Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis

AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P【0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF.

持续气道正压通气治疗对伴有冠状动脉疾病和阻塞性睡眠呼吸暂停的非肥胖患者的血脂和高敏C反应蛋白水平的影响

阻塞性睡眠呼吸暂停（obstructive sleep apnoea,OSA）在发达国家是一个重要的公共健康问题,但在中国,大部分患者不重视该疾病。不断增长的证据显示,重度OSA同增长的心血管发病率和病死率有关。大量的关于高血压和OSA关系的研究报告已证实,OSA是高血压的重要危险因子。有效的持续气道正压通气（continuous positive airway pressure,CPAP）治疗降低了血压。很少有研究关注到非肥胖患者,仅有少数随机试验测试了CPAP治疗后对患者空腹血脂的效果。