The calcium channel blocker,verapamil,has been shown to reduce scar formation by inhibiting fibroblast adhesion and proliferation in vitro.It was not clear whether topical application of verapamil after surgical repai...The calcium channel blocker,verapamil,has been shown to reduce scar formation by inhibiting fibroblast adhesion and proliferation in vitro.It was not clear whether topical application of verapamil after surgical repair of the nerve in vivo could inhibit the formation of excessive scar tissue.In this study,the right sciatic nerve of adult Sprague-Dawley rats was transected and sutured with No.10-0 suture.The stoma was wrapped with gelfoam soaked with verapamil solution for 4 weeks.Compared with the control group(stoma wrapped with gelfoam soaked with physiological saline),the verapamil application inhibited the secretion of extracellular matrix from fibroblasts in vivo,suppressed type I and III collagen secretion and increased the total number of axons and the number of myelinated axons.These findings suggest that verapamil could reduce the formation of scar tissue and promote axon growth after peripheral nerve repair.展开更多
The most common cytotoxic effects of chemotherapy drugs alone include bone marrow suppression,gastrointestinal symptoms,and liver and kidney function problems.With the continuous research on non-small cell lung cancer...The most common cytotoxic effects of chemotherapy drugs alone include bone marrow suppression,gastrointestinal symptoms,and liver and kidney function problems.With the continuous research on non-small cell lung cancer(NSCLC),various treatment modalities such as targeted therapy and immunotherapy have emerged in recent years,but there is no denying that chemotherapy remains one of the most basic treatment modalities.Shen Jia et al.,in exploring the efficacy of detoxification and yin clearing soup(Astragalus membranaceus(Fisch.)Bunge,Atractylodes macrocephala Koidz,et al.),found that the addition of the soup treatment significantly reduced the number of adverse reactions such as bone marrow suppression,nausea and vomiting,and abnormal liver and kidney function,and the incidence of adverse reactions was also significantly lower than that of the group with chemotherapy drugs alone[1].展开更多
Colon cancer is currently a highly prevalent cancer with a high mortality rate worldwide.Modern medical technology provides a range of treatments for colon cancer through different means,and research on the modulating...Colon cancer is currently a highly prevalent cancer with a high mortality rate worldwide.Modern medical technology provides a range of treatments for colon cancer through different means,and research on the modulating adjuvant treatment of colon cancer with Chinese medicine is currently undergoing continuous theoretical and practical exploration to find highly effective herbal remedies to modulate,alleviate or treat the disease.The present study reviews different aspects of colon cancer in relation to different factors and the modulating adjuvant treatment of colon cancer with Chinese medicine.展开更多
Background Mitogen-inducible gene 6(Mig6),also known as RALT or gene 33,is a multiadaptive protein implicated in the regulation of RTK and stress signaling 1-3.In recent years,the negative control of RTK signaling has...Background Mitogen-inducible gene 6(Mig6),also known as RALT or gene 33,is a multiadaptive protein implicated in the regulation of RTK and stress signaling 1-3.In recent years,the negative control of RTK signaling has piqued the interest of researchers.with an increasing number of negative feedback regulators of tyrosine kinase(Receptor Protein Tyrosine Kinase,RTK).Although several commonly used inhibitors have been identified at this stage,this merely emphasizes the significance of signal attenuation and regulation for proper signal output.However,the mechanisms of their action are not well understood,especially those in vivo function and metabolic expression.展开更多
基金supported by the Natural Science Foundation of Hubei Province of China,No.2011CDB392
文摘The calcium channel blocker,verapamil,has been shown to reduce scar formation by inhibiting fibroblast adhesion and proliferation in vitro.It was not clear whether topical application of verapamil after surgical repair of the nerve in vivo could inhibit the formation of excessive scar tissue.In this study,the right sciatic nerve of adult Sprague-Dawley rats was transected and sutured with No.10-0 suture.The stoma was wrapped with gelfoam soaked with verapamil solution for 4 weeks.Compared with the control group(stoma wrapped with gelfoam soaked with physiological saline),the verapamil application inhibited the secretion of extracellular matrix from fibroblasts in vivo,suppressed type I and III collagen secretion and increased the total number of axons and the number of myelinated axons.These findings suggest that verapamil could reduce the formation of scar tissue and promote axon growth after peripheral nerve repair.
基金This work was supported by National Natural Science Foundation of China(81360684)Guangxi Key Research and Development Program Project(Guike AB18221095)+2 种基金Teaching Master Teacher Training Program Project of the Right River School of Ethnic Medicine-National Teaching Master Teacher Training Program Project(Right Hospital Word[2018]No.98)High-level Talent Scientific Research Project of the Right River School of Ethnic Medicine(01002018079).National and autonomous region level college student innovation and entrepreneurship training program project fund funding project(No.:202010599030)autonomous region level college student innovation and entrepreneurship training program project fund funding project(No.:20110599065)。
文摘The most common cytotoxic effects of chemotherapy drugs alone include bone marrow suppression,gastrointestinal symptoms,and liver and kidney function problems.With the continuous research on non-small cell lung cancer(NSCLC),various treatment modalities such as targeted therapy and immunotherapy have emerged in recent years,but there is no denying that chemotherapy remains one of the most basic treatment modalities.Shen Jia et al.,in exploring the efficacy of detoxification and yin clearing soup(Astragalus membranaceus(Fisch.)Bunge,Atractylodes macrocephala Koidz,et al.),found that the addition of the soup treatment significantly reduced the number of adverse reactions such as bone marrow suppression,nausea and vomiting,and abnormal liver and kidney function,and the incidence of adverse reactions was also significantly lower than that of the group with chemotherapy drugs alone[1].
基金This work was supported by National Natural Science Foundation of China(No.81360684)Guangxi Key Research and Development Plan Project(Gui Ke AB18221095)+3 种基金Teaching Teacher Training Project from Youjiang Medical University for Nationalities-National Teaching TeacherTraining Project(You Hospital Zi[2018]No.98)High-level Talent Research Projects from Youjiang Medical University For Nationalities(No.01002018079)China National and Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599022)China Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599065).
文摘Colon cancer is currently a highly prevalent cancer with a high mortality rate worldwide.Modern medical technology provides a range of treatments for colon cancer through different means,and research on the modulating adjuvant treatment of colon cancer with Chinese medicine is currently undergoing continuous theoretical and practical exploration to find highly effective herbal remedies to modulate,alleviate or treat the disease.The present study reviews different aspects of colon cancer in relation to different factors and the modulating adjuvant treatment of colon cancer with Chinese medicine.
基金supported by National Natural Science Foundation of China(No.81360684)Guangxi Key Research and Development Plan Project(Gui Ke AB18221095)+3 种基金Teaching Teacher Training Project from Youjiang Medical University for Nationalities-National Teaching Teacher Training Project(You Hospital Zi[2018]No.98)High-level Talent Research Projects from Youjiang Medical University For Nationalities(No.01002018079)China National and Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.201910599012)China Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.202010599072).
文摘Background Mitogen-inducible gene 6(Mig6),also known as RALT or gene 33,is a multiadaptive protein implicated in the regulation of RTK and stress signaling 1-3.In recent years,the negative control of RTK signaling has piqued the interest of researchers.with an increasing number of negative feedback regulators of tyrosine kinase(Receptor Protein Tyrosine Kinase,RTK).Although several commonly used inhibitors have been identified at this stage,this merely emphasizes the significance of signal attenuation and regulation for proper signal output.However,the mechanisms of their action are not well understood,especially those in vivo function and metabolic expression.