血糖信息化管理系统对2型糖尿病患者治疗效果及自我管理能力的影响分析

目的分析血糖信息化管理系统对糖尿病患者的疗效及自我管理能力的影响。方法实施全院血糖管理前,随机选取2016年1月-2016年6月在郑州人民医院治疗的112例2型糖尿病患者为对照组;实施全院血糖管理后,选取2016年7月-2016年12月该院收治的112例手术患者为观察组。对照组患者采用传统床旁血糖仪及血糖管理模式;观察组患者采用全信息化血糖管理模式。对比患者的自我管理能力的改变,检测患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)、三酰甘油(TG)、总胆固醇(TC)及糖化血红蛋白(Hb A1c)等指标进行比较。结果观察组对血糖相关知识的知晓率、血糖达标率及糖化血红蛋白达标率高于对照组(P<0.05)。观察组的自测血糖率、适当运动率、合理饮食率及规范用药率均高于对照组(P<0.05)。观察组的FPG、2 h PG、TC、TG及Hb AIc低于对照组(P<0.05)。结论医院实施全院血糖信息化管理后,方便医护人员获取患者信息,纠正患者不良生活习惯,有效改善患者的血糖指标,提高患者对医院服务的满意度。

Prediction of active ingredients and potential mechanisms of Alisma decoction against atherosclerosis:A study based on UHPLC-Q-Orbitrap-HRMS and network pharmacology

Background:Atherosclerosis(AS)has been a potentially life-threatening disease worldwide.Alisma decoction(AD)is a famous Chinese formula in treating AS.However,the active components and potential mechanisms remain unknown.Methods:In this study,the active compositions of AD were analyzed by ultrahigh-performance liquid chromatography quadrupole-orbitrap high-resolution mass spectrometry(UHPLC-Q-Orbitrap-HRMS).The putative targets were predicted and interpreted by a series of bio-informative tools such as Venn,STRING,NetworkAnalyzer,ClusterMarker,and DAVID.Finally,the results were validated by molecular docking using AutoDock.Results:The results showed that alisol A,alisol B,23-o-Acetylalisol B,atractylenolideⅢand atractylenolideⅡwere the major compositions in AD.Thirty targets mainly distributed in three gene clusters were obtained after topological and cluster analysis.KEGG and GO analyses showed that genes in cluster 1 mainly participated in adipocytokine signaling pathway and played an important role in lipid metabolism,while genes in cluster 2 had regulatory actions via cAMP signaling pathway and may protect vascular function from AS,and genes in cluster 3 were closely related to inflammation.Furthermore,RXRA,AGT and CXCL8,the central gene of cluster 1,2 and 3,were verified to be strong binding with some major compositions in AD.Conclusion:The possible mechanisms of AD in the treatment of AS may be closely correlated with the regulation of lipid metabolism,vascular physiology and inflammation.Our study provided a new insight into the anti-AS effect of AD,but more pharmacological experiments should be performed for verification in the future.

Diagnostic and prognostic role of long noncoding RNA MALAT1 in breast cancer:a meta-analysis

Background:This systematic analysis aspired to investigate the diagnostic and prognostic role of metastasis associated lung adenocarcinoma transcript 1(MALAT1)in breast cancer.Methods:We conducted a search in PubMed,EMBASE,MEDLINE,Web of Science,CNKI,Wanfang and VIP databases to identify eligible articles,and combined the effect sizes using Stata 15.0 and Meta-Disc 1.4.Results:19 articles were identifed in our study,including 9 diagnostic articles and 11 prognostic articles.For the diagnostic meta-analysis,the pooled specificity,sensitivity,diagnostic odds ratio,area under the curve of MALAT1 in confirming breast cancer were 0.77(95%confidence interval(CI):0.68-0.84),0.81(95%CI:0.71-0.88),14.09(95%CI:6.34-31.31)and 0.85(95%CI:0.82-0.88),separately.The subgroup analysis demonstrated that the diagnostic effect of MALAT1 in triple negative breast cancer was higher than in breast cancer.For the survival outcomes meta-analysis,patients with over-expression of MALAT1 had poor overall survival,recurrence free survival,metastasis-free survival,disease specific survival and disease free survival.Conclusion:MALAT1 may serve as a promising biomarker for diagnosis and prognosis for confirming breast cancer.

Clinical efficacy of integrated Chinese and western medicine in the treatment of the corona virus disease 2019(COVID-19):A meta-analysis

Objective:To evaluate the clinical efficacy of integrated Chinese and western medicine(ICWM)in the treatment of COVID-19.Methods:Literature retrieval was performed in PubMed,Cochrane Library,EMBASE,Web of science,CNKI,VIP and Wanfang database from inception to November 1,2020.The data extraction and quality assessment were completed by two independent reviewers.Meta-analysis was performed using Review Manager 5.3.Results:30 clinical trials were included with 3379 participants.The meta-analysis showed that there were significant differences in the total effective rate(RR=1.24,95%CI[1.15,1.35];P<0.01),the conversion rate from mild or moderate to severe(RR=0.32,95%CI[0.24,0.44];P<0.01),the mortality(RR=0.52,95%CI[0.30,0.93];P<0.05),the disappearance time of fever(MD=-1.60,95%CI[-1.99,-1.21];P<0.01)and cough(MD=-1.43,95%CI[-1.96,-0.90];P<0.01)and fatigue(MD=-1.44,95%CI[-2.33,-0.55];P<0.01),the rate of CT improvement(RR=1.29,95%CI[1.13,1.47];P<0.01)and the rate of adverse reactions(RR=0.52,95%CI[0.31,0.87];P<0.05)between ICWM and western medicine(WM)alone.While there were no differences between two groups in the cure rate(RR=1.22,95%CI[0.98,1.52];P>0.05)and the disappearance rate of fatigue(RR=1.18,95%CI[0.97,1.45];P>0.05).Conclusion:Meta-analysis results indicated that ICWM in the treatment of COVID-19 can improve clinical efficacy and safety.However,high-quality,large-sample,multi-center RCTs are required to confirm the efficacy of traditional Chinese medicine intervention COVID-19.

Research progress of traditional Chinese medicine in the treatment of breast cancer based on “Binding of Phlegm and Stasis”

Breast cancer is a common malignancy in female,which seriously endangers women’s health.Chinese medicine believed that the incidence of breast cancer is related to“Stagnation of Liver-Qi”and“Phlegm,Disharmony of Thoroughfare and Conception Vessels”,“Stagnation of Qi and Blood Stasis”,constitution and other characteristics.Modern research believed that phlegm is related to abnormal energy metabolism of tumor cells,and stasis is the pathological change of tumor angiogenesis.How to combine tumor angiogenesis and energy replacement abnormality with the theory of“Binding of Phlegm and Stasis”has become a new direction of traditional Chinese medicine anti-tumor research.The drugs of“Activating Blood Circulation”and“Removing Blood Stasis”,“Resolving Phlegm”and“Dispersing Constipation”have a wide range of pharmacological effects and definite curative effect.They have the functions of anti-inflammatory,anti-tumor,anti-pathogenic microorganism and improving the immune ability of the body.In this paper,the effects and mechanisms of phlegm-reducing and stasis dispersing active ingredients and compound preparations in regulating angiogenesis and energy metabolism of breast cancer were reviewed,and the differences in efficacy,targets and pathways of Phlegm-Reducing and Stasis Dispersing drugs were summarized,so as to provide some reference for the research and development of traditional Chinese medicine for breast cancer.