Vaccination inhibits TLR2 transcription via suppression of GR nuclear translocation and binding to TLR2 promoter in porcine lung infected with Mycoplasma hyopneumoniae

Toll-like receptors(TLRs)and glucocorticoid receptor(GR)act as effectors of innate immune system and neuroendocrine system,respectively.The crosstalk between these two receptors is important to maintain homeostasis during immune response.It is well known that vaccination can boost adaptive immune responses to specific pathogens.However,it remains elusive whether and