MetarhizosidesA-G(1-7),seven new polysubstituted phenyl glucosides,were isolated from the extracts of solid rice medium of a marine-derived fungus Metarrhizium anisopliae.Compounds 1-7 all contain a polysubstituted ph...MetarhizosidesA-G(1-7),seven new polysubstituted phenyl glucosides,were isolated from the extracts of solid rice medium of a marine-derived fungus Metarrhizium anisopliae.Compounds 1-7 all contain a polysubstituted phenyl group and the sugar unit is identified as 4'-O-methyl-β-D-glucopyranose.Their structures were elucidated by NMR spectroscopy and chemical method.These compounds were evaluated for anti-inflammatory activity by using LPS-stimulated murine macrophage RAW 264.7 cells and the cytotoxicities against four human cancer cell lines.展开更多
Twenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii,including two new ones named hyperisampsins N and O(1 and 2).The structur...Twenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii,including two new ones named hyperisampsins N and O(1 and 2).The structures of 1 and 2 were elucidated by extensive NMR and mass spectrometric analyses.Their absolute configurations were further determined by using TDDFT ECD calculations.Compounds 2,7,and 8 were evaluated for their cytotoxic activities against five human cancer cell lines,of which,2 and 8 exhibited significant cytotoxic activities toward HL-60 cell and moderate activities against others cell lines.展开更多
Two pairs of chlorine-containing phenylpropanoid enantiomers(1a/1b and 2a/2b) were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers(1a/1b and 2a/2b) were co-existed in the sam...Two pairs of chlorine-containing phenylpropanoid enantiomers(1a/1b and 2a/2b) were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers(1a/1b and 2a/2b) were co-existed in the same plant, which were characterized as the first halogen-containing natural products from the genus Acorus. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis and a single-crystal X-ray diffraction, assisted by a modified Mosher's method. The phenylpropanoid isomers(1a/1b and 2a/2b) were evaluated for their antioxidant activities using DPPH assay and cytotoxic activities against five human cancer cell lines.展开更多
基金This work was financially supported by the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(No.T2016088)the National Natural Science Foundation for Distinguished Young Scholars(No.81725021)+2 种基金the National Natural Science Foundation of China(No.31900288)the Program from the(hina Postdoctoral Science Foundation(No.2019M652660)the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST,China).
文摘MetarhizosidesA-G(1-7),seven new polysubstituted phenyl glucosides,were isolated from the extracts of solid rice medium of a marine-derived fungus Metarrhizium anisopliae.Compounds 1-7 all contain a polysubstituted phenyl group and the sugar unit is identified as 4'-O-methyl-β-D-glucopyranose.Their structures were elucidated by NMR spectroscopy and chemical method.These compounds were evaluated for anti-inflammatory activity by using LPS-stimulated murine macrophage RAW 264.7 cells and the cytotoxicities against four human cancer cell lines.
基金financially supported by the Program for New Century Excellent Talents in University,State Education Ministry of China(No.NCET-2008-0224)National Science and Technology Project of China(No.2011ZX09102-004)+2 种基金the National Natural Science Foundation of China(Nos.31370372,81573316,81641129 and 21502057)the Fundamental Research Fund for the Central Universities(No.2016YXMS149)the China Postdoctoral Science Foundation(No.2015M572154)
文摘Twenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii,including two new ones named hyperisampsins N and O(1 and 2).The structures of 1 and 2 were elucidated by extensive NMR and mass spectrometric analyses.Their absolute configurations were further determined by using TDDFT ECD calculations.Compounds 2,7,and 8 were evaluated for their cytotoxic activities against five human cancer cell lines,of which,2 and 8 exhibited significant cytotoxic activities toward HL-60 cell and moderate activities against others cell lines.
基金financially supported by the Program for New Century Excellent Talents in University, State Education Ministry of China (No. NCET2008-0224)the National Natural Science Foundation of China (Nos. 31370372, 81573316, 31570361, 31200258)
文摘Two pairs of chlorine-containing phenylpropanoid enantiomers(1a/1b and 2a/2b) were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers(1a/1b and 2a/2b) were co-existed in the same plant, which were characterized as the first halogen-containing natural products from the genus Acorus. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis and a single-crystal X-ray diffraction, assisted by a modified Mosher's method. The phenylpropanoid isomers(1a/1b and 2a/2b) were evaluated for their antioxidant activities using DPPH assay and cytotoxic activities against five human cancer cell lines.