BACKGROUND The relation between orthodontic treatment and temporomandibular disorders(TMDs)is under debate;the management of TMD during orthodontic treatment has always been a challenge.If TMD symptoms occur during or...BACKGROUND The relation between orthodontic treatment and temporomandibular disorders(TMDs)is under debate;the management of TMD during orthodontic treatment has always been a challenge.If TMD symptoms occur during orthodontic treatment,an immediate pause of orthodontic adjustments is recommended;the treatment can resume when the symptoms are managed and stabilized.CASE SUMMARY This case report presents a patient(26-year-old,female)with angle class I,skeletal class II and TMDs.The treatment was a hybrid of clear aligners,fixed appliances and temporary anchorage devices(TADs).After 3 mo resting and treatment on her TMD,the patient’s TMD symptom alleviated,but her anterior occlusion displayed deep overbite.Therefore,the fixed appliances with TAD were used to correct the anterior deep-bite and level maxillary and mandibular deep curves.After the levelling,the patient showed dual bite with centric relation and maximum intercuspation discrepancy on her occlusion.After careful examination of temporomandibular joints(TMJ)position,the stable bite splint and Invisible Mandibular Advancement appliance were used to reconstruct her occlusion.Eventually,the improved facial appearance and relatively stable occlusion were achieved.The 1-year follow-up records showed there was no obvious change in TMJ morphology,and her occlusion was stable.CONCLUSION TMD screening and monitoring is of great clinical importance in the TMD susceptible patients.Hybrid treatment with clear aligners and fixed appliances and TADs is an effective treatment modality for the complex cases.展开更多
The development of technologies such as big data and blockchain has brought convenience to life,but at the same time,privacy and security issues are becoming more and more prominent.The K-anonymity algorithm is an eff...The development of technologies such as big data and blockchain has brought convenience to life,but at the same time,privacy and security issues are becoming more and more prominent.The K-anonymity algorithm is an effective and low computational complexity privacy-preserving algorithm that can safeguard users’privacy by anonymizing big data.However,the algorithm currently suffers from the problem of focusing only on improving user privacy while ignoring data availability.In addition,ignoring the impact of quasi-identified attributes on sensitive attributes causes the usability of the processed data on statistical analysis to be reduced.Based on this,we propose a new K-anonymity algorithm to solve the privacy security problem in the context of big data,while guaranteeing improved data usability.Specifically,we construct a new information loss function based on the information quantity theory.Considering that different quasi-identification attributes have different impacts on sensitive attributes,we set weights for each quasi-identification attribute when designing the information loss function.In addition,to reduce information loss,we improve K-anonymity in two ways.First,we make the loss of information smaller than in the original table while guaranteeing privacy based on common artificial intelligence algorithms,i.e.,greedy algorithm and 2-means clustering algorithm.In addition,we improve the 2-means clustering algorithm by designing a mean-center method to select the initial center of mass.Meanwhile,we design the K-anonymity algorithm of this scheme based on the constructed information loss function,the improved 2-means clustering algorithm,and the greedy algorithm,which reduces the information loss.Finally,we experimentally demonstrate the effectiveness of the algorithm in improving the effect of 2-means clustering and reducing information loss.展开更多
目的探讨基于组织学、免疫组化的三阴型乳腺癌(triple-negative breast cancer,TNBC)分型标准,为完善TNBC分型治疗提供理论依据。方法根据组织学特点和免疫组化标志物AR、CD8、FOXC1的表达对TNBC进行分型,比较TNBC亚型的临床病理特征、...目的探讨基于组织学、免疫组化的三阴型乳腺癌(triple-negative breast cancer,TNBC)分型标准,为完善TNBC分型治疗提供理论依据。方法根据组织学特点和免疫组化标志物AR、CD8、FOXC1的表达对TNBC进行分型,比较TNBC亚型的临床病理特征、预后差异。结果93例TNBC中腔面雄激素受体型23例(24.7%),免疫调节型24例(25.8%),基底样免疫抑制型39例(42.0%),间充质型7例(7.5%)。TNBC亚型的临床病理特征:pT分期(P=0.030)、组织学分级(P<0.001)、肿瘤间质淋巴细胞浸润模式(P<0.001)、PD-L1(P<0.001)、HER2低表达(P=0.024)差异均有统计学意义;各亚型间的无瘤生存率差异无统计学意义(P>0.05)。单因素分层生存分析:亚型间pT1分期的无瘤生存率差异有统计学意义(P=0.011),其余临床病理特征均为非独立预后因素。结论TNBC基于组织学、免疫组化分型的临床病理特征有差异,有望替代复杂基因表达谱分型,为TNBC分型和靶向治疗提供理论依据。展开更多
为量化灾害链应急能力评估中灾害间的链式传递效应,通过叠加(折减)效应系数量化灾害间的链式传递关系,基于灾害链之间的转换概率、阈值,推导灾害链应急能力评价模型和计算方法。综合考虑应急准备能力和响应恢复能力双维度指标,构建暴雨...为量化灾害链应急能力评估中灾害间的链式传递效应,通过叠加(折减)效应系数量化灾害间的链式传递关系,基于灾害链之间的转换概率、阈值,推导灾害链应急能力评价模型和计算方法。综合考虑应急准备能力和响应恢复能力双维度指标,构建暴雨-滑坡灾害链应急能力评估指标体系。运用熵权法、逼近理想排序法(technique for order preference by similarity to an ideal solution,TOPSIS)计算暴雨和滑坡2种单一灾种的应急能力指数,结合灾害链应急能力评价模型计算得到暴雨-滑坡灾害链应急能力,以粤港澳大湾区典型暴雨-滑坡灾害链为例展开实证分析。研究结果表明:粤港澳大湾区中部地区暴雨-滑坡灾害链应急能力与滑坡单一灾害的应急能力相比呈下降趋势,东部地区整体呈上升趋势,西北部地区和西南部地区暴雨-滑坡灾害链应急能力与滑坡单一灾害的应急能力基本保持一致。最终得到的暴雨-滑坡灾害链应急能力评估结果更加科学合理,可为暴雨-滑坡灾害链应急能力评估与提升提供技术支撑。展开更多
基金Natural Science Foundation of Jiangsu Province, No. SBK2021021787the Major Project of the Health Commission ofJiangsu Province, No. ZD2022025and the Key Project of the Nanjing Health Commission, No. ZKX20048.
文摘BACKGROUND The relation between orthodontic treatment and temporomandibular disorders(TMDs)is under debate;the management of TMD during orthodontic treatment has always been a challenge.If TMD symptoms occur during orthodontic treatment,an immediate pause of orthodontic adjustments is recommended;the treatment can resume when the symptoms are managed and stabilized.CASE SUMMARY This case report presents a patient(26-year-old,female)with angle class I,skeletal class II and TMDs.The treatment was a hybrid of clear aligners,fixed appliances and temporary anchorage devices(TADs).After 3 mo resting and treatment on her TMD,the patient’s TMD symptom alleviated,but her anterior occlusion displayed deep overbite.Therefore,the fixed appliances with TAD were used to correct the anterior deep-bite and level maxillary and mandibular deep curves.After the levelling,the patient showed dual bite with centric relation and maximum intercuspation discrepancy on her occlusion.After careful examination of temporomandibular joints(TMJ)position,the stable bite splint and Invisible Mandibular Advancement appliance were used to reconstruct her occlusion.Eventually,the improved facial appearance and relatively stable occlusion were achieved.The 1-year follow-up records showed there was no obvious change in TMJ morphology,and her occlusion was stable.CONCLUSION TMD screening and monitoring is of great clinical importance in the TMD susceptible patients.Hybrid treatment with clear aligners and fixed appliances and TADs is an effective treatment modality for the complex cases.
基金Foundation of National Natural Science Foundation of China(62202118)Scientific and Technological Research Projects from Guizhou Education Department([2023]003)+1 种基金Guizhou Provincial Department of Science and Technology Hundred Levels of Innovative Talents Project(GCC[2023]018)Top Technology Talent Project from Guizhou Education Department([2022]073).
文摘The development of technologies such as big data and blockchain has brought convenience to life,but at the same time,privacy and security issues are becoming more and more prominent.The K-anonymity algorithm is an effective and low computational complexity privacy-preserving algorithm that can safeguard users’privacy by anonymizing big data.However,the algorithm currently suffers from the problem of focusing only on improving user privacy while ignoring data availability.In addition,ignoring the impact of quasi-identified attributes on sensitive attributes causes the usability of the processed data on statistical analysis to be reduced.Based on this,we propose a new K-anonymity algorithm to solve the privacy security problem in the context of big data,while guaranteeing improved data usability.Specifically,we construct a new information loss function based on the information quantity theory.Considering that different quasi-identification attributes have different impacts on sensitive attributes,we set weights for each quasi-identification attribute when designing the information loss function.In addition,to reduce information loss,we improve K-anonymity in two ways.First,we make the loss of information smaller than in the original table while guaranteeing privacy based on common artificial intelligence algorithms,i.e.,greedy algorithm and 2-means clustering algorithm.In addition,we improve the 2-means clustering algorithm by designing a mean-center method to select the initial center of mass.Meanwhile,we design the K-anonymity algorithm of this scheme based on the constructed information loss function,the improved 2-means clustering algorithm,and the greedy algorithm,which reduces the information loss.Finally,we experimentally demonstrate the effectiveness of the algorithm in improving the effect of 2-means clustering and reducing information loss.
文摘目的探讨基于组织学、免疫组化的三阴型乳腺癌(triple-negative breast cancer,TNBC)分型标准,为完善TNBC分型治疗提供理论依据。方法根据组织学特点和免疫组化标志物AR、CD8、FOXC1的表达对TNBC进行分型,比较TNBC亚型的临床病理特征、预后差异。结果93例TNBC中腔面雄激素受体型23例(24.7%),免疫调节型24例(25.8%),基底样免疫抑制型39例(42.0%),间充质型7例(7.5%)。TNBC亚型的临床病理特征:pT分期(P=0.030)、组织学分级(P<0.001)、肿瘤间质淋巴细胞浸润模式(P<0.001)、PD-L1(P<0.001)、HER2低表达(P=0.024)差异均有统计学意义;各亚型间的无瘤生存率差异无统计学意义(P>0.05)。单因素分层生存分析:亚型间pT1分期的无瘤生存率差异有统计学意义(P=0.011),其余临床病理特征均为非独立预后因素。结论TNBC基于组织学、免疫组化分型的临床病理特征有差异,有望替代复杂基因表达谱分型,为TNBC分型和靶向治疗提供理论依据。
文摘为量化灾害链应急能力评估中灾害间的链式传递效应,通过叠加(折减)效应系数量化灾害间的链式传递关系,基于灾害链之间的转换概率、阈值,推导灾害链应急能力评价模型和计算方法。综合考虑应急准备能力和响应恢复能力双维度指标,构建暴雨-滑坡灾害链应急能力评估指标体系。运用熵权法、逼近理想排序法(technique for order preference by similarity to an ideal solution,TOPSIS)计算暴雨和滑坡2种单一灾种的应急能力指数,结合灾害链应急能力评价模型计算得到暴雨-滑坡灾害链应急能力,以粤港澳大湾区典型暴雨-滑坡灾害链为例展开实证分析。研究结果表明:粤港澳大湾区中部地区暴雨-滑坡灾害链应急能力与滑坡单一灾害的应急能力相比呈下降趋势,东部地区整体呈上升趋势,西北部地区和西南部地区暴雨-滑坡灾害链应急能力与滑坡单一灾害的应急能力基本保持一致。最终得到的暴雨-滑坡灾害链应急能力评估结果更加科学合理,可为暴雨-滑坡灾害链应急能力评估与提升提供技术支撑。
