The new generation of world information technology revolution has promoted the vigorous development and rapid transform of the new economy.The in-depth implementation of a series of Chinese important national strategi...The new generation of world information technology revolution has promoted the vigorous development and rapid transform of the new economy.The in-depth implementation of a series of Chinese important national strategies such as“Made in China 2025”and“Internet+”is urgently needed the support of innovative and outstanding emerging engineering talents with cross-border integration abilities.Therefore,interdisciplinary education plays an important role in the training of the needed emerging engineering talents.Taking cybersecurity as an example,this paper summarizes the professional’s requirements and proposes the educational objectives of Harbin Institute of Technology.Then the objective oriented curriculum system and the teaching model emphasizing project-based learning are introduced.The practice and effect of interdisciplinary education are discussed and analyzed in four aspects including curriculum system,faculty,students and academy education.Finally,suggestions are made on the individualized education and sustainable competitiveness cultivation of the emerging engineering talents.展开更多
Background:Hemispherectomy is an efective treatment option for patients with drug-resistant epilepsy caused by hemispheric lesions.However,patients often have deterioration of their motor functions postoperatively.Dif...Background:Hemispherectomy is an efective treatment option for patients with drug-resistant epilepsy caused by hemispheric lesions.However,patients often have deterioration of their motor functions postoperatively.Difusion spectrum imaging(DSI)was reliable in presenting the natural shape of the white matter fbers.At the same time,the natural sprawl pyramid tract(PT)might be more intuitive for predicting postoperative motor functions.Therefore,we assessed the motor functions by the natural shape revealed by DSI tractography.Methods:Ten children with drug-resistant epilepsy who were candidates for hemispherectomy performed DSI PTs tractography and transcranial magnetic stimulation(TMS)for motor mapping.The motor function was evaluated with muscle strength and hand grasping capability.Pyramidal tract(PT)structural integrity and TMS mapping results were compared between patients who remained stable and those with deteriorated motor functions.Receiver operating characteristic(ROC)curves with PTs asymmetric ratio were analyzed to evaluate DSI tractography diagnostic value.Results:All patients underwent DSI acquisition,while four patients successfully performed TMS.One patient had no response to TMS until the maximal machine output was reached.Four patients failed to perform TMS due to lacking cooperation.One patient was contraindicated to TMS.DSI successfully reconstructed the sharp angle fan-shaped PTs within the hemisphere.The accurate fber distribution with fber termination and thickness within the lesioned hemisphere was replicated with DSI tractography.No signifcance was found in patients’age,sex,seizure frequency,or medication between patients with stable or deteriorated postoperative motor functions.DSI efectively predicted postoperative motor function as stable with damaged PTs,mild deterioration with atrophied PTs,and intact PTs with contralateral innervation confrmed by intracranial stimulation.The area under the curve(AUC)of DSI tractography was 0.84.According to ROC,the cut-of value of PTs asymmetric ratio was 11.5%with 100%sensitivity and 75%specifcity.The sensitivity and specifcity of TMS were 2/3 and 1/2,respectively.Conclusions:The anatomic integrity of PTs with DSI tractography could efectively predict postoperative motor function after hemispherectomy.This enables neurosurgeons to inform patients and relatives about postoperative motor functions with direct morphological evidence of PTs to help them with their surgical decisions.展开更多
基金supported in part by the Ministry of Education of the People’s Republic of China under the Emerging Engineering Education Research and Practice Projects of”Research and Practice on the Cooperative Education Model of Industry-Academic Cooperation in the Emerging Engineering Education System of Chinese Universities”and“Exploration and Practice of Engineering Talent Education Model with Multidisciplinary Integration”and under Grant 18JDGC014,and by the Shandong Provincial Department of Education under Grant M2018B336.
文摘The new generation of world information technology revolution has promoted the vigorous development and rapid transform of the new economy.The in-depth implementation of a series of Chinese important national strategies such as“Made in China 2025”and“Internet+”is urgently needed the support of innovative and outstanding emerging engineering talents with cross-border integration abilities.Therefore,interdisciplinary education plays an important role in the training of the needed emerging engineering talents.Taking cybersecurity as an example,this paper summarizes the professional’s requirements and proposes the educational objectives of Harbin Institute of Technology.Then the objective oriented curriculum system and the teaching model emphasizing project-based learning are introduced.The practice and effect of interdisciplinary education are discussed and analyzed in four aspects including curriculum system,faculty,students and academy education.Finally,suggestions are made on the individualized education and sustainable competitiveness cultivation of the emerging engineering talents.
基金This work was supported by the National Natural Science Foundation of China(81871009,81801288)the National Key R&D Program of China(2016YFC0103909)the Translational and Application Project of Braininspired and Network Neuroscience on Brain Disorders,Beijing Municipal Health Commission(11000022T000000444685).
文摘Background:Hemispherectomy is an efective treatment option for patients with drug-resistant epilepsy caused by hemispheric lesions.However,patients often have deterioration of their motor functions postoperatively.Difusion spectrum imaging(DSI)was reliable in presenting the natural shape of the white matter fbers.At the same time,the natural sprawl pyramid tract(PT)might be more intuitive for predicting postoperative motor functions.Therefore,we assessed the motor functions by the natural shape revealed by DSI tractography.Methods:Ten children with drug-resistant epilepsy who were candidates for hemispherectomy performed DSI PTs tractography and transcranial magnetic stimulation(TMS)for motor mapping.The motor function was evaluated with muscle strength and hand grasping capability.Pyramidal tract(PT)structural integrity and TMS mapping results were compared between patients who remained stable and those with deteriorated motor functions.Receiver operating characteristic(ROC)curves with PTs asymmetric ratio were analyzed to evaluate DSI tractography diagnostic value.Results:All patients underwent DSI acquisition,while four patients successfully performed TMS.One patient had no response to TMS until the maximal machine output was reached.Four patients failed to perform TMS due to lacking cooperation.One patient was contraindicated to TMS.DSI successfully reconstructed the sharp angle fan-shaped PTs within the hemisphere.The accurate fber distribution with fber termination and thickness within the lesioned hemisphere was replicated with DSI tractography.No signifcance was found in patients’age,sex,seizure frequency,or medication between patients with stable or deteriorated postoperative motor functions.DSI efectively predicted postoperative motor function as stable with damaged PTs,mild deterioration with atrophied PTs,and intact PTs with contralateral innervation confrmed by intracranial stimulation.The area under the curve(AUC)of DSI tractography was 0.84.According to ROC,the cut-of value of PTs asymmetric ratio was 11.5%with 100%sensitivity and 75%specifcity.The sensitivity and specifcity of TMS were 2/3 and 1/2,respectively.Conclusions:The anatomic integrity of PTs with DSI tractography could efectively predict postoperative motor function after hemispherectomy.This enables neurosurgeons to inform patients and relatives about postoperative motor functions with direct morphological evidence of PTs to help them with their surgical decisions.