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HIF-1α在腹泻型肠易激综合征中的表达及作用研究
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作者 贺星 王得春 +3 位作者 次旦罗布 惠升 许韬 唐郡 《现代消化及介入诊疗》 2023年第1期47-49,56,共4页
目的 明确缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)在腹泻型肠易激综合征(Diarrhoea-predominant Irritable bowel syndrome, IBS-D)中的表达及作用。方法 30只雌性SPF级Wistar大鼠随机分为模型组、干预组和对照组各10... 目的 明确缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)在腹泻型肠易激综合征(Diarrhoea-predominant Irritable bowel syndrome, IBS-D)中的表达及作用。方法 30只雌性SPF级Wistar大鼠随机分为模型组、干预组和对照组各10只,模型组大鼠接受29天的急-慢结合应激法构建IBS-D模型,干预组在构建IBS-D大鼠模型同时接受吡咯烷二硫代甲酸铵(PDTC)腹腔注射,对照组大鼠无特殊处理。观察造模效果(比较模型组与对照组1 h排便量、湿便率及疼痛压力阈值差异,观察模型组大鼠肠组织大体标本完整性),比较三组大鼠肠黏膜HIF-1α及核因子κB(nuclear factor-κB,NF-κB)表达差异。结果三组大鼠均顺利完成实验,无死亡。模型组大鼠1 h排便量(7.10±0.88 vs 0.90±0.32)、湿便率(11.15±0.98 vs 0)明显高于对照组,差异有统计学意义(P<0.05);疼痛压力阈值(27.88±1.48 vs 30.50±2.42)明显低于对照组,差异有统计学意义(P<0.05);模型组大鼠结肠黏膜未见明显充血、水肿、糜烂、溃疡。免疫印迹法观察对照组大鼠HIF-1α染色最浅,干预组次之,均明显浅于模型组大鼠;对照组大鼠NF-κB染色最浅,干预组次之,模型组大鼠染色最深。结论 HIF-1α在IBS-D大鼠中肠黏膜中高表达,其可能通过抑制NF-κB对IBS-D起到保护作用。 展开更多
关键词 腹泻型肠易激综合征 缺氧诱导因子-1Α 核因子ΚB 作用机制
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Ulva prolifera subpixel mapping with multiple-feature decision fusion
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作者 Jianhua WAN Xianci WAN +5 位作者 Lie SUN Mingming XU hui sheng Shanwei LIU Bin ZOU Qimao WANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第3期865-880,共16页
The unavoidable nature of Ulva prolifera mixed pixel in low-resolution remote sensing images would result in rough boundary of U.prolifera patches,omission of tiny patches,and overestimation of coverage area.The decom... The unavoidable nature of Ulva prolifera mixed pixel in low-resolution remote sensing images would result in rough boundary of U.prolifera patches,omission of tiny patches,and overestimation of coverage area.The decomposition of U.prolifera mixed pixel addresses the issue of coverage area overestimation,and the remaining problems can be alleviated by subpixel mapping(SPM).Due to the drift and dissipation of U.prolifera,a suitable SPM method is the single image-based unsupervised method.However,the method has difficulties in detail reconstruction,insufficient learning of spectral information,and SPM error introduced by abundance deviation.Therefore,we proposed a multiple-feature decision fusion SPM(MFDFSPM)method.It involves three branches to obtain the spatial,abundance,and spectral features of U.prolifera while considers multi-feature information using the fusion strategy.Experiments on the Geostationary Ocean Color Imager images in the Yellow Sea of China indicate that the MFDFSPM overperforms several typical U.prolifera SPM methods in higher accuracy and stronger robustness in both SPM and abundance calculation,which produced subpixel map with more detailed spatial information and less noise. 展开更多
关键词 Ulva prolifera subpixel mapping multiple-feature decision fusion abundance geostationary ocean color imager(GOCI)
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A multi-module with a two-way feedback method for Ulva drift-diffusion
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作者 hui sheng Jianmeng Li +7 位作者 Qimao Wang Bin Zou Lijian Shi Mingming Xu Shanwei Liu Jianhua Wan Zhe Zeng Yanlong Chen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第12期118-134,共17页
The outbreak of Ulva in the Yellow Sea has seriously affected marine ecology and economic activities.Therefore,effective prediction of the distribution of Ulva is of great significance for disaster prevention and redu... The outbreak of Ulva in the Yellow Sea has seriously affected marine ecology and economic activities.Therefore,effective prediction of the distribution of Ulva is of great significance for disaster prevention and reduction.However,the prediction method of Ulva is mainly based on numerical simulation.There are two problems with these methods.First is that the initial distribution of Ulva is simulated using independent pixel-level particles.Besides,the influence of Ulva growth and diffusion on the drift is not considered.Therefore,this paper proposes a multi-module with a two-way feedback method(MTF)to solve the above problems.The main contributions of our approach are summarized as follows.First,the initialization module,the generation and elimination module,and the drive module are composed in our way.Second,we proposed an initialization method using rectangle objects to simulate the Ulva distribution extracted from remote sensing images.Thirdly,the drift and diffusion mechanism of the Ulva is considered to realize the two-way feedback between the generation and elimination module and the drive module.The results of our experiments show that the MTF performs better than the traditional method in predicting the drift and diffusion of Ulva.The code is already publicly available at https://github.com/UPCGIT/A-multi-module-with-a-two-way-feedback-method-for-Ulva-drift-diffusion. 展开更多
关键词 ULVA remote sensing DRIFT DIFFUSION FEEDBACK
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Efficacy and outcome of extensive intraoperative peritoneal lavage plus surgery vs surgery alone with advanced gastric cancer patients
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作者 En-Dong Song Heng-Bo Xia +11 位作者 Li-Xiang Zhang Jun Ma Pan-Quan Luo Lai-Zhi Yang Ben-Hong Xiang Bai-Chuan Zhou Lei Chen hui sheng Yin Fang Wen-Xiu Han Zhi-Jian Wei A-Man Xu 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第3期430-439,共10页
BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors.After resection,one of the major problems is its peritoneal dissemination and recurrence.Some free cancer cells may still exist after resection.I... BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors.After resection,one of the major problems is its peritoneal dissemination and recurrence.Some free cancer cells may still exist after resection.In addition,the surgery itself may lead to the dissemination of tumor cells.Therefore,it is necessary to remove residual tumor cells.Recently,some researchers found that extensive intraoperative peritoneal lavage(EIPL)plus intraperitoneal chemotherapy can improve the prognosis of patients and eradicate peritoneal free cancer for GC patients.However,few studies explored the safety and long-term outcome of EIPL after curative gastrectomy.AIM To evaluate the efficacy and long-term outcome of advanced GC patients treated with EIPL.METHODS According to the inclusion and exclusion criteria,a total of 150 patients with advanced GC were enrolled in this study.The patients were randomly allocated to two groups.All patients received laparotomy.For the non-EIPL group,peritoneal lavage was washed using no more than 3 L of warm saline.In the EIPL group,patients received 10 L or more of saline(1 L at a time)before the closure of the abdomen.The surviving rate analysis was compared by the Kaplan-Meier method.The prognostic factors were carried out using the Cox appropriate hazard pattern.RESULTS The basic information in the EIPL group and the non-EIPL group had no significant difference.The median follow-up time was 30 mo(range:0-45 mo).The 1-and 3-year overall survival(OS)rates were 71.0%and 26.5%,respectively.The symptoms of ileus and abdominal abscess appeared more frequently in the non-EIPL group(P<0.05).For the OS of patients,the EIPL,Borrmann classification,tumor size,N stage,T stage and vascular invasion were significant indicators.Then multivariate analysis revealed that EIPL,tumor size,vascular invasion,N stage and T stage were independent prognostic factors.The prognosis of the EIPL group was better than the non-EIPL group(P<0.001).The 3-year survival rate of the EIPL group(38.4%)was higher than the non-EIPL group(21.7%).For the recurrence-free survival(RFS)of patients,the risk factor of RFS included EIPL,N stage,vascular invasion,type of surgery,tumor location,Borrmann classification,and tumor size.EIPL and tumor size were independent risk factors.The RFS curve of the EIPL group was better than the non-EIPL group(P=0.004),and the recurrence rate of the EIPL group(24.7%)was lower than the non-EIPL group(46.4%).The overall recurrence rate and peritoneum recurrence rate in the EIPL group was lower than the non-EIPL group(P<0.05).CONCLUSION EIPL can reduce the possibility of perioperative complications including ileus and abdominal abscess.In addition,the overall survival curve and RFS curve were better in the EIPL group. 展开更多
关键词 Extensive intraoperative peritoneal lavage Advanced gastric cancer Prognosis RECURRENCE Overall survival
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基于唐咀水下遗址的青铜文创博物馆研究 被引量:1
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作者 潘峰 回声 李季 《铜陵学院学报》 2017年第6期100-102,共3页
考古工作者在巢湖市烔炀镇唐咀村北侧发现了水下遗址,该遗址历史久远、文物资源丰富,初步具备文化传承和推广价值。通过深入研究和定位,提出以青铜文化为主的唐咀水下遗址文创博物馆实践策略,注重展示体验和文创衍生,进一步提升了该遗... 考古工作者在巢湖市烔炀镇唐咀村北侧发现了水下遗址,该遗址历史久远、文物资源丰富,初步具备文化传承和推广价值。通过深入研究和定位,提出以青铜文化为主的唐咀水下遗址文创博物馆实践策略,注重展示体验和文创衍生,进一步提升了该遗址的文化产品创新能力,进而把烔炀镇唐咀村打造成环巢文创乐园,实现古巢文明传播的初衷。 展开更多
关键词 唐咀水下遗址 青铜博物馆 文创策划 文明传播
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一维平面火焰OH基绝对浓度值的测量与分析 被引量:2
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作者 张蕾 孙锐 +3 位作者 杨振 彭江波 回胜 邹高鹏 《燃烧科学与技术》 EI CAS CSCD 北大核心 2017年第2期161-165,共5页
针对甲烷/空气预混气体层流平面火焰,利用LIF技术,采用双向光路法对燃烧过程中所产生的OH基进行了测量,得到其一维绝对浓度值及其空间分布,并分析其产生的动力学因素.结果表明,当量比为0.8~1.0范围内,OH基绝对浓度差别不大;当量比在1.1~... 针对甲烷/空气预混气体层流平面火焰,利用LIF技术,采用双向光路法对燃烧过程中所产生的OH基进行了测量,得到其一维绝对浓度值及其空间分布,并分析其产生的动力学因素.结果表明,当量比为0.8~1.0范围内,OH基绝对浓度差别不大;当量比在1.1~1.3的范围内,OH基的绝对浓度呈下降趋势,一方面由于OH基消耗反应OH+CH_4→CH_3+H2O,随着CH_4量的增大,OH基的消耗速度增加,另一方面OH基生成反应CH_3+O_2→OH+CH2O,虽然CH_3不断生成,但由于O_2的流量逐渐减小,所以OH基的生成率逐渐下降,二者共同作用导致OH基绝对浓度随着当量比的增大而减小.实验所测OH基绝对浓度值与Versluis等测得的OH基绝对浓度的数量级相差不大. 展开更多
关键词 OH基 绝对浓度 LIF 双向光路法 平面火焰
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A fast,edge-preserving,distance-regularized model with bilateral filtering for oil spill segmentation of SAR images 被引量:3
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作者 Wandi WANG hui sheng +4 位作者 Yanlong CHEN Shanwei LIU Jijun MAO Zhe ZENG Jianhua WAN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2021年第4期1198-1210,共13页
Marine oil spills are among the most significant sources of marine pollution.Synthetic aperture radar(SAR)has been used to improve oil spill observations because of its advantages in oil spill detection and identifica... Marine oil spills are among the most significant sources of marine pollution.Synthetic aperture radar(SAR)has been used to improve oil spill observations because of its advantages in oil spill detection and identification.However,speckle noise,weak boundaries,and intensity inhomogeneity often exist in the oil spill regions of SAR imagery,which will seriously aff ect the accurate identification of oil spills.To enhance marine oil spill segmentation of SAR images,a fast,edge-preserving framework based on the distance-regularized level set evolution(DRLSE)model was proposed.Specifically,a bilateral filter penalty term is designed and incorporated into the DRLSE energy function(BF-DRLSE)to preserve the edges of oil spills,and an adaptive initial box boundary was selected for the DRLSE model to reduce the operation time complexity.Two sets of RadarSat-2 SAR data were used to test the proposed method.The experimental results indicate that the bilateral filtering scheme incorporated into the energy function during level set evolution improved the stability of level set evolution.Compared with other methods,the proposed improved BF-DRLSE algorithm displayed a higher overall segmentation accuracy(97.83%).In addition,using an appropriate initial box boundary for the DRLSE method accelerated the global search process,improved the accuracy of oil spill segmentation,and reduced computational time.Therefore,the results suggest that the proposed framework is eff ective and applicable for marine oil spill segmentation. 展开更多
关键词 level sets bilateral filter marine oil spill segmentation synthetic aperture radar(SAR)imagery
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锂电正极材料金属及磁性异物过程控制的研究 被引量:3
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作者 惠升 詹永丽 黎江 《世界有色金属》 2021年第17期166-168,共3页
锂离子电池正极及前驱体材料中金属及磁性异物的存在对其电性能影响较大。本文对制程过程中金属与磁性异物引入及防范管控手段进行相关研究和论述,为锂电正极材料金属及磁性异物的质量管理提供改善经验。
关键词 正极/前驱体材料 金属异物 磁性异物 Cu/Zn单质 质量管理
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Radial velocity of ocean surface current estimated from SAR Doppler frequency measurements—a case study of Kuroshio in the East China Sea
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作者 Lihua Wang Benwei Shi +4 位作者 Yunxuan Zhou hui sheng Yanghua Gao Li Fan Ziheng Yang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2021年第12期135-147,共13页
Ocean currents are a key element in ocean processes and in meteorology,affecting material transport and modulating climate change patterns.The Doppler frequency shift information of the synthetic aperture radar(SAR)ec... Ocean currents are a key element in ocean processes and in meteorology,affecting material transport and modulating climate change patterns.The Doppler frequency shift information of the synthetic aperture radar(SAR)echo signal can reflect the dynamic characteristics of the sea surface,and has become an essential sea surface dynamic remote sensing parameter.Studies have verified that the instantaneous Doppler frequency shift can realize the SAR detection of the sea surface current.However,the validation of SAR-derived ocean current data and a thorough analysis of the errors associated with them remain lacking.In this study,we derive high spatial resolution flow measurements for the Kuroshio in the East China Sea from SAR data using a theoretical model of shifts in Doppler frequency driven by ocean surface current.Global ocean multi observation(MOB)products and global surface Lagrangian drifter(GLD)data are used to validate the Kuroshio flow retrieved from the SAR data.Results show that the central flow velocity for the Kuroshio derived from the SAR is 0.4–1.5 m/s.The error distribution between SAR ocean currents and MOB products is an approximate standard normal distribution,with the 90%confidence interval concentrated between–0.1 m/s and 0.1 m/s.Comparative analysis of SAR ocean current and GLD products,the correlation coefficient is 0.803,which shows to be significant at a confidence level of 99%.The cross-validation of different ocean current dataset illustrate that the SAR radial current captures the positions and dynamics of the Kuroshio central flow and the Kuroshio Counter Current,and has the capability to monitor current velocity over a wide range of values. 展开更多
关键词 Doppler frequency radial velocity ocean current SAR KUROSHIO
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开放教育下基于微课的翻转课堂资源建设策略
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作者 回声 《数码设计》 2018年第13期242-242,共1页
在开放教育背景下,我国教学面临着新的形势与要求。有效应用微课建设翻转课堂能够激发学习者学习兴趣,促进教学目标实现。本文针对开放教育特点,提出微课模式下翻转课堂资源建设的相关策略,希望能为翻转课堂模式的研究发展以及其他学科... 在开放教育背景下,我国教学面临着新的形势与要求。有效应用微课建设翻转课堂能够激发学习者学习兴趣,促进教学目标实现。本文针对开放教育特点,提出微课模式下翻转课堂资源建设的相关策略,希望能为翻转课堂模式的研究发展以及其他学科提供应用教学的启示。 展开更多
关键词 开放教育 微课 翻转课堂 资源建设
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解剖性肝Ⅷ段切除联合右肝静脉切除重建术治疗复发性肝包虫病 被引量:1
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作者 王得春 卜晨晨 +4 位作者 次旦罗布 惠升 蔡龙 万晨光 陈志宇 《中华消化外科杂志》 CAS CSCD 北大核心 2018年第12期1231-1233,共3页
1临床资料患者女,55岁。因“反复右季肋区疼痛5年”于2018年6月21日收治入院。患者5年前进食油腻食物后出现右季肋区疼痛,以持续性钝痛为主,伴右侧肩背部放射疼痛,疼痛能忍受,伴畏寒、发热,体温达39.0℃,伴恶心、呕吐,呕吐物为胃内容物... 1临床资料患者女,55岁。因“反复右季肋区疼痛5年”于2018年6月21日收治入院。患者5年前进食油腻食物后出现右季肋区疼痛,以持续性钝痛为主,伴右侧肩背部放射疼痛,疼痛能忍受,伴畏寒、发热,体温达39.0℃,伴恶心、呕吐,呕吐物为胃内容物,呕吐后腹痛缓解不明显。 展开更多
关键词 肝包虫病 肝包虫外囊摘除术 肝包虫内囊摘除术 解剖性肝切除术 肝静脉重建
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