Effects of Denervation on the Mid-term Results of Knee Joint Functions after Non-resurfaced Total Knee Arthroplasty

Objective:Total knee arthroplasty(TKA)has become an effective treatment modality for end-stage osteoarthritis and rheumatoid arthritis.Postoperative problems such as anterior knee pain affect postoperative patient satisfaction.Patellar denervation has been proposed as a technique to relieve pain,but its efficacy remains controversial.This study evaluated the mid-and long-term effects of patellar denervation on postoperative knee joint functions,hoping to provide better guidance for clinical practice.Methods:This study is a prospective randomized controlled double-blind study.58 patients undergoing bilateral non-resurfaced total knee arthroplasty were included and randomized into two groups.Both groups underwent total knee arthroplasty while patellar denervation was performed only on the experimental group.Information regarding whether if patellar denervation was performed were withheld from all patients and outcome assessors.All surgeries were performed by the same high-level professional physician,and the post-stable knee prosthesis system(PS Scorpio NRG PS,Stryker)was used during the surgeries.The knee joint functions were evaluated by professional assessors before and after surgery.The evaluation indicators mainly include KSS scoring,Western Ontario and McMaster Universities(WOMAC)scoring and Visual Analogue Scale(VAS),FJS scoring,etc.The follow-up period was 3 years and 5 years after surgery.Results:The experimental group had better KSS and FJS scores than the control group,the difference was statistically significant.There was no significant inter-group difference in WOMAC and VAS scores.Conclusion:The patellar denervation in TKA patients has positive effects on the mid-and long-term recovery of knee joint functions,and the postoperative satisfaction is better.

Equilibrium folding and unfolding dynamics to reveal detailed free energy landscape of src SH3 protein by magnetic tweezers

Src SH3 protein domain is a typical two-state protein which has been confirmed by research of denaturant-induced unfolding dynamics.Force spectroscopy experiments by optical tweezers and atomic force microscopy have measured the force-dependent unfolding rates with different kinds of pulling geometry.However,the equilibrium folding and unfolding dynamics at constant forces has not been reported.Here,using stable magnetic tweezers,we performed equilibrium folding and unfolding dynamic measurement and force-jump measurement of src SH3 domain with tethering points at its N-and C-termini.From the obtained force-dependent transition rates,a detailed two-state free energy landscape of src SH3 protein is constructed with quantitative information of folding free energy,transition state barrier height and position,which exemplifies the capability of magnetic tweezers to study protein folding and unfolding dynamics.

Synthesis and characterization of a novel collector for the desulfurization of fine high-sulfur bauxite via reverse flotation

Bauxite is one of the main raw materials in the alumina industry.Fine high-sulfur bauxite flotation desulfurization is a great challenge presently.This study aims to synthesize nanoparticle collectors(NPCs)by emulsion polymerization to improve the abovesaid flotation desulfurization process.The physicochemical properties of high-sulfur bauxite were analyzed,and the experimental conditions for the synthesis of NPCs were optimized.The interaction mechanism between NPCs and pyrite was studied via fundamental analyses including SEM(Scanning Electron Microscope),FT-IR(Fourier Transform Infrared spectoscopy),Zeta-potential,XPS(X-ray Photoelectron Spectroscopy),and wettability.Under the closed-circuit flotation flowsheet of"one roughing-two cleaning-three scavenging",aluminum concen-trate with a yield of 85.91%and sulfur content of 0.56%were obtained using a common collector.However,with the addition of the novel NPC,aluminum concentrate with a yield of 85.70%and sulfur content of 0.36%could be obtained by a simpler flowsheet of"one roughing-one cleaning-two scav-enging".The improvement in flotation performance is suggested to be contributed by the addition of spherical NPC,which induced a rougher and more hydrophobic pyrite surface.

Chemically engineered dendrite growth of uniform monolayers MoS_(2) for enhanced photoluminescence[Invited]

Large area and uniform monolayer MoS_(2)is of great importance for optoelectronic devices but is commonly suffering from rather weak photoluminescence.Here,by engineering the concentration profiles of gaseous chemicals through extra trace amounts of water,we demonstrate the uniform dendrite-type growth of monolayer MoS_(2)unraveled by spatially resolved fluorescence spectroscopy,which exhibits macroscopic monolayer flakes [up to centimeter scale] with photoluminescence intensity of orders of magnitude higher than conventional chemical vapor deposition monolayer MoS_(2).Both spectroscopic evidence and theoretical models reveal that the fast-fractal dendrite growth can be ascribed to the extra introduced water sources that generate sufficient aqueous gas around the S-poor regions nearby the central-axis zone,leading to highly efficient Mo sources transport,accelerated S atom corrosion nearby grain edges,and/or defect sites,as well as enhanced photoemission intensity.Our results may provide new insight for high throughput fabrication of MoS_(2)monolayers with high yield photoluminescence efficiency.