3.Results:Our meta-analysis found that compared with donepezil alone,ginkgo biloba and donepezil could improve clinical efficacy and enhance cognitive function measured by the mini-mental state examination score.No significant difference in the total adverse reaction,the digestive symptoms and the neurological symptoms between two groups was observed.Conclusion:The combination of donepezil plus ginkgo biloba could provide more benefits for Alzheimer 5s disease patients than donepezil alone.
