Dear Editor,Ten-eleven translocation(Tet)enzymes play important roles in DNA demethylation involved in various biological processes including stem cell pluripotency and differentiation,and tumorigenesis(Dawlaty et al....Dear Editor,Ten-eleven translocation(Tet)enzymes play important roles in DNA demethylation involved in various biological processes including stem cell pluripotency and differentiation,and tumorigenesis(Dawlaty et al.,2013;Wu and Zhang,2017).Tet2 deficiency or mutation leads to severe hematopoietic defects or myeloid malignancies in mice(Delhommeau et al.,2009;Ko et al.,2010;Moran-Crusio et al.,2011).Restoration of TET2 blocks aberrant self-renewal and leukemia progression in patients possessing TET2 mutations(Cimmino et al.,2017).展开更多
基金the National Natural Science Foundation of China(Grant Nos.31571546 and 91749129).
文摘Dear Editor,Ten-eleven translocation(Tet)enzymes play important roles in DNA demethylation involved in various biological processes including stem cell pluripotency and differentiation,and tumorigenesis(Dawlaty et al.,2013;Wu and Zhang,2017).Tet2 deficiency or mutation leads to severe hematopoietic defects or myeloid malignancies in mice(Delhommeau et al.,2009;Ko et al.,2010;Moran-Crusio et al.,2011).Restoration of TET2 blocks aberrant self-renewal and leukemia progression in patients possessing TET2 mutations(Cimmino et al.,2017).
