Integrated sensor based on acoustics-electricity-mechanics coupling effect for wireless passive gas detection

Integrated sensor combines multiple sensor functions into a single unit,which has the advantages of miniaturization and better application potential.However,limited by the sensing platforms of the sensor and the selectivity of the sensitive film,there are still challenges to realize multi-component gas detection in one unit.Herein,a principle integration method is proposed to achieve the multi-component gas detection based on the acoustics-electricity-mechanics coupling effect.The electrical and mechanical properties of the Bi_(2)S_(3)nanobelts materials in different atmospheres indicate the possibility of realizing the principle integration.At the same time,the surface acoustic wave(SAW)sensor as a multivariable physical transducer can sense both electrical and mechanical properties.Upon exposure to 10 ppm NO_(2),NH_(3),and their mixtures,the integrated SAW gas sensor shows a 4.5 kHz positive frequency shift(acoustoelectric effect),an 11 kHz negative frequency shift(mechanics effects),and a reduced 4 kHz negative frequency shift(acoustics-electricity-mechanics coupling effect),respectively.Moreover,we realize wireless passive detection of NO_(2)and NH_(3)based on the SAW sensor.Our work provides valuable insights that can serve as a guide to the design and fabrication of single sensors offering multi-component gas detection via different gas sensing mechanisms.

Progress in the expression of P-glycoprotein in brain metastases of lung cancer andrelated TCM research

Brain metastases are common intracranial tumors, and their occurrence not only represents a high degree of malignancy, but also often is the major factor in treatment failure and poor prognosis. Primary site of brain metastases often occur in lung. P-glycoprotein is a member of the （ATP binding cassette） transporter superfamily,which is closely related to the development of lung metastases. It is the main reason for influencing the drug through the blood_brain barrier into the brain tissue, and it also is an important factor affecting the treatment of brain metastases. According to the theory of traditional chinese mddicine, the pathogenesis of brain metastases is due to phlegm, poison, stasis, virtual and so on. The principle of treatment is to promote blood circulation, remove phlegm turbidity. In recent years, the impact of Chinese herbal medicine on P-glycoprotein is increasing. This paper analyzes the mechanism and components of the relevant Chinese medicine on P-glycoprotein. It provides a reference for clinical rational drug use.

Electrochemical protein biosensors for disease marker detection:progress and opportunities

The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology.Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects.Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in immunology.However,the active centers of protein biomarkers are surrounded by a peptide matrix,which hinders charge transfer and results in insufficient sensor sensitivity.Therefore,electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein sensors.In this review,we summarize recent reports of electrochemical biosensors for protein biomarker detection.We highlight the latest research on electrochemical protein biosensors for the detection of cancer,viral infectious diseases,inflammation,and other diseases.The corresponding sensitive materials,transducer structures,and detection principles associated with such biosensors are also addressed generally.Finally,we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

Electrochemical biosensor employing PbS colloidal quantum dots/Au nanospheres-modified electrode for ultrasensitive glucose detection

Rapid and accurate detection of glucose is of great significance for diabetic management.Highly sensitive glucose sensors promise to achieve noninvasive detection technology,enabling more convenient and efficient means for large-scale screening and long-term dynamic monitoring of diabetes patients.In this work,we demonstrate a sensitive glucose electrochemical biosensor through the synergetic labelling strategy utilizing PbS colloidal quantum dots(CQDs)and Au nanospheres(AuNSs).The PbS CQDs/AuNSs/glucose oxidase(GOx)mixture could be stably immobilized on the carbon electrode surface via the onestep dip-coating method.The electrochemical biosensor employing PbS CQDs/AuNSs/GOx-modified electrode integrates the functions of specific molecule recognition,signal transduction as well as signal amplification.The sensor is capable of transducing the glucose enzyme-catalyzed reaction into significant current signals,exhibiting a good linear response in the glucose concentration range of 0.1μM-10 mM with the limit of detection being 1.432 nM.