When solving the routing problem with traditional ant colony algorithm, there is scarce in initialize pheromone and a slow convergence and stagnation for the complex network topology and the time-varying characteristi...When solving the routing problem with traditional ant colony algorithm, there is scarce in initialize pheromone and a slow convergence and stagnation for the complex network topology and the time-varying characteristics of channel in power line carrier communication of low voltage distribution grid. The algorithm is easy to fall into premature and local optimization. Proposed an automatic network algorithm based on improved transmission delay and the load factor as the evaluation factors. With the requirements of QoS, a logical topology of power line communication network is established. By the experiment of MATLAB simulation, verify that the improved Dynamic hybrid ant colony genetic algorithm (DH_ACGA) algorithm has improved the communication performance, which solved the QoS routing problems of power communication to some extent.展开更多
DNA sequencers have become increasingly important research and diagnostic tools over the past 20 years.In this study,we developed a single-molecule desktop sequencer,GenoCare 1600(GenoCare),which utilizes amplificatio...DNA sequencers have become increasingly important research and diagnostic tools over the past 20 years.In this study,we developed a single-molecule desktop sequencer,GenoCare 1600(GenoCare),which utilizes amplification-free library preparation and two-color sequencing-by-synthesis chemistry,making it more user-friendly compared with previous single-molecule sequencing platforms for clinical use.Using the GenoCare platform,we sequenced an Escherichia coli standard sample and achieved a consensus accuracy exceeding 99.99%.We also evaluated the sequencing performance of this platform in microbial mixtures and coronavirus disease 2019(COVID-19)samples from throat swabs.Our findings indicate that the GenoCare platform allows for microbial quantitation,sensitive identification of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus,and accurate detection of virus mutations,as confirmed by Sanger sequencing,demonstrating its remarkable potential in clinical application.展开更多
Induction of cancer cell ferroptosis has been proposed as a potential treatment in several cancer types.Tumor-associated macrophages(TAMs)play a key role in promoting tumor malignant progression and therapy resistance...Induction of cancer cell ferroptosis has been proposed as a potential treatment in several cancer types.Tumor-associated macrophages(TAMs)play a key role in promoting tumor malignant progression and therapy resistance.However,the roles and mechanisms of TAMs in regulating tumor ferroptosis is still unexplored and remains enigmatic.This study shows ferroptosis inducers has shown therapeutic outcomes in cervical cancer in vitro and in vivo.TAMs have been found to suppress cervical cancer cells ferroptosis.Mechanistically,macrophage-derived miRNA-660-5p packaged into exosomes are transported into cancer cells.In cancer cells,miRNA-660-5p attenuates ALOX15 expression to inhibit ferroptosis.Moreover,the upregulation of miRNA-660-5p in macrophages depends on autocrine IL4/IL13-activated STAT6 pathway.Importantly,in clinical cervical cancer cases,ALOX15 is negatively associated with macrophages infiltration,which also raises the possibility that macrophages reduce ALOX15 levels in cervical cancer.Moreover,both univariate and multivariate Cox analyses show ALOX15 expression is independent prognostic factor and positively associated with good prognosis in cervical cancer.Altogether,this study reveals the potential utility of targeting TAMs in ferroptosis-based treatment and ALOX15 as prognosis indicators for cervical cancer.展开更多
In order to utilize high‐temperature superconducting Yttrium Barium Copper Oxide(YBCO)tapes to develop superconducting cables for high magnet field applications,it is critical to ensure the stable operation of the YB...In order to utilize high‐temperature superconducting Yttrium Barium Copper Oxide(YBCO)tapes to develop superconducting cables for high magnet field applications,it is critical to ensure the stable operation of the YBCO cable under challenging mechanical and thermal conditions.A new type of cable featuring the winding of YBCO and copper tapes around a spiral stainless steel tube has been proposed to increase flexibility and cooling.Experiments are performed to confirm that its critical current varies with the bending diameter.The cables wound with nine YBCO tapes in three layers show a critical current degradation of less than 5%for a bending diameter of 30 mm.The performance of the cable degrades as the number of wound layers increases.The critical current degradation of cable specimens wound from 15 tapes in five layers reached approximately 12%for a bending diameter of 30 mm.In addition,when compared to traditional CORC cable specimens,the developed cable specimens show better‐bending flexibility and achieve a lower critical bending diameter.The finite element models show that the higher elasticity coefficient and lower plasticity of the stainless steel spiral tube results in a lower strain on the YBCO tapes of the HFRC cable than that of the CORC cable,and the maximum strain on the YBCO tapes of the HFRC cable was only about 10%of that of the CORC cable.Therefore,it is less likely that the YBCO tape in this type of cable will reach the irreversible strain limit during bending,resulting in a degradation in current carrying performance.Furthermore,the cooling efficiency can be improved by flowing the cooling medium inside the central core,which can significantly improve its thermal stability.These advantages indicate the possibility of using it in future high‐field magnets with high current carrying capacity at fields greater than 15 T.展开更多
A power-transmission collection line is connected to each wind turbine of a wind farm and then connected to the incoming switchgear at the low-voltage side of the booster station at a certain distance.Therefore,the gr...A power-transmission collection line is connected to each wind turbine of a wind farm and then connected to the incoming switchgear at the low-voltage side of the booster station at a certain distance.Therefore,the grouping of the wind turbines in the wind farm determines the layout of the lines and affects the line impedance.The line structure and composition of the wind farm are analyzed,and the relationship between the impedance of the collection line and reactive power generated by the wind turbine at low-voltage ride through is derived.We conclude that the smaller the equivalent impedance of the wind farm collection line structure is,the greater the reactive power at the wind farm collection line point is.In addition,the economic aspect of the collection line needs to be considered in the design.The economic aspect and impedance values have contrasting characteristics.Therefore,according to the condition of minimum impedance and optimized economic aspect,an optimization model of a wind-farm collector-circuit structure is proposed.The optimal structure of the wind farm collector circuit is calculated using the Monte Carlo method,and the theoretical analysis is verified by simulation.展开更多
High Temperature Superconductor(HTS)materials can operate at higher magnetic fields up to 20 T with high critical current and higher operating temperature,compared to low temperature superconductors(LTS).A Highly Flex...High Temperature Superconductor(HTS)materials can operate at higher magnetic fields up to 20 T with high critical current and higher operating temperature,compared to low temperature superconductors(LTS).A Highly Flexible REBCO Cable(HFRC)is introduced at the Institute of Plasma Physics,Chinese Academy of Sciences(ASIPP);a cabling method that is suitable for REBCO HTS tape having anisotropic material properties in its thin REBCO layer.This type of HTS superconducting cable shows high potential for applications in nuclear fusion.The alternating currents and magnetic fields in tokamak type of fusion magnets,cause AC power losses in such cables,which can provoke instability of the conductor by induced currents and increase the temperature.As a first step in characterizing the electromagnetic(EM)performance of an HFRC cable,the AC loss and contact resistance of the HFRC prototype cable were measured at the University of Twente.The measurements were done in liquid helium(4.2 K)with AC magnetic fields,applied perpendicular to the cable's long axis.The AC loss was measured simultaneously by a calibrated gas flow calorimeter utilizing the helium boil-off method,and by the magnetization method using pick-up coils.For the applied test conditions,no coupling loss could be distinguished as a part of the overall AC loss.It is suggested that this might be explained by the shielding of the conductor interior from the applied magnetic field by the outer tape layer due to the high critical current density of the REBCO tape,leading to a high penetration field.展开更多
The publication of The Tat'ping Heavenly Chronicle (Taiping tianr) in 1862 marks a critical moment in the development of the Taiping propaganda machine. Printed with copper plate printing technology that evinces im...The publication of The Tat'ping Heavenly Chronicle (Taiping tianr) in 1862 marks a critical moment in the development of the Taiping propaganda machine. Printed with copper plate printing technology that evinces imperial authority, this text is the only official history written by the Taipings in their quest to institute an overarching narrative of the movement. A systematic description of the origin and nature of the Taiping movement, The Taiping Heavenly Chronicle aims to establish Hong Xiuquan as the sole religious and political leader after the internecine Tianjing Incident (1856), which radically restructured the Taiping leadership. Using imagery, popular literary tropes, and narrative devices, this text incorporates the heterogeneous elements found in the Christian-inspired Taiping discourse to rewrite thousands of years of Chinese history.展开更多
Due to the high current capability and excellent flexibility,High Flexible REBCO Cables(HFRC)have emerged as an important candidate for composite high‐temperature superconducting conductors.The REBCO six around one C...Due to the high current capability and excellent flexibility,High Flexible REBCO Cables(HFRC)have emerged as an important candidate for composite high‐temperature superconducting conductors.The REBCO six around one Cable‐In‐Conduit Conductor(CICC)concept has been designed for application in the Central Solenoid(CS)coil of the China Fusion Engineering Test Reactor.In the application of fusion devices,the performance of CICC under electromagnetic(EM)loading and thermal stress is very important for reliable and economic operation.Therefore,a 1.22 m long sub‐cable with HFRC design for CICC was manufactured and tested at 4.2 K in a background magnetic field up to 5.8 T.The aim is to investigate the stability of the current‐carrying properties of the HFRC cable under electromagnetic and thermal cyclic loading.The test results show that the critical current(I_(c))of the HFRC cable reached 17.3 kA in a background magnetic field of 5.8 T at 4.2 K.Furthermore,no performance degradation was observed after 24 cycles of 80 kN/m peak load with a background field of 5.8 T and 8 warm‐up‐cool‐down cycles between 77 K and room temperature.The test results provide a good basis for the development of full‐size conductors in future magnet applications.展开更多
文摘When solving the routing problem with traditional ant colony algorithm, there is scarce in initialize pheromone and a slow convergence and stagnation for the complex network topology and the time-varying characteristics of channel in power line carrier communication of low voltage distribution grid. The algorithm is easy to fall into premature and local optimization. Proposed an automatic network algorithm based on improved transmission delay and the load factor as the evaluation factors. With the requirements of QoS, a logical topology of power line communication network is established. By the experiment of MATLAB simulation, verify that the improved Dynamic hybrid ant colony genetic algorithm (DH_ACGA) algorithm has improved the communication performance, which solved the QoS routing problems of power communication to some extent.
文摘DNA sequencers have become increasingly important research and diagnostic tools over the past 20 years.In this study,we developed a single-molecule desktop sequencer,GenoCare 1600(GenoCare),which utilizes amplification-free library preparation and two-color sequencing-by-synthesis chemistry,making it more user-friendly compared with previous single-molecule sequencing platforms for clinical use.Using the GenoCare platform,we sequenced an Escherichia coli standard sample and achieved a consensus accuracy exceeding 99.99%.We also evaluated the sequencing performance of this platform in microbial mixtures and coronavirus disease 2019(COVID-19)samples from throat swabs.Our findings indicate that the GenoCare platform allows for microbial quantitation,sensitive identification of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus,and accurate detection of virus mutations,as confirmed by Sanger sequencing,demonstrating its remarkable potential in clinical application.
基金supported by the National Natural Science Foundation of China(81972479,U2004118,82072899,81772643 and 81772803)Natural Science Foundation of Guangdong province(2019A1515011100 and 2021A1515012576,China)+5 种基金Henan Natural Science Foundation(202300410359,China)Henan Medical Program(SBGJ2020002081,China)Guangzhou High-Level Clinical Key Specialty Construction ProjectClinical Key Specialty Construction Project of Guangzhou Medical University(202005,China)the Innovation Project of Universities in Guangdong Province(NO.2021KTSCX026,China)Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(QNCXTD2023019,China)。
文摘Induction of cancer cell ferroptosis has been proposed as a potential treatment in several cancer types.Tumor-associated macrophages(TAMs)play a key role in promoting tumor malignant progression and therapy resistance.However,the roles and mechanisms of TAMs in regulating tumor ferroptosis is still unexplored and remains enigmatic.This study shows ferroptosis inducers has shown therapeutic outcomes in cervical cancer in vitro and in vivo.TAMs have been found to suppress cervical cancer cells ferroptosis.Mechanistically,macrophage-derived miRNA-660-5p packaged into exosomes are transported into cancer cells.In cancer cells,miRNA-660-5p attenuates ALOX15 expression to inhibit ferroptosis.Moreover,the upregulation of miRNA-660-5p in macrophages depends on autocrine IL4/IL13-activated STAT6 pathway.Importantly,in clinical cervical cancer cases,ALOX15 is negatively associated with macrophages infiltration,which also raises the possibility that macrophages reduce ALOX15 levels in cervical cancer.Moreover,both univariate and multivariate Cox analyses show ALOX15 expression is independent prognostic factor and positively associated with good prognosis in cervical cancer.Altogether,this study reveals the potential utility of targeting TAMs in ferroptosis-based treatment and ALOX15 as prognosis indicators for cervical cancer.
基金supported by the National Key R&D Program of China No.2022YFE03150200the Institute of Energy,Hefei Comprehensive National Science Center(Grant No.21KZS207)+2 种基金National Natural Science Foundation of China(No.52077212)the Youth Innovation Promotion Association of CAS(Grant No.2021444)Hundred-Talent Program,Chinese Academy of Sciences.
文摘In order to utilize high‐temperature superconducting Yttrium Barium Copper Oxide(YBCO)tapes to develop superconducting cables for high magnet field applications,it is critical to ensure the stable operation of the YBCO cable under challenging mechanical and thermal conditions.A new type of cable featuring the winding of YBCO and copper tapes around a spiral stainless steel tube has been proposed to increase flexibility and cooling.Experiments are performed to confirm that its critical current varies with the bending diameter.The cables wound with nine YBCO tapes in three layers show a critical current degradation of less than 5%for a bending diameter of 30 mm.The performance of the cable degrades as the number of wound layers increases.The critical current degradation of cable specimens wound from 15 tapes in five layers reached approximately 12%for a bending diameter of 30 mm.In addition,when compared to traditional CORC cable specimens,the developed cable specimens show better‐bending flexibility and achieve a lower critical bending diameter.The finite element models show that the higher elasticity coefficient and lower plasticity of the stainless steel spiral tube results in a lower strain on the YBCO tapes of the HFRC cable than that of the CORC cable,and the maximum strain on the YBCO tapes of the HFRC cable was only about 10%of that of the CORC cable.Therefore,it is less likely that the YBCO tape in this type of cable will reach the irreversible strain limit during bending,resulting in a degradation in current carrying performance.Furthermore,the cooling efficiency can be improved by flowing the cooling medium inside the central core,which can significantly improve its thermal stability.These advantages indicate the possibility of using it in future high‐field magnets with high current carrying capacity at fields greater than 15 T.
基金Supported by Natural Science Foundation of Hunan Province of China(2019JJ50119)Educational Commission of Hunan Province of China(18C0510)Zhuzhou City Science and Technology Plan(Zhu Ke Fa[2017]No.68)。
文摘A power-transmission collection line is connected to each wind turbine of a wind farm and then connected to the incoming switchgear at the low-voltage side of the booster station at a certain distance.Therefore,the grouping of the wind turbines in the wind farm determines the layout of the lines and affects the line impedance.The line structure and composition of the wind farm are analyzed,and the relationship between the impedance of the collection line and reactive power generated by the wind turbine at low-voltage ride through is derived.We conclude that the smaller the equivalent impedance of the wind farm collection line structure is,the greater the reactive power at the wind farm collection line point is.In addition,the economic aspect of the collection line needs to be considered in the design.The economic aspect and impedance values have contrasting characteristics.Therefore,according to the condition of minimum impedance and optimized economic aspect,an optimization model of a wind-farm collector-circuit structure is proposed.The optimal structure of the wind farm collector circuit is calculated using the Monte Carlo method,and the theoretical analysis is verified by simulation.
基金supported by the Strategic Priority Research Program of Chinese Academy of Science under Grant No.XDB25000000Comprehensive Research Facility for Fusion Technology Program of China under Contract No.2018-000052-73-01-001228+2 种基金the National Nature Science Foundation of China(No.52077212)the Youth Innovation Promotion Association,Chinese Academy of ScienceChina Scholarship Council.
文摘High Temperature Superconductor(HTS)materials can operate at higher magnetic fields up to 20 T with high critical current and higher operating temperature,compared to low temperature superconductors(LTS).A Highly Flexible REBCO Cable(HFRC)is introduced at the Institute of Plasma Physics,Chinese Academy of Sciences(ASIPP);a cabling method that is suitable for REBCO HTS tape having anisotropic material properties in its thin REBCO layer.This type of HTS superconducting cable shows high potential for applications in nuclear fusion.The alternating currents and magnetic fields in tokamak type of fusion magnets,cause AC power losses in such cables,which can provoke instability of the conductor by induced currents and increase the temperature.As a first step in characterizing the electromagnetic(EM)performance of an HFRC cable,the AC loss and contact resistance of the HFRC prototype cable were measured at the University of Twente.The measurements were done in liquid helium(4.2 K)with AC magnetic fields,applied perpendicular to the cable's long axis.The AC loss was measured simultaneously by a calibrated gas flow calorimeter utilizing the helium boil-off method,and by the magnetization method using pick-up coils.For the applied test conditions,no coupling loss could be distinguished as a part of the overall AC loss.It is suggested that this might be explained by the shielding of the conductor interior from the applied magnetic field by the outer tape layer due to the high critical current density of the REBCO tape,leading to a high penetration field.
文摘The publication of The Tat'ping Heavenly Chronicle (Taiping tianr) in 1862 marks a critical moment in the development of the Taiping propaganda machine. Printed with copper plate printing technology that evinces imperial authority, this text is the only official history written by the Taipings in their quest to institute an overarching narrative of the movement. A systematic description of the origin and nature of the Taiping movement, The Taiping Heavenly Chronicle aims to establish Hong Xiuquan as the sole religious and political leader after the internecine Tianjing Incident (1856), which radically restructured the Taiping leadership. Using imagery, popular literary tropes, and narrative devices, this text incorporates the heterogeneous elements found in the Christian-inspired Taiping discourse to rewrite thousands of years of Chinese history.
基金supported by the National Key R&D Program of China(No.2022YFE03150200)the Strategic Priority Research Program of Chinese Academy of Science under Grant No.XDB25000000+2 种基金Comprehensive Research Facility for Fusion Technology Program of China under Contract No.2018‐000052‐73‐01‐001228the National Nature Science Foundation of China(No.52077212)the Youth Innovation Promotion Association,Chinese Academy of Science(Grant No.2021444).
文摘Due to the high current capability and excellent flexibility,High Flexible REBCO Cables(HFRC)have emerged as an important candidate for composite high‐temperature superconducting conductors.The REBCO six around one Cable‐In‐Conduit Conductor(CICC)concept has been designed for application in the Central Solenoid(CS)coil of the China Fusion Engineering Test Reactor.In the application of fusion devices,the performance of CICC under electromagnetic(EM)loading and thermal stress is very important for reliable and economic operation.Therefore,a 1.22 m long sub‐cable with HFRC design for CICC was manufactured and tested at 4.2 K in a background magnetic field up to 5.8 T.The aim is to investigate the stability of the current‐carrying properties of the HFRC cable under electromagnetic and thermal cyclic loading.The test results show that the critical current(I_(c))of the HFRC cable reached 17.3 kA in a background magnetic field of 5.8 T at 4.2 K.Furthermore,no performance degradation was observed after 24 cycles of 80 kN/m peak load with a background field of 5.8 T and 8 warm‐up‐cool‐down cycles between 77 K and room temperature.The test results provide a good basis for the development of full‐size conductors in future magnet applications.