Glaucoma is a multifactorial optic neuropathy progressive characterized by structural loss of retinal ganglion cells(RGCs)and irreversible loss of vision.High intraocular pressure(HIOP)is a high risk factor for glauco...Glaucoma is a multifactorial optic neuropathy progressive characterized by structural loss of retinal ganglion cells(RGCs)and irreversible loss of vision.High intraocular pressure(HIOP)is a high risk factor for glaucoma.It has been reported that the manners of RGCs'loss are in-depth explored after acute HIOP injury,such as,apoptosis,autophagy and necrosis.However,pyroptosis,a novel type of pro-inflammatory cell programmed necrosis,rarely reported after HIOP injury.Researches also showed that melatonin possessing substantial anti-inflammatory properties.However,whether melatonin could alleviate retinal neurons death,especially pyroptosis,by HIOP injury is unclear.This study explored pyroptosis of retinal neurons and the effects of melatonin preventing retinal neurons form pyroptosis after acute HIOP injury.Establish acute HIOP model in rat by increasing the IOP and then reperfusion.展开更多
Modern anatomy research requires human specimen obtained from biobank.Promoting public sample donation will help the construction of the biobank,which further promote related medical research.In the first part,600 que...Modern anatomy research requires human specimen obtained from biobank.Promoting public sample donation will help the construction of the biobank,which further promote related medical research.In the first part,600 questionnaires(include 20 questions)with simple promotion material were distributed to respondent.In the second part,1800 questionnaires with same questions were disseminated through three different way:600 questionnaires with picture-based promotional material attached,600 questionnaires with word-based promotional material,600 questionnaires were completed after a biobank related lecture.All the participants were asked twice before and after correspond publicity education.展开更多
Osteoporosis(OP)is a metabolic bone disease characterized by decreased bone mass,reduced bone density,and destruction of bone microstructures,which resulting in an increased brittleness and susceptibility to fractures...Osteoporosis(OP)is a metabolic bone disease characterized by decreased bone mass,reduced bone density,and destruction of bone microstructures,which resulting in an increased brittleness and susceptibility to fractures.The incidence of osteoporosis is associated with aging and some genetical and physiology abnormalities.With the accelerated growth of aged population in China,a large group of population has reduced bone density.The mid-aged and senior people are highly susceptible to osteoporosis.While some young people who have irregular dietary schedule and unhealthy life style might cause increased rate of osteoporosis.Signal transducers and activators of transcription 3(STAT3)is a transcription factor ubiquitously expressed in somatic and stem cells such as tumor cells,mesenchymal stem cells,osteoblasts,osteoclasts and osteocytes.STAT3 is involved in the regulation of cell proliferation differentiation,apoptosis,and other physiological functions.The results of relevant animal experiments and clinical trials showed that abnormal expression of STAT3 would affect normal bone development.展开更多
Macrophages are an important component of innate and adaptive immunity in liver that they play important roles in maintaining homeostasis,resisting pathogen invasion and activating the immune system.However,many studi...Macrophages are an important component of innate and adaptive immunity in liver that they play important roles in maintaining homeostasis,resisting pathogen invasion and activating the immune system.However,many studies have proved that tumor associated macrophages(TAMs)promoted the malignant progression of hepatocellular carcinoma(HCC).Associated regulatory mechanisms of TAMs phenotype in tumor microenvironment(TME)are still not fully understood.展开更多
Modern medical researches require standard bio-sample acquired from structured biobank.The mechanism of Intel-biobank data-sharing,which is vital in modern biobank construction,have not been established in China.This ...Modern medical researches require standard bio-sample acquired from structured biobank.The mechanism of Intel-biobank data-sharing,which is vital in modern biobank construction,have not been established in China.This survey was conducted using questionnaires and interview,which mainly focused on the following aspects of intel-biobank data-sharing:present situation,informed consent,additional authorization and expected adverse consequences.The research object of this study was directed to 114 staff members or managers from 34 facilities.We found that 13 biobankers form 10 facilities said they had been achieved data sharing between different biobank,39 biobankers from 9 facilities indicated that they were planning data sharing,62 from the rest 15 facilities have not planned inter-biobank data sharing yet.展开更多
In addition to the lens,tumors can oceur in almost all tissues of the eye.Lacking of effective biomarkers makes diagnosis of ocular tumors difficult.Biobanks are important resources for biomarker discovery and assay d...In addition to the lens,tumors can oceur in almost all tissues of the eye.Lacking of effective biomarkers makes diagnosis of ocular tumors difficult.Biobanks are important resources for biomarker discovery and assay development.To support the validation of novel biomarkers and assays,we established a biobank to collect body fluids and tissue and associate data from subjects with ocular tumor diseases.A standard operating procedure of collection,transportation,processing and preservation of human samples according to the experience of biobanks domestic and foreign have been established.Associated data had been collected and statistical analysis of the existing data had been performed.Cooperation between the eye tumor biobank and the Department of Ophthalmology,Xiangya Hospital,Central South University has been established,and various samples can be obtained.Currently,708 samples are available from 78 subjects with 11 types of benign tumors and 12 types of malignant tumors,including hemangioma,schwannoma,retinoblastoma,lymphoma,basal cell carcinoma,melanoma,sarcomas,ect.展开更多
Osteosarcoma(OS)is one of the most difficult cancers to treat due to its resistance to chemotherapy.The essential role played by Mel-l in promoting chemoresistance has been observed in a variety of cancers,including O...Osteosarcoma(OS)is one of the most difficult cancers to treat due to its resistance to chemotherapy.The essential role played by Mel-l in promoting chemoresistance has been observed in a variety of cancers,including OS,while the underlying mechanism remains unclear.We investigated the expression of Mcl-1 in 42 paired OS specimens obtained before and after adjuvant chemotherapy,and its correlation with clinicopathological characteristics.Loss and gain of function studies were performed to analyze the effects of Mcl-1 modulations on the chemosensitivity,and the mechanism involved in the deregulation of Mcl-1 in OS cells.展开更多
文摘Glaucoma is a multifactorial optic neuropathy progressive characterized by structural loss of retinal ganglion cells(RGCs)and irreversible loss of vision.High intraocular pressure(HIOP)is a high risk factor for glaucoma.It has been reported that the manners of RGCs'loss are in-depth explored after acute HIOP injury,such as,apoptosis,autophagy and necrosis.However,pyroptosis,a novel type of pro-inflammatory cell programmed necrosis,rarely reported after HIOP injury.Researches also showed that melatonin possessing substantial anti-inflammatory properties.However,whether melatonin could alleviate retinal neurons death,especially pyroptosis,by HIOP injury is unclear.This study explored pyroptosis of retinal neurons and the effects of melatonin preventing retinal neurons form pyroptosis after acute HIOP injury.Establish acute HIOP model in rat by increasing the IOP and then reperfusion.
文摘Modern anatomy research requires human specimen obtained from biobank.Promoting public sample donation will help the construction of the biobank,which further promote related medical research.In the first part,600 questionnaires(include 20 questions)with simple promotion material were distributed to respondent.In the second part,1800 questionnaires with same questions were disseminated through three different way:600 questionnaires with picture-based promotional material attached,600 questionnaires with word-based promotional material,600 questionnaires were completed after a biobank related lecture.All the participants were asked twice before and after correspond publicity education.
文摘Osteoporosis(OP)is a metabolic bone disease characterized by decreased bone mass,reduced bone density,and destruction of bone microstructures,which resulting in an increased brittleness and susceptibility to fractures.The incidence of osteoporosis is associated with aging and some genetical and physiology abnormalities.With the accelerated growth of aged population in China,a large group of population has reduced bone density.The mid-aged and senior people are highly susceptible to osteoporosis.While some young people who have irregular dietary schedule and unhealthy life style might cause increased rate of osteoporosis.Signal transducers and activators of transcription 3(STAT3)is a transcription factor ubiquitously expressed in somatic and stem cells such as tumor cells,mesenchymal stem cells,osteoblasts,osteoclasts and osteocytes.STAT3 is involved in the regulation of cell proliferation differentiation,apoptosis,and other physiological functions.The results of relevant animal experiments and clinical trials showed that abnormal expression of STAT3 would affect normal bone development.
文摘Macrophages are an important component of innate and adaptive immunity in liver that they play important roles in maintaining homeostasis,resisting pathogen invasion and activating the immune system.However,many studies have proved that tumor associated macrophages(TAMs)promoted the malignant progression of hepatocellular carcinoma(HCC).Associated regulatory mechanisms of TAMs phenotype in tumor microenvironment(TME)are still not fully understood.
文摘Modern medical researches require standard bio-sample acquired from structured biobank.The mechanism of Intel-biobank data-sharing,which is vital in modern biobank construction,have not been established in China.This survey was conducted using questionnaires and interview,which mainly focused on the following aspects of intel-biobank data-sharing:present situation,informed consent,additional authorization and expected adverse consequences.The research object of this study was directed to 114 staff members or managers from 34 facilities.We found that 13 biobankers form 10 facilities said they had been achieved data sharing between different biobank,39 biobankers from 9 facilities indicated that they were planning data sharing,62 from the rest 15 facilities have not planned inter-biobank data sharing yet.
文摘In addition to the lens,tumors can oceur in almost all tissues of the eye.Lacking of effective biomarkers makes diagnosis of ocular tumors difficult.Biobanks are important resources for biomarker discovery and assay development.To support the validation of novel biomarkers and assays,we established a biobank to collect body fluids and tissue and associate data from subjects with ocular tumor diseases.A standard operating procedure of collection,transportation,processing and preservation of human samples according to the experience of biobanks domestic and foreign have been established.Associated data had been collected and statistical analysis of the existing data had been performed.Cooperation between the eye tumor biobank and the Department of Ophthalmology,Xiangya Hospital,Central South University has been established,and various samples can be obtained.Currently,708 samples are available from 78 subjects with 11 types of benign tumors and 12 types of malignant tumors,including hemangioma,schwannoma,retinoblastoma,lymphoma,basal cell carcinoma,melanoma,sarcomas,ect.
文摘Osteosarcoma(OS)is one of the most difficult cancers to treat due to its resistance to chemotherapy.The essential role played by Mel-l in promoting chemoresistance has been observed in a variety of cancers,including OS,while the underlying mechanism remains unclear.We investigated the expression of Mcl-1 in 42 paired OS specimens obtained before and after adjuvant chemotherapy,and its correlation with clinicopathological characteristics.Loss and gain of function studies were performed to analyze the effects of Mcl-1 modulations on the chemosensitivity,and the mechanism involved in the deregulation of Mcl-1 in OS cells.
