BACKGROUND The basic method of glaucoma diagnosis is visual field examination,however,in patients with high myopia,the diagnosis of glaucoma is difficult.AIM To explore the value of optical coherence tomography(OCT)fo...BACKGROUND The basic method of glaucoma diagnosis is visual field examination,however,in patients with high myopia,the diagnosis of glaucoma is difficult.AIM To explore the value of optical coherence tomography(OCT)for measuring optic disc parameters and macular thickness as a screening tool for glaucoma in patients with high myopia.METHODS Visual values(contrast sensitivity,color vision,and best-corrected visual acuity)in three groups,patients with high myopia in Group A,patients with high myopia and glaucoma in Group B,and patients with high myopia suspicious for glaucoma in Group C,were compared.Optic disc parameters,retinal nerve fiber layer(RNFL)thickness,and ganglion cell layer(GCC)thickness were measured using OCT technology and used to compare the peri-optic disc vascular density of the patients and generate receiver operator characteristic(ROC)test performance curves of the RNFL and GCC for high myopia and glaucoma.RESULTS Of a total of 98 patients admitted to our hospital from May 2018 to March 2022,totaling 196 eyes in the study,30 patients with 60 eyes were included in Group A,33 patients with 66 eyes were included in Group B,and 35 patients with 70 eyes were included in Group C.Data were processed for Groups A and B to analyze the efficacy of RNFL and GCC measures in distinguishing high myopia from high myopia with glaucoma.The area under the ROC curve was greater than 0.7,indicating an acceptable diagnostic value.CONCLUSION The value of OCT measurement of RNFL and GCC thickness in diagnosing glaucoma in patients with high myopia and suspected glaucoma is worthy of development for clinical use.展开更多
The bistratified lobula giant type 1(BLG1) neuron is an identified looming-sensitive neuron in crab's visual brain that demonstrates special sensitivity to diving targets, or descending approaching motions. In thi...The bistratified lobula giant type 1(BLG1) neuron is an identified looming-sensitive neuron in crab's visual brain that demonstrates special sensitivity to diving targets, or descending approaching motions. In this paper, a novel neural model is proposed to shape such unique selectivity through incorporating a bio-plausible feedforward contrast inhibition synapse and a radially extending spatial enhancement distribution. Herein the synaptic connections and neuronal functions of this model are placed within a framework for matching and describing underlying biological findings. The systematic and comparative experiments have validated the proposed computational model that reconciles with the characteristics of BLG1 neurons in crab.展开更多
文摘BACKGROUND The basic method of glaucoma diagnosis is visual field examination,however,in patients with high myopia,the diagnosis of glaucoma is difficult.AIM To explore the value of optical coherence tomography(OCT)for measuring optic disc parameters and macular thickness as a screening tool for glaucoma in patients with high myopia.METHODS Visual values(contrast sensitivity,color vision,and best-corrected visual acuity)in three groups,patients with high myopia in Group A,patients with high myopia and glaucoma in Group B,and patients with high myopia suspicious for glaucoma in Group C,were compared.Optic disc parameters,retinal nerve fiber layer(RNFL)thickness,and ganglion cell layer(GCC)thickness were measured using OCT technology and used to compare the peri-optic disc vascular density of the patients and generate receiver operator characteristic(ROC)test performance curves of the RNFL and GCC for high myopia and glaucoma.RESULTS Of a total of 98 patients admitted to our hospital from May 2018 to March 2022,totaling 196 eyes in the study,30 patients with 60 eyes were included in Group A,33 patients with 66 eyes were included in Group B,and 35 patients with 70 eyes were included in Group C.Data were processed for Groups A and B to analyze the efficacy of RNFL and GCC measures in distinguishing high myopia from high myopia with glaucoma.The area under the ROC curve was greater than 0.7,indicating an acceptable diagnostic value.CONCLUSION The value of OCT measurement of RNFL and GCC thickness in diagnosing glaucoma in patients with high myopia and suspected glaucoma is worthy of development for clinical use.
基金supported by the National Natural Science Foundation of China (No.12031003)the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant Agreement (No.778062 ULTRACEPT)。
文摘The bistratified lobula giant type 1(BLG1) neuron is an identified looming-sensitive neuron in crab's visual brain that demonstrates special sensitivity to diving targets, or descending approaching motions. In this paper, a novel neural model is proposed to shape such unique selectivity through incorporating a bio-plausible feedforward contrast inhibition synapse and a radially extending spatial enhancement distribution. Herein the synaptic connections and neuronal functions of this model are placed within a framework for matching and describing underlying biological findings. The systematic and comparative experiments have validated the proposed computational model that reconciles with the characteristics of BLG1 neurons in crab.