Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo ...Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo et al.,2010)or aberrant silencing of a single imprinted gene cluster(Liu et al.,2010;Stadtfeld et al.,2010),which affects their developmental and differentiation potentials.展开更多
Embryonic stem (ES) cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling cascades.
基金supported in part by grants from the Chinese Academy of Sciences(KSCX2-YW-R-110,KSCX2-YW-R-229,XDA01010403 to J.L.,KSCX1-YW-02,KJCX2-YW-M15 to J.W.)the Ministry of Science and Technology(2007CB947101,2009CB941101 to J.L.,2006CB503900,2010CB912102 to J.W.)+1 种基金the National Natural Science Foundation of China(30871430 to J.L.,30821065 to J.W.)the Shanghai Municipal Commission for Science and Technology(07DZ22919,08DJ1400502,09PJ1410900 to J.L.,07dz05907 to J.W.).
文摘Dear Editor,Recent studies show that induced pluripotent stem cells(iPSCs)generated through ectopic expression of transcription factors retain an epigenetic memory of their original somatic cells(Kim et al.,2010;Polo et al.,2010)or aberrant silencing of a single imprinted gene cluster(Liu et al.,2010;Stadtfeld et al.,2010),which affects their developmental and differentiation potentials.
文摘Embryonic stem (ES) cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling cascades.
