To the Editor: Neurofibromatosis type 1(NF-1), or Von Recklinghausen disease, is a genetic disorder inherited in an autosomal dominant pattern. It is caused by a mutation in the neurofibromin gene located on chromosom...To the Editor: Neurofibromatosis type 1(NF-1), or Von Recklinghausen disease, is a genetic disorder inherited in an autosomal dominant pattern. It is caused by a mutation in the neurofibromin gene located on chromosome 17, accounting for 96% of all neurofibromatosis cases. This condition can affect multiple systems and often leads to the formation of tumors along the nervous system [1]. Patients with NF-1 may exhibit various symptoms, including Lisch nodules, neurofibromas, scoliosis, café au lait spots, learning disabilities, vision disorders, and epilepsy.展开更多
Objectives: To summarize the characteristics and research progress of influenza-associated brain complications in children and provide references for early diagnosis and brain protection treatment. Methods: Studied pu...Objectives: To summarize the characteristics and research progress of influenza-associated brain complications in children and provide references for early diagnosis and brain protection treatment. Methods: Studied published articles of influenza-associated neurocomplications in children from PubMed and summarizes them from epidemiology, clinical manifestations, diagnosis and treatment, and basic research progress. Results: Common brain complications in flu-children include febrile seizures, influenza-associated encephalopathy (IAE), acute or post-influenza encephalitis, and the most severe condition is acute necrotizing encephalopathy (ANE). However, the mechanism and relevant factors of influenza-associated brain damage have not been elucidated. Conclusion: Influenza could be accompanied by various brain lesion complications in dif ferent stages of the disease, some of which are life-threatening or leave severe neurological sequelae, such as ANE. Due to different brain injury mechanisms, specific early diagnosis and brain protection treatment for different complications are unclear or unanimous. Therefore, further classification and basic research are needed.展开更多
Objective:To evaluate the clinical efficacy of the preoperative digita1 design combined with three dimensional(3D)printing models to assist percutaneous kyphoplasty(PKP)treatment for thoracolumbar compression frac tur...Objective:To evaluate the clinical efficacy of the preoperative digita1 design combined with three dimensional(3D)printing models to assist percutaneous kyphoplasty(PKP)treatment for thoracolumbar compression frac tures.Methods:From January 2018 to August 2020,we obtained data of 99 patients diagnosed thoracolumbar compression fractures.These patients were divided into control group(n=50)underwent traditional PKP surgery,and observation group(n=49)underwent preoperative digital design combined with 3D printing model assisted PKP treatment.The clinical efficacy was evaluated with five parameters,including operation time,number of intraoperative radiographs,visual analogue scale(VAS)score,Cobb Angle change,and high compression rate of injured vertebrae.Results:There were statistically significant differences of operation time and number of intraoperative radio graphs between the two groups(P<0.05).For VAS score,Cobb Angle change and vertebral height compression rate,all of these three parameters were significantly improved when the patients accepted surgery teatment in two groups(P<0.05).However,there were no significant differences between control group and observation group for these three parameters either before or after surgery(P>0.05).Conclusions:Through the design of preoperative surgical guide plate and the application of 3D printing model to guide the operation,the precise design of preoperative surgical puncture site and puncture Angle of the injured vertebra was realized,the number of intraoperative radiographs was reduced,the operation time was shortened and the operation efficiency was improved.展开更多
BACKGROUND Functional epiphora is a clinical condition which is not due to an anatomic defect.Most studies agree that it involves the action of the orbicularis oculi muscle,particularly its deeper segment(Horner’s mu...BACKGROUND Functional epiphora is a clinical condition which is not due to an anatomic defect.Most studies agree that it involves the action of the orbicularis oculi muscle,particularly its deeper segment(Horner’s muscle),but the exact mechanism is not clear.AIM To evaluate the orbicularis oculi muscle in functional epiphora patients using electromyography(EMG).METHODS A total of 8 Chinese patients(16 eyes)with functional epiphora were enrolled in this study,and ten volunteers(10 eyes)were included as normal controls.Five epiphora patients(five eyes)with facial palsy served as positive controls.Quantitative EMG was performed in the deeper segment of orbicularis oculi muscle.The average duration of each EMG waveform was measured.RESULTS The average duration of EMG waveforms in the normal control group,the functional epiphora group,and the facial palsy group were 6.39±0.73 ms,9.39±1.32 ms and 11.2±1.42 ms,respectively.The duration of EMG waveforms was significantly longer in the functional epiphora group than in the normal control group(P<0.05),and shorter than that in the facial palsy group(P<0.05).CONCLUSION These data indicate the presence of neurogenic orbicularis oculi muscle damage in epiphora patients,which may be the cause of functional epiphora.The etiology of neurogenic damage in the orbicularis oculi muscle requires further investigation.展开更多
<i><b>Background:</b></i> To explore the early clinical features and laboratory findings of influenza-associated acute necrotizing encephalopathy (IANE). <i><b>Methods:</i><...<i><b>Background:</b></i> To explore the early clinical features and laboratory findings of influenza-associated acute necrotizing encephalopathy (IANE). <i><b>Methods:</i></b> The demographics data, clinical manifestations, and laboratory indicators of cases diagnosed with IANE and influenza with febrile convulsions (FS), respectively, admitted to Guangzhou Women and Children’s Medical Center from January 2016 to January 2020 were retrospectively analyzed. <i><b>Results:</i></b> Among the 25 cases of IANE, there were 9 males and 16 females, aged 3 to 6 years. The mortality rate was 40.00% (10/25). Influenza virus type A in 9 cases (36.00%) and influenza virus type B in 10 cases (40.00%). The main clinical manifestations of children with IANE were acute disorders of consciousness (64.00%, 16/25) and convulsions (72.00%, 18/25), which were statistically significant when compared with the FS group (P < 0.05). Typical changes on cranial MRI of IANE were cerebral edema, typically with symmetric necrosis of the thalamus and other brain structures. Significant differences (P < 0.05) existed between the IANE and FS groups in laboratory indicators for ALT, AST, CK-MB, LDH, cerebrospinal fluid (CSF) microprotein, CSF LDH, which were above the normal reference range. In addition, logistic regression analysis showed that LDH ≥ 348.5 U/L predicted a significantly higher risk of IANE. <i><b>Conclusions:</i></b> Children with influenza present early with acute impairment of consciousness or convulsive seizures, or with elevated AST, ALT, CK-MB, LDH, and CSF protein and CSF LDH, especially if blood LDH is ≥348.5 U/L, should be closely evaluated and alerted to the possibility of IANE.展开更多
In worldwide,the use of chemical pesticides to protect wood has been greatly restricted.In recent years,a large number of researchers devoted to the search for natural,safe and non-polluting bioactive chemical compoun...In worldwide,the use of chemical pesticides to protect wood has been greatly restricted.In recent years,a large number of researchers devoted to the search for natural,safe and non-polluting bioactive chemical compounds from plants as an alternative to synthetic organic chemical preservative.In Chinese folk,tung oil can be used as paint for wooden furniture to protect them from pests.This study aimed to evaluate the chemical compositions of raw and heated tung oil and their activity against termite.In choice bioassays,weight loss of wood treated with 5%raw or heated tung oil after 4 weeks was significantly less than that of the control group.In no-choice bioassays,there was a significant difference in termite survival and wood weight loss on raw and heated tung oil-treated wood.When tung oil-treatment concentrations increased to 5%,wood weight loss was less than 10%.There was no significant difference in termite survival and wood weight loss between raw and heated tung oil-treated wood.Survival of termites in both tung oil wood treatments was significantly lower than that in the starvation control after 4 weeks.Raw and heated tung oil significantly improved the resistance of pine wood to termites,and have the potential for the development of natural wood preservatives.展开更多
Motivated by the fast evolvement of blockchain technology,cloud-edge platforms,intelligent transportation systems,smart grid,vehicular networks,location based services,and other IoT applications have achieved signific...Motivated by the fast evolvement of blockchain technology,cloud-edge platforms,intelligent transportation systems,smart grid,vehicular networks,location based services,and other IoT applications have achieved significant breakthrough during recent years.Nowadays,blockchain based researches and projects are super-hot topics and focuses for both research and industrial communities.However,most of the current blockchain projects still suffer from insufficient security concerns.The defects of the underlying protocol make the node communication vulnerable to be hijacked,and further exacerbate the fork problem;smart contracts can hardly be fully tested before deployment because of the evolving blockchain platforms,while the smart contracts updating is impossible(or very complicated);current data privacy protection techniques are either inefficient or inaccurate;sharing and cross-chain schemes brought new security problems together with its TPS promotion.The intrinsic security vulnerabilities make the current blockchain based systems and architectures prone to be assaulted,and further do harm to the confidence of the investment on the blockchain industrial.Worse still,blockchain turns out to play a critical role in a lot of existing security solutions,which would be useless if the blockchain is insecure.展开更多
While the internet skills of the elderly is no longer a big problem,it is still necessary to further improve the online shopping experience and activity of the elderly.Evidently,the frequency of seniors shopping onlin...While the internet skills of the elderly is no longer a big problem,it is still necessary to further improve the online shopping experience and activity of the elderly.Evidently,the frequency of seniors shopping online is not nearly as high as the younger generation,as the elderly online shopping frequency is still calculated by weeks.People with higher education and younger age are more likely to accept technology products and understand how to use them,but people with lower education and older age will find it harder to use technology product.The majority of the elderly have a vision for the further development of technology to help them.This study shows that the elderly group shopping demand is large,but when the majority of the elderly choose offline consumption,the option of just a simple online solution is insufficient.Some shopping apps have made improvements in such aspects as font enlargement,color contrast enhancement and simplified operation steps.However,these improvements only solved the superficial problems,and failed to consider and solve the problems based on the experience of the elderly.展开更多
瞄准:与肠的损害在新生的老鼠调查神经元的氮的氧化物 synthase ( nNOS )和可诱导的氮的氧化物 synthase ( i NOS )的动态变化和角色并且定义引起坏死小肠结肠炎( NEC )是否在粘膜与氮的氧化物 synthase ( NOS )的层次被联系影响的肠...瞄准:与肠的损害在新生的老鼠调查神经元的氮的氧化物 synthase ( nNOS )和可诱导的氮的氧化物 synthase ( i NOS )的动态变化和角色并且定义引起坏死小肠结肠炎( NEC )是否在粘膜与氮的氧化物 synthase ( NOS )的层次被联系影响的肠织物。方法:Wistar 老鼠在年龄的不到 24 h 与 5 mg/kg 收到了腹膜内注射脂肪的多糖(LPS ) 。回肠纸巾为 NEC 的组织学的评估并且为 nNOS 和 i NOS 的大小在 1, 3, 6, 12 和 24 h 追随者 LPS 挑战被收集。在肠的损害的度和 NOS 的层次之间的关联是坚定的。结果:注射 LPS 的小狗在损害分数对控制显示出重要增加。nNOS 蛋白质和 mRNA 的表示在 LPS 注射以后被减少。在 nNOS 蛋白质和在 24 h 以内的中部的肠的损害的等级之间有否定重要关联。i NOS 蛋白质和 mRNA 的表示显著地在肠的损害的山峰被增加。结论:nNOS 和 i NOS 在导致 LPS 的肠的损害起不同作用。小心应该在 NEC 有关 NOS 禁止者的潜在的治疗学的使用被施加。展开更多
In this study, we successfully constructed a composite of bone marrow mesenchymal stem cells and a chitosan-collagen scaffold in vitro, transplanted either the composite or bone marrow mesenchymal stem cells alone int...In this study, we successfully constructed a composite of bone marrow mesenchymal stem cells and a chitosan-collagen scaffold in vitro, transplanted either the composite or bone marrow mesenchymal stem cells alone into the ischemic area in animal models, and compared their effects. At 14 days after co-transplantation of bone marrow mesenchymal stem cells and the hi- tosan-collagen scaffold, neurological function recovered noticeably. Vascular endothelial growth factor expression and nestin-labeled neural precursor cells were detected in the iscbemic area, surrounding tissue, hippocampal dentate gyrus and subventricular zone. Simultaneously, a high level of expression of glial fibrillary acidic protein and a low level of expression of neuron-spe- cific enolase were visible in BrdU-labeled bone marrow mesenchymal stem cells. These findings suggest that transplantation of a composite of bone marrow mesenchymal stem cells and a chi- tosan-collagen scaffold has a neuroprotective effect following ischemic stroke.展开更多
The stability of Non-Linear Feedback Shift Registers(NFSRs)plays an important role in the cryptographic security.Due to the complexity of nonlinear systems and the lack of efficient algebraic tools,the theorems relate...The stability of Non-Linear Feedback Shift Registers(NFSRs)plays an important role in the cryptographic security.Due to the complexity of nonlinear systems and the lack of efficient algebraic tools,the theorems related to the stability of NFSRs are still not well-developed.In this paper,we view the NFSR with periodic inputs as a Boolean control network.Based on the mathematical tool of semi-tensor product(STP),the Boolean network can be mapped into an algebraic form.Through these basic theories,we analyze the state space of non-autonomous NFSRs,and discuss the stability of an NFSR with periodic inputs of limited length or unlimited length.The simulation results are provided to prove the efficiency of the model.Based on these works,we can provide a method to analyze the stability of the NFSR with periodic input,including limited length and unlimited length.By this,we can efficiently reduce the computational complexity,and its efficiency is demonstrated by applying the theorem in simulations dealing with the stability of a non-autonomous NFSR.展开更多
A new code concept is used for the L1 civil(L1C) signal of the global positioning system(GPS).The generation of L1C codes is quite different from the generation of traditional ranging codes.Thus,it is necessary to...A new code concept is used for the L1 civil(L1C) signal of the global positioning system(GPS).The generation of L1C codes is quite different from the generation of traditional ranging codes.Thus,it is necessary to find a method for the correct generation to pave the way for future research.L1C codes are based on only one Legendre sequence which consists of Legendre symbols.To calculate these Legendre symbols,the Euler criterion is always used to evaluate quadratic residues.However,due to the great length of L1C codes,this procedure causes overflow problems.Therefore,the quadratic reciprocity law,some related theorems and properties are introduced to solve the problems.Moreover,if the quadratic reciprocity law,some related theorems and properties are used to calculate different Legendre symbols,the combination modes may vary,which causes a complex generation process.The proposed generation method deals with this complex generation process effectively.In addition,through simulations,it is found that the autocorrelation features of obtained Legendre sequences and L1C codes are in accordance with theoretical results,which proves the correctness of the proposed method.展开更多
Inflammatory bowel disease(IBD)is a chronic inflammatory lesion of the intestine,mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota.Conventional treatments for IBD inclu...Inflammatory bowel disease(IBD)is a chronic inflammatory lesion of the intestine,mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota.Conventional treatments for IBD include antibiotics,immunosuppressive agents,5-aminosalicylic acid,steroids and surgery,which have high toxic side effects.Resveratrol is a natural polyphenol,and its various derivatives have anti-oxidation and anti-inflammatory properties.In this paper,we comprehensively review the mechanism of resveratrol and its derivates to alleviate IBD by improving intestinal barrier,regulating the unbalanced gut microbiota,and targeting various inflammatory signaling pathways.展开更多
基金supported by a grant from Zhejiang Provincial Natural Science Foundation (LS21H060001)。
文摘To the Editor: Neurofibromatosis type 1(NF-1), or Von Recklinghausen disease, is a genetic disorder inherited in an autosomal dominant pattern. It is caused by a mutation in the neurofibromin gene located on chromosome 17, accounting for 96% of all neurofibromatosis cases. This condition can affect multiple systems and often leads to the formation of tumors along the nervous system [1]. Patients with NF-1 may exhibit various symptoms, including Lisch nodules, neurofibromas, scoliosis, café au lait spots, learning disabilities, vision disorders, and epilepsy.
文摘Objectives: To summarize the characteristics and research progress of influenza-associated brain complications in children and provide references for early diagnosis and brain protection treatment. Methods: Studied published articles of influenza-associated neurocomplications in children from PubMed and summarizes them from epidemiology, clinical manifestations, diagnosis and treatment, and basic research progress. Results: Common brain complications in flu-children include febrile seizures, influenza-associated encephalopathy (IAE), acute or post-influenza encephalitis, and the most severe condition is acute necrotizing encephalopathy (ANE). However, the mechanism and relevant factors of influenza-associated brain damage have not been elucidated. Conclusion: Influenza could be accompanied by various brain lesion complications in dif ferent stages of the disease, some of which are life-threatening or leave severe neurological sequelae, such as ANE. Due to different brain injury mechanisms, specific early diagnosis and brain protection treatment for different complications are unclear or unanimous. Therefore, further classification and basic research are needed.
基金supported in part by the General Program of Natural Science Foundation of Hubei Province,China(Grant No.2020CFB548)a Project in 2021 of Science and Technology Support Plan of Guizhou Province,China(Grant No.202158413293820389).
文摘Objective:To evaluate the clinical efficacy of the preoperative digita1 design combined with three dimensional(3D)printing models to assist percutaneous kyphoplasty(PKP)treatment for thoracolumbar compression frac tures.Methods:From January 2018 to August 2020,we obtained data of 99 patients diagnosed thoracolumbar compression fractures.These patients were divided into control group(n=50)underwent traditional PKP surgery,and observation group(n=49)underwent preoperative digital design combined with 3D printing model assisted PKP treatment.The clinical efficacy was evaluated with five parameters,including operation time,number of intraoperative radiographs,visual analogue scale(VAS)score,Cobb Angle change,and high compression rate of injured vertebrae.Results:There were statistically significant differences of operation time and number of intraoperative radio graphs between the two groups(P<0.05).For VAS score,Cobb Angle change and vertebral height compression rate,all of these three parameters were significantly improved when the patients accepted surgery teatment in two groups(P<0.05).However,there were no significant differences between control group and observation group for these three parameters either before or after surgery(P>0.05).Conclusions:Through the design of preoperative surgical guide plate and the application of 3D printing model to guide the operation,the precise design of preoperative surgical puncture site and puncture Angle of the injured vertebra was realized,the number of intraoperative radiographs was reduced,the operation time was shortened and the operation efficiency was improved.
文摘BACKGROUND Functional epiphora is a clinical condition which is not due to an anatomic defect.Most studies agree that it involves the action of the orbicularis oculi muscle,particularly its deeper segment(Horner’s muscle),but the exact mechanism is not clear.AIM To evaluate the orbicularis oculi muscle in functional epiphora patients using electromyography(EMG).METHODS A total of 8 Chinese patients(16 eyes)with functional epiphora were enrolled in this study,and ten volunteers(10 eyes)were included as normal controls.Five epiphora patients(five eyes)with facial palsy served as positive controls.Quantitative EMG was performed in the deeper segment of orbicularis oculi muscle.The average duration of each EMG waveform was measured.RESULTS The average duration of EMG waveforms in the normal control group,the functional epiphora group,and the facial palsy group were 6.39±0.73 ms,9.39±1.32 ms and 11.2±1.42 ms,respectively.The duration of EMG waveforms was significantly longer in the functional epiphora group than in the normal control group(P<0.05),and shorter than that in the facial palsy group(P<0.05).CONCLUSION These data indicate the presence of neurogenic orbicularis oculi muscle damage in epiphora patients,which may be the cause of functional epiphora.The etiology of neurogenic damage in the orbicularis oculi muscle requires further investigation.
文摘<i><b>Background:</b></i> To explore the early clinical features and laboratory findings of influenza-associated acute necrotizing encephalopathy (IANE). <i><b>Methods:</i></b> The demographics data, clinical manifestations, and laboratory indicators of cases diagnosed with IANE and influenza with febrile convulsions (FS), respectively, admitted to Guangzhou Women and Children’s Medical Center from January 2016 to January 2020 were retrospectively analyzed. <i><b>Results:</i></b> Among the 25 cases of IANE, there were 9 males and 16 females, aged 3 to 6 years. The mortality rate was 40.00% (10/25). Influenza virus type A in 9 cases (36.00%) and influenza virus type B in 10 cases (40.00%). The main clinical manifestations of children with IANE were acute disorders of consciousness (64.00%, 16/25) and convulsions (72.00%, 18/25), which were statistically significant when compared with the FS group (P < 0.05). Typical changes on cranial MRI of IANE were cerebral edema, typically with symmetric necrosis of the thalamus and other brain structures. Significant differences (P < 0.05) existed between the IANE and FS groups in laboratory indicators for ALT, AST, CK-MB, LDH, cerebrospinal fluid (CSF) microprotein, CSF LDH, which were above the normal reference range. In addition, logistic regression analysis showed that LDH ≥ 348.5 U/L predicted a significantly higher risk of IANE. <i><b>Conclusions:</i></b> Children with influenza present early with acute impairment of consciousness or convulsive seizures, or with elevated AST, ALT, CK-MB, LDH, and CSF protein and CSF LDH, especially if blood LDH is ≥348.5 U/L, should be closely evaluated and alerted to the possibility of IANE.
基金This study was funded by College Students’Scientific Research Training Program of Zhejiang A&F University(No.113-2013200148)ZAFU-Institute of Termite Control of Yuhang cooperative project(2045200485,2045200529).
文摘In worldwide,the use of chemical pesticides to protect wood has been greatly restricted.In recent years,a large number of researchers devoted to the search for natural,safe and non-polluting bioactive chemical compounds from plants as an alternative to synthetic organic chemical preservative.In Chinese folk,tung oil can be used as paint for wooden furniture to protect them from pests.This study aimed to evaluate the chemical compositions of raw and heated tung oil and their activity against termite.In choice bioassays,weight loss of wood treated with 5%raw or heated tung oil after 4 weeks was significantly less than that of the control group.In no-choice bioassays,there was a significant difference in termite survival and wood weight loss on raw and heated tung oil-treated wood.When tung oil-treatment concentrations increased to 5%,wood weight loss was less than 10%.There was no significant difference in termite survival and wood weight loss between raw and heated tung oil-treated wood.Survival of termites in both tung oil wood treatments was significantly lower than that in the starvation control after 4 weeks.Raw and heated tung oil significantly improved the resistance of pine wood to termites,and have the potential for the development of natural wood preservatives.
基金supported by Key-Area Research and Develop-ment Program of Guangdong Province 2020B0101090003。
文摘Motivated by the fast evolvement of blockchain technology,cloud-edge platforms,intelligent transportation systems,smart grid,vehicular networks,location based services,and other IoT applications have achieved significant breakthrough during recent years.Nowadays,blockchain based researches and projects are super-hot topics and focuses for both research and industrial communities.However,most of the current blockchain projects still suffer from insufficient security concerns.The defects of the underlying protocol make the node communication vulnerable to be hijacked,and further exacerbate the fork problem;smart contracts can hardly be fully tested before deployment because of the evolving blockchain platforms,while the smart contracts updating is impossible(or very complicated);current data privacy protection techniques are either inefficient or inaccurate;sharing and cross-chain schemes brought new security problems together with its TPS promotion.The intrinsic security vulnerabilities make the current blockchain based systems and architectures prone to be assaulted,and further do harm to the confidence of the investment on the blockchain industrial.Worse still,blockchain turns out to play a critical role in a lot of existing security solutions,which would be useless if the blockchain is insecure.
文摘While the internet skills of the elderly is no longer a big problem,it is still necessary to further improve the online shopping experience and activity of the elderly.Evidently,the frequency of seniors shopping online is not nearly as high as the younger generation,as the elderly online shopping frequency is still calculated by weeks.People with higher education and younger age are more likely to accept technology products and understand how to use them,but people with lower education and older age will find it harder to use technology product.The majority of the elderly have a vision for the further development of technology to help them.This study shows that the elderly group shopping demand is large,but when the majority of the elderly choose offline consumption,the option of just a simple online solution is insufficient.Some shopping apps have made improvements in such aspects as font enlargement,color contrast enhancement and simplified operation steps.However,these improvements only solved the superficial problems,and failed to consider and solve the problems based on the experience of the elderly.
文摘瞄准:与肠的损害在新生的老鼠调查神经元的氮的氧化物 synthase ( nNOS )和可诱导的氮的氧化物 synthase ( i NOS )的动态变化和角色并且定义引起坏死小肠结肠炎( NEC )是否在粘膜与氮的氧化物 synthase ( NOS )的层次被联系影响的肠织物。方法:Wistar 老鼠在年龄的不到 24 h 与 5 mg/kg 收到了腹膜内注射脂肪的多糖(LPS ) 。回肠纸巾为 NEC 的组织学的评估并且为 nNOS 和 i NOS 的大小在 1, 3, 6, 12 和 24 h 追随者 LPS 挑战被收集。在肠的损害的度和 NOS 的层次之间的关联是坚定的。结果:注射 LPS 的小狗在损害分数对控制显示出重要增加。nNOS 蛋白质和 mRNA 的表示在 LPS 注射以后被减少。在 nNOS 蛋白质和在 24 h 以内的中部的肠的损害的等级之间有否定重要关联。i NOS 蛋白质和 mRNA 的表示显著地在肠的损害的山峰被增加。结论:nNOS 和 i NOS 在导致 LPS 的肠的损害起不同作用。小心应该在 NEC 有关 NOS 禁止者的潜在的治疗学的使用被施加。
基金funded by a grant from Shaanxi Provincial Support Project of Scientific Research Development Plan of China,No.2012KCT-16
文摘In this study, we successfully constructed a composite of bone marrow mesenchymal stem cells and a chitosan-collagen scaffold in vitro, transplanted either the composite or bone marrow mesenchymal stem cells alone into the ischemic area in animal models, and compared their effects. At 14 days after co-transplantation of bone marrow mesenchymal stem cells and the hi- tosan-collagen scaffold, neurological function recovered noticeably. Vascular endothelial growth factor expression and nestin-labeled neural precursor cells were detected in the iscbemic area, surrounding tissue, hippocampal dentate gyrus and subventricular zone. Simultaneously, a high level of expression of glial fibrillary acidic protein and a low level of expression of neuron-spe- cific enolase were visible in BrdU-labeled bone marrow mesenchymal stem cells. These findings suggest that transplantation of a composite of bone marrow mesenchymal stem cells and a chi- tosan-collagen scaffold has a neuroprotective effect following ischemic stroke.
基金This work is supported by the National Natural Science Foundation of China(Grants Nos.61672020,U1803263,61662069,61762068,31560622,31260538,30960246,31672385,71761029)Project funded by China Postdoctoral Science Foundation(2013M542560,2015T81129)+6 种基金A Project of Shandong Province Higher Educational Science and Technology Program(No.J16LN61)Inner Mongolia Colleges and Universities Scientific and Technological Research Projects(Grant No.NJZC17148)CERNET Innovation Project(No.NGII20161209)Natural Science Foundation of Inner Mongolia Autonomous Region of china(No.2017MS0610,No.2017MS717)Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(No.NJYT-18-A13)Inner Mongolia Key Laboratory of economic data analysis and mining China-Mongolia Scientific Research Capacity Building of Incubator,Joint Laboratory and Technology Transfer Center,Education research project of national finance and economics(No.MZCJYB1803)Postgraduate research and innovation project of Inner Mongolia university of finance and economics.
文摘The stability of Non-Linear Feedback Shift Registers(NFSRs)plays an important role in the cryptographic security.Due to the complexity of nonlinear systems and the lack of efficient algebraic tools,the theorems related to the stability of NFSRs are still not well-developed.In this paper,we view the NFSR with periodic inputs as a Boolean control network.Based on the mathematical tool of semi-tensor product(STP),the Boolean network can be mapped into an algebraic form.Through these basic theories,we analyze the state space of non-autonomous NFSRs,and discuss the stability of an NFSR with periodic inputs of limited length or unlimited length.The simulation results are provided to prove the efficiency of the model.Based on these works,we can provide a method to analyze the stability of the NFSR with periodic input,including limited length and unlimited length.By this,we can efficiently reduce the computational complexity,and its efficiency is demonstrated by applying the theorem in simulations dealing with the stability of a non-autonomous NFSR.
基金supported by the National High Technology Research and Development Program of China(863Program)(2011AA110101)the National Basic Research Program of China(973Program)(2009CB724002)
文摘A new code concept is used for the L1 civil(L1C) signal of the global positioning system(GPS).The generation of L1C codes is quite different from the generation of traditional ranging codes.Thus,it is necessary to find a method for the correct generation to pave the way for future research.L1C codes are based on only one Legendre sequence which consists of Legendre symbols.To calculate these Legendre symbols,the Euler criterion is always used to evaluate quadratic residues.However,due to the great length of L1C codes,this procedure causes overflow problems.Therefore,the quadratic reciprocity law,some related theorems and properties are introduced to solve the problems.Moreover,if the quadratic reciprocity law,some related theorems and properties are used to calculate different Legendre symbols,the combination modes may vary,which causes a complex generation process.The proposed generation method deals with this complex generation process effectively.In addition,through simulations,it is found that the autocorrelation features of obtained Legendre sequences and L1C codes are in accordance with theoretical results,which proves the correctness of the proposed method.
基金financial supported by the key research and development of general projects of Jiangxi province(20192BBF60026).
文摘Inflammatory bowel disease(IBD)is a chronic inflammatory lesion of the intestine,mainly manifested by infiltration of intestinal inflammatory cells and imbalance of gut microbiota.Conventional treatments for IBD include antibiotics,immunosuppressive agents,5-aminosalicylic acid,steroids and surgery,which have high toxic side effects.Resveratrol is a natural polyphenol,and its various derivatives have anti-oxidation and anti-inflammatory properties.In this paper,we comprehensively review the mechanism of resveratrol and its derivates to alleviate IBD by improving intestinal barrier,regulating the unbalanced gut microbiota,and targeting various inflammatory signaling pathways.