A practical synthesis of trans-3,4-diol derivatives of substituted chromans via epoxidation with combined use of mangenese (III) salen complex 3 and hydrogen peroxide has been developed. These diol derivatives are key...A practical synthesis of trans-3,4-diol derivatives of substituted chromans via epoxidation with combined use of mangenese (III) salen complex 3 and hydrogen peroxide has been developed. These diol derivatives are key intermediates for the synthesis of a series of biologically important chroman compounds.展开更多
The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. C...The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR.展开更多
文摘A practical synthesis of trans-3,4-diol derivatives of substituted chromans via epoxidation with combined use of mangenese (III) salen complex 3 and hydrogen peroxide has been developed. These diol derivatives are key intermediates for the synthesis of a series of biologically important chroman compounds.
文摘The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR.
