variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades.However,the way by viruses target IFN-signaling extracellularly has not been discovered.Infection by both corona...variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades.However,the way by viruses target IFN-signaling extracellularly has not been discovered.Infection by both coronavirus SARS-CoV-2 and enterovirus 71(EV71 or EV-A71)can cause severe diseases such as neurological disorders and even death in children.展开更多
Stress proteins(SPs)including heat-shock proteins(HSPs),RNA chaperones,and ER associated stress proteins are molecular chaperones essential for cellular homeostasis.The major functions of HSPs include chaperoning misf...Stress proteins(SPs)including heat-shock proteins(HSPs),RNA chaperones,and ER associated stress proteins are molecular chaperones essential for cellular homeostasis.The major functions of HSPs include chaperoning misfolded or unfolded polypeptides,protecting cells from toxic stress,and presenting immune and inflammatory cytokines.Regarded as a double-edged sword,HSPs also cooperate with numerous viruses and cancer cells to promote their survival.RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins(hnRNPs),which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II.hnRNPs involve in a large number of cellular processes,including chromatin remodelling,transcription regulation,RNP assembly and stabilization,RNA export,virus replication,histonelike nucleoid structuring,and even intracellular immunity.Dysregulation of stress proteins is associated with many human diseases including human cancer,cardiovascular diseases,neurodegenerative diseases(e.g.,Parkinson’s diseases,Alzheimer disease),stroke and infectious diseases.In this review,we summarized the biologic function of stress proteins,and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections.As SPs also attract a great interest as potential antiviral targets(e.g.,COVID-19),we also discuss the present progress and challenges in this area of HSP-based drug development,as well as with compounds already under clinical evaluation.展开更多
基金The work was partially supported by grants from The Science Technology and Innovation Committee of Shenzhen Municipality[JCYJ20180507181627057]RGC General Research Fund of Hong Kong Special Administrative Region[11104020]Strategic funds from The City University of Hong Kong to M.He.
文摘variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades.However,the way by viruses target IFN-signaling extracellularly has not been discovered.Infection by both coronavirus SARS-CoV-2 and enterovirus 71(EV71 or EV-A71)can cause severe diseases such as neurological disorders and even death in children.
基金supported by grants from The Science Technology and Innovation Committee of Shenzhen Municipality[JCYJ20170818100531426,JCYJ20180507181627057]grants from National Science Foundation of China[81671995]+1 种基金the general research grant of Hong Kong[11100215]Strategic funds from City University of Hong Kong.
文摘Stress proteins(SPs)including heat-shock proteins(HSPs),RNA chaperones,and ER associated stress proteins are molecular chaperones essential for cellular homeostasis.The major functions of HSPs include chaperoning misfolded or unfolded polypeptides,protecting cells from toxic stress,and presenting immune and inflammatory cytokines.Regarded as a double-edged sword,HSPs also cooperate with numerous viruses and cancer cells to promote their survival.RNA chaperones are a group of heterogeneous nuclear ribonucleoproteins(hnRNPs),which are essential factors for manipulating both the functions and metabolisms of pre-mRNAs/hnRNAs transcribed by RNA polymerase II.hnRNPs involve in a large number of cellular processes,including chromatin remodelling,transcription regulation,RNP assembly and stabilization,RNA export,virus replication,histonelike nucleoid structuring,and even intracellular immunity.Dysregulation of stress proteins is associated with many human diseases including human cancer,cardiovascular diseases,neurodegenerative diseases(e.g.,Parkinson’s diseases,Alzheimer disease),stroke and infectious diseases.In this review,we summarized the biologic function of stress proteins,and current progress on their mechanisms related to virus reproduction and diseases caused by virus infections.As SPs also attract a great interest as potential antiviral targets(e.g.,COVID-19),we also discuss the present progress and challenges in this area of HSP-based drug development,as well as with compounds already under clinical evaluation.
