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Ocular bacterial infections at a tertiary eye center in China: a 5-year review of pathogen distribution and antibiotic sensitivity 被引量:7
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作者 Wen Gao Tian Xia +5 位作者 hua-bo chen Xiao-Jing Pan Yu-Sen Huang Xin Wang Yan-Ling Dong Li-Xin Xie 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2020年第1期54-60,共7页
AIM: To provide statistical evidence for the use of antibiotics in ophthalmology by assessing the distribution and antibiotic sensitivity of bacterial isolates from ocular specimens with suspected microbial infections... AIM: To provide statistical evidence for the use of antibiotics in ophthalmology by assessing the distribution and antibiotic sensitivity of bacterial isolates from ocular specimens with suspected microbial infections.METHODS: This study applied a retrospective analysis of 3690 bacterial isolates from ocular specimens, which were obtained from the conjunctiva, cornea, aqueous humor, vitreous body, and other ocular sites of the patients at Shandong Eye Institute in northern China from January 2013 to December 2017. The parameters assessed mainly included the distribution of isolated bacteria and the results of susceptibility tests for antibiotics. In the analysis of antibiotic sensitivities, the bacteria were divided into four groups according to gram staining, and statistical methods were used to compare their antibiotic sensitivities. RESULTS: Among the 3690 isolated bacterial strains, Staphylococcus epidermidis(2007, 54.39%) accounted for the highest proportion. As for the total isolates, their sensitivity rate to gatifloxacin was up to 90.01%, with four types of gram-stained bacteria being all highly sensitive to it, but their sensitivity rate to levofloxacin was only 51.91%. The sensitivity rate of gram-negative bacilli(G-B) to levofloxacin was 83.66%, significantly higher than the other three types of gram-stained bacteria(P<0.05). Gram-positive cocci (G+C, 97.95%) and gram-positive bacilli(G+B, 97.54%) were more sensitive to vancomycin than gram-negative cocci(G-C, 70.59%) and G-B(68.57%;P<0.05). For fusidic acid, the sensitivity rates of G+C(89.83%) and G+B(73.37%) were significantly higher than that of G-B(29.83%;P<0.05). The gram-negative bacteria's sensitivity rate to cefuroxime was as low as 59.25%, but only G-B was less sensitive to cefuroxime(57.28%), while G-C was still highly sensitive(89.29%). The sensitivity rate of gram-positive bacteria to moxifloxacin was as high as 80.28%, but only G+C was highly sensitive to moxifloxacin(81.21%), while G+B was still less sensitive(32.00%). CONCLUSION: Staphylococcus epidermidis is the predominant isolate in all ocular specimens with bacteria. Gatifloxacin is more suitable for topical prophylactic use than levofloxacin in ophthalmology when necessar y. Vancomycin and fusidic acid both have better effects on gram-positive bacteria than gram-negative bacteria. More accurate antibiotic sensitivity analysis results can be obtained when a more detailed bacterial classification and more appropriate statistical methods are performed. 展开更多
关键词 BACTERIA ocular infections PATHOGEN antibiotic sensitivity
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Nitrogen-rich metal-organic framework mediated Cu-N-C composite catalysts for the electrochemical reduction of CO_(2) 被引量:2
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作者 Si-Min Cao hua-bo chen +7 位作者 Bao-Xia Dong Qiu-Hui Zheng Yan-Xia Ding Meng-Jie Liu She-Liang Qian Yun-Lei Teng Zong-Wei Li Wen-Long Liu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第3期555-563,共9页
Cu-based MOFs,i.e.,HKUST-1,etc.,have been pertinently chosen as the pristine materials for CO_(2) ER due to the unique ability of copper for generation hydrocarbon fuel.However,the limited conductivity and stability b... Cu-based MOFs,i.e.,HKUST-1,etc.,have been pertinently chosen as the pristine materials for CO_(2) ER due to the unique ability of copper for generation hydrocarbon fuel.However,the limited conductivity and stability become the stumbling-block that prevents the development of it.The exploring of MOFsderived M-C materials starts a new chapter for the MOFs precursors,which provides a remarkable electronic connection between carbon matrix and metals/metal oxides.N-doped M-N-C with extensive M-N sites scattering into the carbon matrix are more popular because of their impressive contribution to catalytic activity and specific product selectivity.Nevertheless,Cu-N-C system remained undeveloped up to now.The lack of ideal precursor,the sensitivity of Cu to be oxidized,and the difficulties in the synthesis of small size Cu nanoparticles are thus known as the main barriers to the development of Cu-N-C electrocatalysts.Herein,a nitrogen-rich Cu-BTT MOF is employed for the derivation of N-doped Cu-N-CT composite electrocatalysts by the pyrolyze method.High-temperature pyrolysis product of Cu-N-C1100exhibits the best catalytic activity for productions of CO(-0.6 V vs.RHE,jCO=0.4 mA/cm^(2))and HCOOH(-0.9 V vs.RHE,jHCOOH=1.4 mA/cm^(2)). 展开更多
关键词 Carbon mono-oxide Formic acid Metal-organic framework Nitrogen-rich Copper nanoparticle CATALYST
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