Nano-Au-decorated hierarchical porous cobalt sulfide derived from ZIF-67 toward optimized oxygen evolution catalysis:Important roles of microstructures and electronic modulation

Enhancing both the number of active sites available and the intrinsic activity of Co-based electrocatalysts simultaneously is a desirable goal.Herein,a ZIF-67-derived hierarchical porous cobalt sulfide decorated by Au nanoparticles(NPs)(denoted as HP-Au@CoxSy@ZIF-67)hybrid is synthesized by low-temperature sulfuration treatment.The well-defined macroporous-mesoporous-microporous structure is obtained based on the combination of polystyrene spheres,as-formed CoxSy nanosheets,and ZIF-67 frameworks.This novel three-dimensional hierarchical structure significantly enlarges the three-phase interfaces,accelerating the mass transfer and exposing the active centers for oxygen evolution reaction.The electronic structure of Co is modulated by Au through charge transfer,and a series of experiments,together with theoretical analysis,is performed to ascertain the electronic modulation of Co by Au.Meanwhile,HP-Au@CoxSy@ZIF-67 catalysts with different amounts of Au were synthesized,wherein Au and NaBH4 reductant result in an interesting“competition effect”to regulate the relative ratio of Co^(2+)/Co^(3+),and moderate Au assists the electrochemical performance to reach the highest value.Consequently,the optimized HP-Au@CoxSy@ZIF-67 exhibits a low overpotential of 340 mV at 10 mA cm^(-2)and a Tafel slope of 42 mV dec-1 for OER in 0.1 M aqueous KOH,enabling efficient water splitting and Zn-air battery performance.The work here highlights the pivotal roles of both microstructural and electronic modulation in enhancing electrocatalytic activity and presents a feasible strategy for designing and optimizing advanced electrocatalysts.

血液-血管耦合特性与脉搏波传播特性的关系

脉搏波既不可简单地理解为可压缩血液流体中的压力纵波,也不可简单地理解为沿固体血管传播的涨缩位移横波,而是超乎普通想象的流-固耦合和纵波-横波耦合的复杂波。从分析耦合本构关系的新途径出发,本文中提出了一个流-固耦合/纵波-横波耦合的串联模型,可为解读"位数形势"中医脉诊提供更丰富的信息。结果表明,脉搏波耦合系统的等效体积压缩模量Ks以及相应的耦合系统脉搏波传播速度cs主要依赖于两个无量纲参数:血液-血管模量比Kb(p)/E(p)和薄壁血管径厚比D(p)/h0,它们因人而异、因人的不同脉搏位置而异。文中定量分析了它们对cs的影响,显示人体的Kb/E值在103数量级,从而cs值在100~101m/s数量级,以适应人体生理生化反应。由临床有创测量,证实脉搏体积横波与脉搏压力纵波是相耦合地以相同速度传播;还显示脉搏波是在其波阵面上具有氧合生化反应的"生物波"。此外,还讨论了"脉压放大"现象与非线性本构关系和与血管分叉处加载增强反射之间的关系,并讨论了Lewis关于重搏波形成的假设。

脉搏波本构关系实验研究的探索

脉搏波本构关系决定着脉搏波的传播特征。如何通过实验研究来确定脉搏波本构关系,以及如何通过这些方法从现有文献数据来获得脉搏波本构关系,是当前研究的核心之一。本文中探索了3个可行途径:(1)由实测脉搏波波速对压力的关系C(p)进行反分析(无创法);(2)直接对脉搏波p-V本构关系进行实测(有创法);(3)由一系列实测脉搏波波形进行Lagrange反分析(无创法)。采用上述方法,根据现有文献数据,发现由C(p)关系的Rogers-Huang简化式可推得指数型p(V)本构关系;由MK-Hughes式可推得对数型p(V)本构关系。脉搏波传播特性随非线性本构参数发生显著变化。按中医体质分类观点,相应的脉搏波本构关系原则上也有不同类型,因人而定。在这个意义上,脉搏波的Lagrange反分析具有广阔发展前景,但它对正确选择测点和提高测量敏感性和精度等方面提出了更高要求。

预应力简支梁固有频率研究

基于经典轴压模型,研究了预应力筋偏心距、预应力大小对简支梁固有频率的影响,对已有的简支梁固有频率理论计算公式进一步修正.以预应力混凝土简支梁为例,通过ANSYS有限元分析了预应力筋偏心距以及预应力改变对预应力简支梁固有频率的影响,验证了混凝土模拟单元与预应力筋模拟单元的2种联系方式对计算结果没有影响,以期望为以后的预应力混凝土梁设计及健康检测提供参考.

论心脏功能的“泵说”与“波说”

分析了心脏功能的“泵说”和“波说”。研究表明,心脏扮演的角色实际上不是泵,而是脉搏波发生器,产生一系列携带能量的脉搏波。每个脉搏波由升支和降支组成。前者对应于加载过程:压力、粒子速度、能量和血氧饱和度均随时间升高。而后者则对应于卸载过程:压力、粒子速度、能量以及血氧饱和度都下降,直至为零。因此,“泵说”中诸如Windkessel效应、一机二泵和舒张泵等概念都难以成立。所谓约1.5 W的心脏功率实质上表征了每个脉搏波的功率。针对脉搏波是流-固耦合和纵波-横波耦合的复杂波之特征,研究表明,能量的主要部分(99.99%)由横波携带,它沿固体血管传播,损耗低,效率高。研究还表明,血管分支处广义波阻抗的增大有助于抵消脉搏波传播中的衰减耗散,升高传入血管分支的脉搏波脉压,可视为人体的一种自我调节机制。

Influence of aluminium nitride as a foaming agent on the preparation of foam glass-ceramics from high-titanium blast furnace slag

To effectively reuse high-titanium blast furnace slag （TS）, foam glass-ceramics were successfully prepared by powder sintering at 1000℃. TS and waste glass were used as the main raw materials, aluminium nitride （AIN） as the foaming agent, and borax as the fluxing agent. The influence of the amount of A1N added （lwt%-5wt%） on the crystalline phases, microstructure, and properties of the produced foam glass-ceramics was studied. The results showed that the main crystal phases were perovskite, diopside, and augite. With increasing A1N content, a transformation from diopside to augite occurred and the crystallinity of the pyroxene phases slightly decreased. Initially, the aver- age pore size and porosity of the foam glass-ceramics increased and subsequently decreased; similarly, their bulk density and compressive strength decreased and subsequently increased. The optimal properties were obtained when the foam glass-ceramics were prepared by adding 4wt% AIN.

Kindergartens Reopening in the Period of Regular Epidemic Prevention and Control, Benefitial or Harmful?

In the period of regular epidemic prevention and control of coronavirus disease 2019(COVID-19)in our country,work resumption has been fully advanced.But there are still new sporadic local cases and imported cases across the country.In this situation,whether kindergartens reopening will increase the risk of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spread still remains uncertain.We reviewed two pediatric patients with moderate COVID-19,collected the epidemiologic information and monitored the cycle threshold value of rectal specimen and the viral loads,and discussed the transmission of SARS-CoV-2 in pediatric patients and the virulence of feces in children with moderate COVID-19,in order to analyze the risk of kindergartens reopening.

Numerical Simulation of Concrete Plate Damaged Under Explosive Loading

The grisliness after-effects can be induced by explosion accident with the collapsing of the structures, the demolishing of the equipments and the casualty of the human beings. Isolation belt constructed between the blast point and the construction is one of the useful design schemes for blast resistance. The nonlinear procedure ANSYS/LSDYNA970 is used to simulate the contact detonation and the isolation belt of blast resistance filled with the air or water respectively. The results indicate that the maximal damage can be caused by the contact detonation, and the isolation belt of blast resistent filled with water can reduce the damage greatly.

Clinical study of docetaxel-vinorelbine as second-line chemotherapy in advanced non-small cell lung cancer

Objective： To evaluate the efficacy and toxicity of docetaxel and vinorelbine as second-line chemotherapy in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods： 48 histologically or cytologically confirmed NSCLC patients with progressive or recurrent disease after first-line treatment were treated with docetaxel and vinoretbine. The chemotherapy included vinorelbine （25 mg/m^2） on days 1,5 and docetaxel （60 mg/m^2） on day 1. The treatment was repeated every 3 weeks. Patients receiving at least two cycles were evaluated for efficacy and toxicity. Results： Of 48 patients, 1 patient achieved complete response and 16 achieved partial response. Overall response rate for all 48 patients was 35.4% （17/48）. Main hematologic toxicities included neutropenia （60.4%） and febrile neutropenia （29.2%） and non-hematologic toxicities were mild. Conclusion： The combination of docetaxel-vinorelbine as second-line chemotherapy is an effective regimen with manageable toxicity for the treatment of advanced NSCLC. Further studies may confirm these results.

Genetic architecture and key genes controlling the diversity of oil composition in rice grains

Rice grain oil is a valuable nutrient source.However,the genetic basis of oil biosynthesis in rice grains remains unclear.In this study,we performed a genome-wide association study on oil composition and oil concentration in a diverse panel of 533 cultivated rice accessions.High variation for 11 oil-related traits was observed,and the oil composition of rice grains showed differentiation among the subpopulations.We identified 46 loci that are significantly associated with grain oil concentration or composition,16 of which were detected in three recombinant inbred line populations.Twenty-six candidate genes encoding enzymes involved in oil metabolism were identified from these 46 loci,four of which(PAL6,LIN6,MYR2,and ARA6)were found to contribute to natural variation in oil composition and to show differentiation among the subpopulations.Interestingly,population genetic analyses revealed that specific haplotypes of PAL6 and LIN6 have been selected in japonica rice.Based on these results,we propose a possible oil biosynthetic pathway in rice grains.Collectively,our results provide new insights into the genetic basis of oil biosynthesis in rice grains and can facilitate marker-based breeding of rice varieties with enhanced oil and grain quality.

Insight into role of Ni/Fe existing forms in reversible oxygen catalysis based on Ni-Fe single-atom/nanoparticles and N-doped carbon

Oxygen catalysis reactions play essential roles in metal-air batteries,fuel cells,water electrolysis and artificial photosynthesis,with their development receiving significant attention in recent years.Understanding the structure-activity relationship plays an important role in the construction and performance optimization of reversible oxygen catalyst.

Therapeutic effects of EGF-modified curcumin/ chitosan nano-spray on wound healing

Dermal injury,including trauma,surgical incisions,and burns,remain the most prevalent socio-economical health care issue in the clinic.Nanomedicine represents a reliable administration strategy that can promote the healing of skin lesions,but the lack of effective drug delivery methods can limit its effectiveness.In this study,we developed a novel nano-drug delivery system to treat skin defects through spraying.We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor(EGF)to develop an aqueous EGF-modified spray(EGF@CCN)for the treatment of dermal wounds.In vitro assays showed that the EGF@CCN displayed low cytotoxicity,and that curcumin was continuously and slowly released from the EGF@CCN.In vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats,showing that the EGF@CCN had significant advantages in promoting wound healing.On day 12 post-operation,skin defects in the rats of the EGF@CCN group were almost completely restored.These effects were related to the activity of curcumin and EGF on skin healing,and the high compatibility of the nano formulation.We therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.

A novel aptasensor strategy for protein detection based on G-quadruplex and exonuclease Ⅲ-aided recycling amplification

The detection of biomarkers is of great significance in the diagnosis of numerous diseases,especially cancer.Herein,we developed a sensitive and universal fluorescent aptasensor strategy based on magnetic beads,DNA G-quadruplex,and exonuclease Ⅲ(Exo Ⅲ).In the presence of a target protein,a label-free single strand DNA(ssDNA)hybridized with the aptamer was released as a trigger DNA due to specific recognition between the aptamer and target.Subsequently,ssDNA initiates the ExoⅢ-aided recycling to amplify the fluorescence signal,which was caused by N-methylmesoporphyrin IX(NMM)insertion into the G-quadruplex structure.This proposed strategy combines the excellent specificity between the aptamer and target,high sensitivity of the fluorescence signal by G-quadruplex and ExoⅢ-aided recycling amplification.We selected(50-1200 nmol/L)MUC1,a common tumor biomarker,as the proof-of-concept target to test the specificity of our aptasenso r.Results reveal that the sensor sensitively and selectively detected the target protein with limits of detection(LODs)of 3.68 and 12.83 nmol/L in buffer solution and 10%serum system,respectively.The strategy can be easily applied to other targets by simply substituting corresponding aptamers and has great potential in the diagnosis and monitoring of several diseases.

Number estimation of controllers for pinning a complex dynamical network

Number estimation of controllers is a fundamental question in pinning synchronization of complex networks. This paper studies the problem of controller number in synchronizing a complex network of coupled dynamical systems by means of pinning. For a complex network with a symmetric coupling matrix and full coupling between the nodes, we formulate network synchronization via pinning as a linear matrix inequality criterion, and provide a lower bound and an upper bound of the controller number for a given complex network with fixed architecture. Several numerical examples with Barabási-Albert network topologies are provided to verify our theoretical results.