基于HS-SPME-GC/MS的丁香与肉桂复配前后物质变化分析

以方剂“丁桂散”为依据,探究丁香、肉桂复配前后挥发性物质的变化.研究采用顶空-固相微萃取-气相色谱/质谱联用技术,结合统计学方法对丁香、肉桂及复配物的挥发性物质进行比较分析.从丁香、肉桂及复配物中分别鉴定出60种,55种,61种挥发性化学成分;共有的挥发性成分有31种,分别占其总量的444.84‰、666.63‰、505.51‰.存在于丁香、肉桂中的13种、10种挥发性成分未在复配物中检出,复配后挥发性物质的种类上没有变化,但复配物的挥发性物质含量占比,相较于复配前的单个原料发生了显著的变化.不同复配比例下“丁桂散”的欧式距离相似度存在线性关系y=-0.375x+0.423,R^(2)=0.993,且丁香对复配后挥发性物质的影响占主导地位.

Effect of Combining Acupuncture and Functional Training on Post-stroke Functional Impairment of Hand

Objective:To observe the clinical effect of combining acupuncture and functional training on post-stroke functional impairment of hand.Methods:A total of 165 cases who met the inclusion criteria were randomized into a treatment group(85 cases)and a control group(80cases).Cases in the treatment group were treated with routine acupuncture points plus Shixuan(EX-UE 11)and Xiaohai(SI 8),whereas cases in the control group were treated with routine acupuncture points alone.After acupuncture,cases in both groups conducted functional training in upper limbs.The finger grip strength and hand function were assessed before and after 3-course treatment.Results:Cases in the treatment group obtained better finger grip strength and hand function than those in the control group(both P<0.05).Conclusion:In addition to functional training,adding Shixuan(EX-UE 11)and Xiaohai(SI 8)to traditional acupuncture formulae works better for post-stroke functional impairment of hand.

家庭个性化强制性运动疗法对社区脑卒中患者的影响

目的:观察在家庭环境下使用个性化的强制性运动疗法对社区脑卒中患者的康复疗效。方法:将2018年1月~2019年12月收集的75例社区脑卒中患者,按随机数字表法分为治疗组38例、对照组37例。治疗组采用家庭个性化强制性运动疗法治疗(3h/天,5天/周,持续12周),对照组采用家庭常规康复锻炼,比较两组干预前后改良Barthel指数(MBI)、简化Fugl-Meyer运动功能评分(FMA)、功能综合评定量表(FCA)评分,干预结束后12周随访。结果:干预12周后,两组MBI、FMA及FCA评分较治疗前均有提高(P<0.05),且治疗组优于对照组(P<0.05);12周后随访时,治疗组MBI、FAC评分有持续提高(P<0.05),对照组变化差异无统计学意义(P>0.05),两组FMA评分变化差异无统计学意义(P>0.05)。结论:家庭个性化强制性运动疗法对社区脑卒中患者的运动功能、日常生活活动能力及综合功能有明显疗效,并有很好的延后效应,可作为适宜技术在脑卒中社区及家庭康复中推广应用。