Multiple myeloma(MM)is a hematologic malignancy in which plasma cells proliferate in the bone marrow,leading to osteolytic bone destruction.Bone involvement is present in up to 90%of patients with MM and is associated...Multiple myeloma(MM)is a hematologic malignancy in which plasma cells proliferate in the bone marrow,leading to osteolytic bone destruction.Bone involvement is present in up to 90%of patients with MM and is associated with pain and skeletal-related complications,such as pathologic vertebral compression fractures(VCFs).^([1])MM-associated VCFs cause spinal instability,back pain,spinal kyphosis,neurologic dysfunction,and subsequent respiratory complications,which markedly decrease the quality of life of affected patients.展开更多
基金supported by a grant from the Capital Health Research and Development of Special(No.2020-2-5091).
文摘Multiple myeloma(MM)is a hematologic malignancy in which plasma cells proliferate in the bone marrow,leading to osteolytic bone destruction.Bone involvement is present in up to 90%of patients with MM and is associated with pain and skeletal-related complications,such as pathologic vertebral compression fractures(VCFs).^([1])MM-associated VCFs cause spinal instability,back pain,spinal kyphosis,neurologic dysfunction,and subsequent respiratory complications,which markedly decrease the quality of life of affected patients.