Two types of one-dimensional(1D)anti-PT-symmetric periodic ring optical waveguide networks,consisting of gain and loss materials,are constructed.The singular optical propagation properties of these networks are invest...Two types of one-dimensional(1D)anti-PT-symmetric periodic ring optical waveguide networks,consisting of gain and loss materials,are constructed.The singular optical propagation properties of these networks are investigated.The results show that the system composed of gain materials exhibits characteristics of ultra-strong transmission and bidirectional reflection.Conversely,the system composed of loss materials demonstrates equal transmittance and reflectance at some frequencies.In both the systems,a new type of total reflection phenomenon is observed.When the imaginary part of the refractive indices of waveguide segments is smaller than 10-5,the system shows bidirectional transparency with the transmittance tending to be 1 and reflectivity to be smaller than 10-8 at some bands.When the refractive indices of the waveguide segments are real,the system will be bidirectional transparent at the full band.These findings may deepen the understanding of anti-PT-symmetric optical systems and optical waveguide networks,and possess potential applications in efficient optical energy storage,ultra-sensitive optical filters,ultra-sensitive all-optical switches,integrated optical chips,stealth physics,and so on.展开更多
As phase separation between the small-molecule semiconductor and the polymer binder is the key enabler of blend-based organic field-effect transistors(OFETs)fabricated by low-cost solution processing,it is crucial to ...As phase separation between the small-molecule semiconductor and the polymer binder is the key enabler of blend-based organic field-effect transistors(OFETs)fabricated by low-cost solution processing,it is crucial to understand the underlying phase separation mechanisms that determine the phase morphology,which significantly impacts device performance.Beyond the parameter space investigated in previous work,here we investigate the formation of blends by varying the branch architecture of the polymer binder and by shortening the solvent dry time using ultrasonic spray casting.The phase morphologies of the resulting blend films have been thoroughly characterized with a variety of techniques in three dimensions over multiple length scales,including AFM,energy-filtered transmission electron microscope,and neutron reflectivity,and have been correlated with electrical transport performance.From the results,we have inferred that the phase morphology is kinetically determined,limited by the inherent slow movement of polymer macromolecules.The kinetic picture,supported by molecular dynamics modeling,not only consistently explains our observations but also resolves inconsistencies in previous works.The achieved mechanistic understanding will guide further optimization of blend-based organic electronics,such as OFETs and organic photovoltaics.展开更多
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface.Here,we used in situ fluorescence resonance energy transfer(FRET)to measure the distances of single...A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface.Here,we used in situ fluorescence resonance energy transfer(FRET)to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζreceptors at the membranes of live primary T cells.We found that a TCR discriminates between closely related peptides by forming single TCR–pMHC bonds with different conformations,and the most potent pMHC forms the shortest bond.The bond conformation is an intrinsic property that is independent of the binding affinity and kinetics,TCR microcluster formation,and CD4 binding.The bond conformation dictates the degree of CD3ζdissociation from the inner leaflet of the plasma membrane via a positive calcium signaling feedback loop to precisely control the accessibility of CD3ζITAMs for phosphorylation.Our data revealed the mechanism by which a TCR deciphers the structural differences among peptides via the TCR–pMHC bond conformation.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11674107,61475049,11775083,61774062,and 61771205).
文摘Two types of one-dimensional(1D)anti-PT-symmetric periodic ring optical waveguide networks,consisting of gain and loss materials,are constructed.The singular optical propagation properties of these networks are investigated.The results show that the system composed of gain materials exhibits characteristics of ultra-strong transmission and bidirectional reflection.Conversely,the system composed of loss materials demonstrates equal transmittance and reflectance at some frequencies.In both the systems,a new type of total reflection phenomenon is observed.When the imaginary part of the refractive indices of waveguide segments is smaller than 10-5,the system shows bidirectional transparency with the transmittance tending to be 1 and reflectivity to be smaller than 10-8 at some bands.When the refractive indices of the waveguide segments are real,the system will be bidirectional transparent at the full band.These findings may deepen the understanding of anti-PT-symmetric optical systems and optical waveguide networks,and possess potential applications in efficient optical energy storage,ultra-sensitive optical filters,ultra-sensitive all-optical switches,integrated optical chips,stealth physics,and so on.
文摘As phase separation between the small-molecule semiconductor and the polymer binder is the key enabler of blend-based organic field-effect transistors(OFETs)fabricated by low-cost solution processing,it is crucial to understand the underlying phase separation mechanisms that determine the phase morphology,which significantly impacts device performance.Beyond the parameter space investigated in previous work,here we investigate the formation of blends by varying the branch architecture of the polymer binder and by shortening the solvent dry time using ultrasonic spray casting.The phase morphologies of the resulting blend films have been thoroughly characterized with a variety of techniques in three dimensions over multiple length scales,including AFM,energy-filtered transmission electron microscope,and neutron reflectivity,and have been correlated with electrical transport performance.From the results,we have inferred that the phase morphology is kinetically determined,limited by the inherent slow movement of polymer macromolecules.The kinetic picture,supported by molecular dynamics modeling,not only consistently explains our observations but also resolves inconsistencies in previous works.The achieved mechanistic understanding will guide further optimization of blend-based organic electronics,such as OFETs and organic photovoltaics.
基金This work was mainly supported by NIH grants R00AI106941 and R21AI120010NSF CAREER Award 1653782,a Chicago Biomedical Consortium Catalyst Award(to J.H.)+1 种基金postdoctoral grant PDR-092(to D.K.S.),with additional support from the Searle Funds at The Chicago Community TrustThis work is also supported by NIH grant R01AI126756(to E.J.A.)and R01CA022677(to H.S.).
文摘A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface.Here,we used in situ fluorescence resonance energy transfer(FRET)to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζreceptors at the membranes of live primary T cells.We found that a TCR discriminates between closely related peptides by forming single TCR–pMHC bonds with different conformations,and the most potent pMHC forms the shortest bond.The bond conformation is an intrinsic property that is independent of the binding affinity and kinetics,TCR microcluster formation,and CD4 binding.The bond conformation dictates the degree of CD3ζdissociation from the inner leaflet of the plasma membrane via a positive calcium signaling feedback loop to precisely control the accessibility of CD3ζITAMs for phosphorylation.Our data revealed the mechanism by which a TCR deciphers the structural differences among peptides via the TCR–pMHC bond conformation.