AIM:To demonstrate the value of Diosmin(flavonidic fraction)in the management of post-haemorhoidectomic symptoms.METHODS:Eighty-six consecutive patients with grades ⅢandⅣacute mixed hemorrhoids admitted to the Anore...AIM:To demonstrate the value of Diosmin(flavonidic fraction)in the management of post-haemorhoidectomic symptoms.METHODS:Eighty-six consecutive patients with grades ⅢandⅣacute mixed hemorrhoids admitted to the Anorectal Surgical Department of First Affiliated Hospital,Xinjiang Medical University from April 2009 to April 2010,were enrolled in this study.An observerblinded,randomized trial was conducted to compare post-haemorhoidectomic symptoms with use of Diosmin flavonidic fraction vs placebo.Eighty-six patients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk(n=43)or placebo(n=43).The Milligan-Morgan open haemorrhoidectomy was performed by a standardized diathermy excision method.Pain,bleeding,heaviness,pruritus,wound edema and mucosal discharge were observed after surgery.The postoperative symptoms and hospitalization time were recorded.RESULTS:The mean age of the Diosmin group and controls was 53.2 and 51.3 years,respectively.In Diosmin group,haemorrhoid piles were of the third degree in 33 patients and the fourth degree in 10;and in the control group,29 were of the third degree and 14 were of the fourth degree.There was no statistically significance in age,gender distribution,degree and number of excised haemorrhoid piles,and the mean duration of haemorrhoidal disease between the two groups.There was a statistically significant improvement in pain,heaviness,bleeding,pruritus from baseline to the 8th week after operation(P<0.05).Patients taking Diosmin had a shorter hospitalization stay after surgery(P< 0.05).There was also a significant improvement on the proctoscopic appearance(P<0.001).However,there was no statistical difference between the two groups in terms of wound mucosal discharge.Two patients experienced minor bleeding at the 8th week in Diosmin group,and underwent surgery.CONCLUSION:Diosmin is effective in alleviating postoperational symptoms of haemorrhoids.Therefore,it should be considered for the initial treatment after haemorrhoid surgery.However,further prospective randomized trials are needed to confirm the findings of this study.展开更多
AIM:To determine the alterations in rat enterocyte mitochondrial respiratory function and enzyme activities following traumatic brain injury(TBI).METHODS:Fifty-six male SD rats were randomly divided into seven groups(...AIM:To determine the alterations in rat enterocyte mitochondrial respiratory function and enzyme activities following traumatic brain injury(TBI).METHODS:Fifty-six male SD rats were randomly divided into seven groups(8 rats in each group):a control group(rats with sham operation)and traumatic brain injury groups at 6,12,24 h,days 2,3,and 7after operation.TBI models were induced by Feendy’s free-falling method.Mitochondrial respiratory function(respiratory control ratio and ADP/O ratio)was measured with a Clark oxygen electrode.The activities of respiratory chain complexⅠ-Ⅳand related enzymes were determined by spectrophotometry.RESULTS:Compared with the control group,the mitochondrial respiratory control ratio(RCR)declined at 6 h and remained at a low level until day 7 after TBI(control,5.42±0.46;6 h,5.20±0.18;12 h,4.55±0.35;24 h,3.75±0.22;2 d,4.12±0.53;3 d,3.45±0.41;7 d,5.23±0.24,P<0.01).The value of phosphate-to-oxygen(P/O)significantly decreased at12,24 h,day 2 and day 3,respectively(12 h,3.30±0.10;24 h,2.61±0.21;2 d,2.95±0.18;3 d,2.76±0.09,P<0.01)compared with the control group(3.46±0.12).Two troughs of mitochondrial respiratory function were seen at 24 h and day 3 after TBI.The activities of mitochondrial complex Ⅰ (6 h:110±10,12 h:115±12,24 h:85±9,day 2:80±15,day 3:65±16,P<0.01)and complexⅡ(6 h:105±8,12 h:110±92,24 h:80±10,day 2:76±8,day 3:68±12,P<0.01)were increased at 6 h and 12 h following TBI,and then significantly decreased at 24 h,day 2 and day3,respectively.However,there were no differences in complex Ⅰ andⅡactivities between the control and TBI groups.Furthermore,pyruvate dehydrogenase(PDH)activity was significantly decreased at 6 h and continued up to 7 d after TBI compared with the control group(6 h:90±8,12 h:85±10,24 h:65±12,day 2:60±9,day 3:55±6,day 7:88±11,P<0.01).The changes inα-ketoglutaric dehydrogenase(KGDH)activity were similar to PDH,except that the decrease in KGDH activity began at 12 h after TBI(12 h:90±12,24 h:80±9,day 2:76±15,day 3:68±7,day7:90±13,P<0.01).No significant change in malate dehydrogenase(MDH)activity was observed.CONCLUSION:Rat enterocyte mitochondrial respiratory function and enzyme activities are inhibited following TBI.Mitochondrial dysfunction may play an important role in TBI-induced gastrointestinal dysfunction.展开更多
Semiconductor sensitized solar cells(SSSCs) are promising candidates for the third generation of cost-effective photovoltaic solar cells and it is important to develop a group of robust, environment-friendly and visib...Semiconductor sensitized solar cells(SSSCs) are promising candidates for the third generation of cost-effective photovoltaic solar cells and it is important to develop a group of robust, environment-friendly and visible-light-responsive semiconductor sensitizers. In this paper, we first synthesized bismuth vanadate(Bi VO4) quantum dots by employing facile successive ionic layer adsorption and reaction(SILAR) deposition technique, which we then used as a sensitizer for solar energy conversion. The preliminary optimised oxide SSSC showed an efficiency of 0.36%, nearly 2 orders of magnitude enhancement compared with bare Ti O2, due to the narrow bandgap absorption of Bi VO4 quantum dots and intimate contact with the oxide substrate. This result not only demonstrates a simple method to prepare Bi VO4 quantum dots based solar cells, but also provides important insights into the low bandgap oxide SSSCs.展开更多
基金Supported by The Biological Medical Engineering Foundation of First Affiliated Hospital of Xinjiang Medical University
文摘AIM:To demonstrate the value of Diosmin(flavonidic fraction)in the management of post-haemorhoidectomic symptoms.METHODS:Eighty-six consecutive patients with grades ⅢandⅣacute mixed hemorrhoids admitted to the Anorectal Surgical Department of First Affiliated Hospital,Xinjiang Medical University from April 2009 to April 2010,were enrolled in this study.An observerblinded,randomized trial was conducted to compare post-haemorhoidectomic symptoms with use of Diosmin flavonidic fraction vs placebo.Eighty-six patients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk(n=43)or placebo(n=43).The Milligan-Morgan open haemorrhoidectomy was performed by a standardized diathermy excision method.Pain,bleeding,heaviness,pruritus,wound edema and mucosal discharge were observed after surgery.The postoperative symptoms and hospitalization time were recorded.RESULTS:The mean age of the Diosmin group and controls was 53.2 and 51.3 years,respectively.In Diosmin group,haemorrhoid piles were of the third degree in 33 patients and the fourth degree in 10;and in the control group,29 were of the third degree and 14 were of the fourth degree.There was no statistically significance in age,gender distribution,degree and number of excised haemorrhoid piles,and the mean duration of haemorrhoidal disease between the two groups.There was a statistically significant improvement in pain,heaviness,bleeding,pruritus from baseline to the 8th week after operation(P<0.05).Patients taking Diosmin had a shorter hospitalization stay after surgery(P< 0.05).There was also a significant improvement on the proctoscopic appearance(P<0.001).However,there was no statistical difference between the two groups in terms of wound mucosal discharge.Two patients experienced minor bleeding at the 8th week in Diosmin group,and underwent surgery.CONCLUSION:Diosmin is effective in alleviating postoperational symptoms of haemorrhoids.Therefore,it should be considered for the initial treatment after haemorrhoid surgery.However,further prospective randomized trials are needed to confirm the findings of this study.
基金Supported by The Scientific Research Foundation of the Chinese PLA Medical Programs,No.ms031
文摘AIM:To determine the alterations in rat enterocyte mitochondrial respiratory function and enzyme activities following traumatic brain injury(TBI).METHODS:Fifty-six male SD rats were randomly divided into seven groups(8 rats in each group):a control group(rats with sham operation)and traumatic brain injury groups at 6,12,24 h,days 2,3,and 7after operation.TBI models were induced by Feendy’s free-falling method.Mitochondrial respiratory function(respiratory control ratio and ADP/O ratio)was measured with a Clark oxygen electrode.The activities of respiratory chain complexⅠ-Ⅳand related enzymes were determined by spectrophotometry.RESULTS:Compared with the control group,the mitochondrial respiratory control ratio(RCR)declined at 6 h and remained at a low level until day 7 after TBI(control,5.42±0.46;6 h,5.20±0.18;12 h,4.55±0.35;24 h,3.75±0.22;2 d,4.12±0.53;3 d,3.45±0.41;7 d,5.23±0.24,P<0.01).The value of phosphate-to-oxygen(P/O)significantly decreased at12,24 h,day 2 and day 3,respectively(12 h,3.30±0.10;24 h,2.61±0.21;2 d,2.95±0.18;3 d,2.76±0.09,P<0.01)compared with the control group(3.46±0.12).Two troughs of mitochondrial respiratory function were seen at 24 h and day 3 after TBI.The activities of mitochondrial complex Ⅰ (6 h:110±10,12 h:115±12,24 h:85±9,day 2:80±15,day 3:65±16,P<0.01)and complexⅡ(6 h:105±8,12 h:110±92,24 h:80±10,day 2:76±8,day 3:68±12,P<0.01)were increased at 6 h and 12 h following TBI,and then significantly decreased at 24 h,day 2 and day3,respectively.However,there were no differences in complex Ⅰ andⅡactivities between the control and TBI groups.Furthermore,pyruvate dehydrogenase(PDH)activity was significantly decreased at 6 h and continued up to 7 d after TBI compared with the control group(6 h:90±8,12 h:85±10,24 h:65±12,day 2:60±9,day 3:55±6,day 7:88±11,P<0.01).The changes inα-ketoglutaric dehydrogenase(KGDH)activity were similar to PDH,except that the decrease in KGDH activity began at 12 h after TBI(12 h:90±12,24 h:80±9,day 2:76±15,day 3:68±7,day7:90±13,P<0.01).No significant change in malate dehydrogenase(MDH)activity was observed.CONCLUSION:Rat enterocyte mitochondrial respiratory function and enzyme activities are inhibited following TBI.Mitochondrial dysfunction may play an important role in TBI-induced gastrointestinal dysfunction.
基金supported by the National Basic Research Program of China(2011CBA00700)the National High Technology Research and Development Program of China(2011AA050527)the National Natural Science Foundation of China(21403247,21173228,21103197)
文摘Semiconductor sensitized solar cells(SSSCs) are promising candidates for the third generation of cost-effective photovoltaic solar cells and it is important to develop a group of robust, environment-friendly and visible-light-responsive semiconductor sensitizers. In this paper, we first synthesized bismuth vanadate(Bi VO4) quantum dots by employing facile successive ionic layer adsorption and reaction(SILAR) deposition technique, which we then used as a sensitizer for solar energy conversion. The preliminary optimised oxide SSSC showed an efficiency of 0.36%, nearly 2 orders of magnitude enhancement compared with bare Ti O2, due to the narrow bandgap absorption of Bi VO4 quantum dots and intimate contact with the oxide substrate. This result not only demonstrates a simple method to prepare Bi VO4 quantum dots based solar cells, but also provides important insights into the low bandgap oxide SSSCs.
