Oxaliplatin is the common chemotherapy drug for the treatment of colorectal cancer(CRC),however,the harmful Fusobacterium nucleatum(Fn)that existed in the CRC tumor tissues leads to extreme drug resistance to oxalipla...Oxaliplatin is the common chemotherapy drug for the treatment of colorectal cancer(CRC),however,the harmful Fusobacterium nucleatum(Fn)that existed in the CRC tumor tissues leads to extreme drug resistance to oxaliplatin,which reduces the anticancer efficiency.Here we fabricated a new dendrimer-based nanocomplex with anti-tumor and antibacterial dual-functions through conjugating Pt(Ⅳ)-complex and lauric acid(LA)to the dendritic carrier PAMAM(G=3).The synthesized PAMAM-Pt-LA nanoparticle was further coated with hyaluronic acid(HA)on its surface through electrostatically interaction in order to enhance biocompatibility and tumor targeting.The biocompatibility,anti-tumor activity and antibacterial activity of PAMAM-Pt-LA@HA nanocomplex were evaluated in vitro.The results showed that the PAMAM-Pt-LA@HA nanocomplex ehxibited a good biocompatibility,high anti-colorectal cancer activity and high anti-Fn activity.This dual-functional nanocomplex provides a new method to develop anticancer nanomedicines that will be more therapeutically efficacious and less toxic than oxaliplatin for the treatment of CRC.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.22075209,U20A20260 and 52103180)a distinguished professor of Tianjin,the Leading Talents Program of the Tianjin Educational Committee+2 种基金the Key program of Tianjin Municipal Natural Science Foundation(Nos.18JCZDJC37700 and 18JCQNJC72300)the Training Project of Innovation Team of Colleges and Universities in Tianjin(No.TD13-5020)the Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid(No.KTRDHA-Z201901)for the financial support。
文摘Oxaliplatin is the common chemotherapy drug for the treatment of colorectal cancer(CRC),however,the harmful Fusobacterium nucleatum(Fn)that existed in the CRC tumor tissues leads to extreme drug resistance to oxaliplatin,which reduces the anticancer efficiency.Here we fabricated a new dendrimer-based nanocomplex with anti-tumor and antibacterial dual-functions through conjugating Pt(Ⅳ)-complex and lauric acid(LA)to the dendritic carrier PAMAM(G=3).The synthesized PAMAM-Pt-LA nanoparticle was further coated with hyaluronic acid(HA)on its surface through electrostatically interaction in order to enhance biocompatibility and tumor targeting.The biocompatibility,anti-tumor activity and antibacterial activity of PAMAM-Pt-LA@HA nanocomplex were evaluated in vitro.The results showed that the PAMAM-Pt-LA@HA nanocomplex ehxibited a good biocompatibility,high anti-colorectal cancer activity and high anti-Fn activity.This dual-functional nanocomplex provides a new method to develop anticancer nanomedicines that will be more therapeutically efficacious and less toxic than oxaliplatin for the treatment of CRC.
