Introduction: Endovascular treatment is an effective treatment for large vessel occlusive ischemic stroke. The number of Stent Retriever passes is an important link in the strategy of endovascular treatment, and is cl...Introduction: Endovascular treatment is an effective treatment for large vessel occlusive ischemic stroke. The number of Stent Retriever passes is an important link in the strategy of endovascular treatment, and is closely related to the clinical outcome and prognosis of patients with acute ischemic stroke, but there is still a lack of unified understanding. In order to provide reference for clinical practice and related research, this paper reviewed the recent important literatures. Methods: We searched PubMed, Embase, and Cochrane databases, using the terms “stents”, “stroke” and “thrombectomy”. Priority was given to human studies. Only English language papers were accepted. Analyze the articles by title and abstract. Results: The number of Stent Retriever passes is closely related to the rate of recanalization, hemorrhagic transformation, recanalization time, surgical procedures and clinical prognosis. Along with the increase of the number of Stent Retriever passes, the vascular recanculation rate decreased successively, in turn, reduced the rate of blood vessels, 3 times may be the target vascular occlusion which should try the best of times, ≥4 times may not improve the opportunity of recanalization and not conducive to the prognosis, at the same time, increase the risk of HT and related complications occurred. Conclusion: It is necessary to avoid unplanned, additional attempts at EVT. The number of Stent Retriever passes has significant effects on the outcome of EVT of AIS in many aspects. How to better personalized EVT strategy is the focus of future research.展开更多
BACKGROUND As of June 1,2020,over 370000 coronavirus disease 2019(COVID-19)deaths have been reported to the World Health Organization.However,the risk factors for patients with moderate-to-severe or severe-to-critical...BACKGROUND As of June 1,2020,over 370000 coronavirus disease 2019(COVID-19)deaths have been reported to the World Health Organization.However,the risk factors for patients with moderate-to-severe or severe-to-critical COVID-19 remain unclear.AIM To explore the characteristics and predictive markers of severely and critically ill patients with COVID-19.METHODS A retrospective study was conducted at the B11 Zhongfaxincheng campus and E1-3 Guanggu campus of Tongji Hospital affiliated with Huazhong University of Science and Technology in Wuhan.Patients with COVID-19 admitted from 1st February 2020 to 8th March 2020 were enrolled and categorized into 3 groups:The moderate group,severe group and critically ill group.Epidemiological data,demographic data,clinical symptoms and outcomes,complications,laboratory tests and radiographic examinations were collected retrospectively from the hospital information system and then compared between groups.RESULTS A total of 126 patients were enrolled.There were 59 in the moderate group,49 in the severe group,and 18 in the critically ill group.Multivariate logistic regression analysis showed that age[odd ratio(OR)=1.055,95%(confidence interval)CI:1.099-1.104],elevated neutrophil-to-lymphocyte ratios(OR=4.019,95%CI:1.045-15.467)and elevated high-sensitivity cardiac troponin I(OR=10.126,95%CI:1.088-94.247)were high-risk factors.CONCLUSION The following indicators can help clinicians identify patients with severe COVID-19 at an early stage:age,an elevated neutrophil-to-lymphocyte ratio and high sensitivity cardiac troponin I.展开更多
The removal of phosphate from wastewater using traditional biological or precipitation methods is a huge challenge.The use of high-performance adsorbents has been shown to address this problem.In this study,a novel co...The removal of phosphate from wastewater using traditional biological or precipitation methods is a huge challenge.The use of high-performance adsorbents has been shown to address this problem.In this study,a novel composite adsorbent,composed of dolomite-doped biochar and bentonite(DO/BB),was first synthesized via co-pyrolysis.The combination of initial phosphate concentration of 100 mg/L and 1.6 g/L of DO/BB exhibited a high phosphate-adsorption capacity of 62 mg/g with a removal efficiency of 99.8%.It was also stable in complex water environments with various levels of solution pH,coexisting anions,high salinity,and humic acid.With this new composite,the phosphate concentration of the actual domestic sewage decreased from 9 mg/L to less than 1 mg/L,and the total nitrogen and chemical oxygen demand also decreased effectively.Further,the cross-flow treatment using a PVC membrane loaded with DO/BB(PVC-DO/BB),decreased the phosphate concentration from 1 to 0.08 mg/L,suggesting outstanding separation of phosphate pollutants via a combination of adsorption and separation.In addition,the removal of phosphate by the PVC-DO/BB membrane using NaOH solution as an eluent was almost 90%after 5 cycles.The kinetic,isotherm and XPS analysis before and after adsorption suggested that adsorption via a combination of electrostatic interaction,complexation and precipitation contributed to the excellent separation by the as-obtained membranes.展开更多
Enhanced phosphorus treatment and recovery has been continuously pursued due to the stringent wastewater discharge regulations and a phosphate supply shortage. Here, a new adsorption-membrane separation strategy was d...Enhanced phosphorus treatment and recovery has been continuously pursued due to the stringent wastewater discharge regulations and a phosphate supply shortage. Here, a new adsorption-membrane separation strategy was developed for rational reutilization of phosphate from sea cucumber aquaculture wastewater using a Zr-modified-bentonite filled polyvinyl chloride membrane. The as-obtained polyvinyl chloride/Zr-modified-bentonite membrane was highly permeability (940 L/(m2·h)), 1–2 times higher than those reported in other studies, and its adsorption capacity was high (20.6 mg/g) when the phosphate concentration in water was low (5 mg/L). It remained stable under various conditions, such as different pH, initial phosphate concentrations, and the presence of different ions after 24 h of adsorption in a cross-flow filtration system. The total phosphorus and phosphate removal rate reached 91.5% and 95.9%, respectively, after the membrane was used to treat sea cucumber aquaculture wastewater for 24 h and no other water quality parameters had been changed. After the purification process, the utilization of the membrane as a new source of phosphorus in the phosphorus-free f/2 medium experiments indicated the high cultivability of economic microalgae Phaeodactylum tricornutum FACHB-863 and 1.2 times more chlorophyll a was present than in f/2 medium. The biomass and lipid content of the microalgae in the two different media were similar. The innovative polyvinyl chloride/Zr-modified-bentonite membrane used for phosphorus removal and recovery is an important instrument to establish the groundwork for both the treatment of low concentration phosphate from wastewater as well as the reuse of enriched phosphorus in required fields.展开更多
To the Editor: Frailty is defined as a vulnerable state that places older adults at increased risk for adverse health outcomes, and can explain substantial heterogeneity of health status. Previous studies have demonst...To the Editor: Frailty is defined as a vulnerable state that places older adults at increased risk for adverse health outcomes, and can explain substantial heterogeneity of health status. Previous studies have demonstrated the utility of the frailty phenotype scale and frailty index (FI) in identifying frail older people in China.[1] Several experimental and clinical studies on frailty have been published using the above methods in recent years, but influential factors for discriminating frailty levels in Chinese older adults have not yet been determined. Elucidating this issue is of importance, because early detection of frailty-related factors and subsequent intervention are essential for safeguarding functionality and preventing the occurrence of adverse consequences among older people.展开更多
文摘Introduction: Endovascular treatment is an effective treatment for large vessel occlusive ischemic stroke. The number of Stent Retriever passes is an important link in the strategy of endovascular treatment, and is closely related to the clinical outcome and prognosis of patients with acute ischemic stroke, but there is still a lack of unified understanding. In order to provide reference for clinical practice and related research, this paper reviewed the recent important literatures. Methods: We searched PubMed, Embase, and Cochrane databases, using the terms “stents”, “stroke” and “thrombectomy”. Priority was given to human studies. Only English language papers were accepted. Analyze the articles by title and abstract. Results: The number of Stent Retriever passes is closely related to the rate of recanalization, hemorrhagic transformation, recanalization time, surgical procedures and clinical prognosis. Along with the increase of the number of Stent Retriever passes, the vascular recanculation rate decreased successively, in turn, reduced the rate of blood vessels, 3 times may be the target vascular occlusion which should try the best of times, ≥4 times may not improve the opportunity of recanalization and not conducive to the prognosis, at the same time, increase the risk of HT and related complications occurred. Conclusion: It is necessary to avoid unplanned, additional attempts at EVT. The number of Stent Retriever passes has significant effects on the outcome of EVT of AIS in many aspects. How to better personalized EVT strategy is the focus of future research.
基金Supported by Disciplines Construction Project of Peking Union Medical College,No.201920202102.
文摘BACKGROUND As of June 1,2020,over 370000 coronavirus disease 2019(COVID-19)deaths have been reported to the World Health Organization.However,the risk factors for patients with moderate-to-severe or severe-to-critical COVID-19 remain unclear.AIM To explore the characteristics and predictive markers of severely and critically ill patients with COVID-19.METHODS A retrospective study was conducted at the B11 Zhongfaxincheng campus and E1-3 Guanggu campus of Tongji Hospital affiliated with Huazhong University of Science and Technology in Wuhan.Patients with COVID-19 admitted from 1st February 2020 to 8th March 2020 were enrolled and categorized into 3 groups:The moderate group,severe group and critically ill group.Epidemiological data,demographic data,clinical symptoms and outcomes,complications,laboratory tests and radiographic examinations were collected retrospectively from the hospital information system and then compared between groups.RESULTS A total of 126 patients were enrolled.There were 59 in the moderate group,49 in the severe group,and 18 in the critically ill group.Multivariate logistic regression analysis showed that age[odd ratio(OR)=1.055,95%(confidence interval)CI:1.099-1.104],elevated neutrophil-to-lymphocyte ratios(OR=4.019,95%CI:1.045-15.467)and elevated high-sensitivity cardiac troponin I(OR=10.126,95%CI:1.088-94.247)were high-risk factors.CONCLUSION The following indicators can help clinicians identify patients with severe COVID-19 at an early stage:age,an elevated neutrophil-to-lymphocyte ratio and high sensitivity cardiac troponin I.
基金The authors would like to acknowledge the National Natural Science Foundation of China(No.52078189)the Key R&D Program of Jiangsu Province(China)(No.BE2020024)for supporting this research.
文摘The removal of phosphate from wastewater using traditional biological or precipitation methods is a huge challenge.The use of high-performance adsorbents has been shown to address this problem.In this study,a novel composite adsorbent,composed of dolomite-doped biochar and bentonite(DO/BB),was first synthesized via co-pyrolysis.The combination of initial phosphate concentration of 100 mg/L and 1.6 g/L of DO/BB exhibited a high phosphate-adsorption capacity of 62 mg/g with a removal efficiency of 99.8%.It was also stable in complex water environments with various levels of solution pH,coexisting anions,high salinity,and humic acid.With this new composite,the phosphate concentration of the actual domestic sewage decreased from 9 mg/L to less than 1 mg/L,and the total nitrogen and chemical oxygen demand also decreased effectively.Further,the cross-flow treatment using a PVC membrane loaded with DO/BB(PVC-DO/BB),decreased the phosphate concentration from 1 to 0.08 mg/L,suggesting outstanding separation of phosphate pollutants via a combination of adsorption and separation.In addition,the removal of phosphate by the PVC-DO/BB membrane using NaOH solution as an eluent was almost 90%after 5 cycles.The kinetic,isotherm and XPS analysis before and after adsorption suggested that adsorption via a combination of electrostatic interaction,complexation and precipitation contributed to the excellent separation by the as-obtained membranes.
基金This work was successively financed by the Jiangsu Innovation Center of Marine Bioresources(China)(No.822153216).
文摘Enhanced phosphorus treatment and recovery has been continuously pursued due to the stringent wastewater discharge regulations and a phosphate supply shortage. Here, a new adsorption-membrane separation strategy was developed for rational reutilization of phosphate from sea cucumber aquaculture wastewater using a Zr-modified-bentonite filled polyvinyl chloride membrane. The as-obtained polyvinyl chloride/Zr-modified-bentonite membrane was highly permeability (940 L/(m2·h)), 1–2 times higher than those reported in other studies, and its adsorption capacity was high (20.6 mg/g) when the phosphate concentration in water was low (5 mg/L). It remained stable under various conditions, such as different pH, initial phosphate concentrations, and the presence of different ions after 24 h of adsorption in a cross-flow filtration system. The total phosphorus and phosphate removal rate reached 91.5% and 95.9%, respectively, after the membrane was used to treat sea cucumber aquaculture wastewater for 24 h and no other water quality parameters had been changed. After the purification process, the utilization of the membrane as a new source of phosphorus in the phosphorus-free f/2 medium experiments indicated the high cultivability of economic microalgae Phaeodactylum tricornutum FACHB-863 and 1.2 times more chlorophyll a was present than in f/2 medium. The biomass and lipid content of the microalgae in the two different media were similar. The innovative polyvinyl chloride/Zr-modified-bentonite membrane used for phosphorus removal and recovery is an important instrument to establish the groundwork for both the treatment of low concentration phosphate from wastewater as well as the reuse of enriched phosphorus in required fields.
文摘To the Editor: Frailty is defined as a vulnerable state that places older adults at increased risk for adverse health outcomes, and can explain substantial heterogeneity of health status. Previous studies have demonstrated the utility of the frailty phenotype scale and frailty index (FI) in identifying frail older people in China.[1] Several experimental and clinical studies on frailty have been published using the above methods in recent years, but influential factors for discriminating frailty levels in Chinese older adults have not yet been determined. Elucidating this issue is of importance, because early detection of frailty-related factors and subsequent intervention are essential for safeguarding functionality and preventing the occurrence of adverse consequences among older people.
