Li4-xSbxSn1-xS4 solid solutions for air-stable solid electrolytes

The sulfide solid electrolytes have the characteristics of high ionic conductivity and low grain boundary resistance, which make them suitable for bulk-type all-solid-state batteries. However, most of them suffer from poor stability in air. Here, we explore the air stable sulfide solid electrolytes in Li4-xSbxSn1-xS4 system. The solid solutions of Li4-xSbxSn1-xS4(0 ≤ x ≤ 0.5) can be formed in Li4-xSbxSn1-xS4 system. Li3.8 Sb0.2 Sn0.8 S4 achieves the highest ionic conductivity of 3.5 × 10-4 S cm-1 in this system,which is 5 times as that of Li4 Sn S4 and 3 orders of magnitude higher than that of Li3 Sb S4, respectively. Li3.8 Sb0.2 Sn0.8 S4 crystallizes into the same structure with high ionic conductivity phase of β-Li3 PS4. Moreover, Li3.8 Sb0.2 Sn0.8 S4 owns good stability in humid air. Matching with LiCoO2 and Li4 Ti5 O12,Li3.8 Sb0.2 Sn0.8 S4 exhibits the potential to be applied in all-solid-state batteries.

Na3.8[Sn0.67Si0.33]0.8Sb0.2S4:A quinary sodium fast ionic conductor for all-solid-state sodium battery

Strategy of Sb-substitution is carried out on the template structure Na4Sn0.67M0.33S4(M=Si,Ge),which affords a series of quinary sulfide-based sodium fast ionic conductors formulated as Na4-x[Sn0.67M0.33]1-xSbxS4(M=Si,x=0.1,0.2,0.3;M=Ge,x=0.2.).Among them,the highest ambient ionic conductivity(1.75×10^-4 S cm^-1)is achieved when M=Si and x=0.2.The new fast ionic conductor Na3.8[Sn0.67Si0.33]0.8Sb0.2S4 is isostructural to its structure template Na4Sn0.67Si0.33S4 and thus crystallizes in the space group of I41/acd.It is shown that the incorporation of Sb improves the ionic conductivity.The study of lattice parameters shows that the improvement of the ion conductivity by Sbsubstitution is mainly due to the enlarged crystal lattice.Furthermore,using Na3.8[Sn0.67Si0.33]0.8Sb0.2S4as solid electrolytes,room temperature all-solid-state sodium battery of Se0.05S0.95@pPAN/Na3Sn is realized,which proves the novel fast ionic conductor a potential candidate to apply in sodium solid state battery.This work not only extends the scope of Na4[Sn0.67Si0.33]S4,the I41/acd space group template,but also deepens the understanding of the lattice size effect on the structure and property relationship by aliovalent substitution.

Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization

Echinacea purpurea modulates tumor progression,but the underlying mechanism is poorly defined.We isolated and purified a novel homogeneous polysaccharide from E.purpurea(EPPA),which was shown to be an arabinogalactan with a mean molecular mass(Mr)of 3.8×10^(4)Da and withα-(1→5)-L-Arabinan as the backbone and a-L-Araf-(1→,→6)-b-D-Galp-(1→,and →4)-α-D-GalpA-(1/as the side chains.Interestingly,oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile(e.g.,facilitating M1 macrophages)in tumor micro-environment by single-cell RNA sequencing(scRNA-seq)analysis.

Systemic delivery of microRNA for treatment of brain ischemia

Brain ischemia is the second leading cause of death and the third leading cause of disability in the world.Systemic delivery of microRNA,a class of molecules that regulate the expression of cellular proteins associated with angiogenesis,cell growth,proliferation and differentiation,holds great promise for the treatment of brain ischemia.However,their therapeutic efficacy has been hampered by poor delivery efficiency of microRNA.We report herein a platform technology based on microRNA nanocapsules,which enables their effective delivery to the disease sites in the brain.Exemplified by microRNA-21,intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume,neurological deficit and histopathological severity.

Synthesis of acridinones via palladium-catalyzed reductive annulation of 2-nitrobenzaldehydes and resorcinols

The catalytic conversion of biomass-derived feedstocks into functional molecules is of significance to synthetic organic chemistry.Herein,through a palladium-catalyzed reductive annulation reaction of resorcinols and 2-nitrobenzaldehydes,we present a new approach for the direct synthesis of acridinone derivatives,featuring operational simplicity,good substrate compatibility,and readily available feedstocks.