Due to the high affinity between dithiocarbamate (DTC) and Hg2+, a fluorescent probe based on squaraine chromophore with DTC side arm for Hg2+ via coordination induced deaggregation signaling has been designed and...Due to the high affinity between dithiocarbamate (DTC) and Hg2+, a fluorescent probe based on squaraine chromophore with DTC side arm for Hg2+ via coordination induced deaggregation signaling has been designed and synthesized. Squaraine has a high tendency to aggregate in aqueous solution, and such self-aggregation usually results in a dramatic absorption spectral broadening with fluorescence emission quenching. The combination of the DTC side arm of the probe with Hg2+ induces steric hindrance, leading to the deaggregation of the dye complex, companying with a fluorescence emission restoration. In EtOH-H2O (20:80, v/v) solution, this "turn on" fluorescent probe has high selectivity and sensitivity toward Hg2+ over other metal ions, and the limit of detection for Hg2+ was estimated as 2.19 × 10^-8 mol/L by 3σ/k.展开更多
To the Editor: A 12-year-old boy born in Guizhou Province, China, presented with a history of generalized raised nodular lesions developing over the course of 2 months on the face and limbs. The patient's first symp...To the Editor: A 12-year-old boy born in Guizhou Province, China, presented with a history of generalized raised nodular lesions developing over the course of 2 months on the face and limbs. The patient's first symptom was the appearance of small nodules on the face, unaccompanied by sensations of itching, pain, or burning.展开更多
Thanks for your careful reading and priceless comments to our recent publication.N Although the incidence and prevalence of leprosy have declined significantly in recent decades, leprosy will probably persist as a maj...Thanks for your careful reading and priceless comments to our recent publication.N Although the incidence and prevalence of leprosy have declined significantly in recent decades, leprosy will probably persist as a major health problem in the world, especially in Southeast Asia. We are glad to see that our paper about multibacillary leprosy in a child can be noticed by the readers.展开更多
基金financially supported by the National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China (No.J1103303)the National Natural Science Foundation of China (No.20702005)+2 种基金the Fujian Provincial Department of Science and Technology,China (No.2013Y0062)Funding (Type A) from Fujian Education Department,PR China (Nos.JA12038 and JA13043)the Science and Technology Development Fund of Fuzhou University,China (No.600902)
文摘Due to the high affinity between dithiocarbamate (DTC) and Hg2+, a fluorescent probe based on squaraine chromophore with DTC side arm for Hg2+ via coordination induced deaggregation signaling has been designed and synthesized. Squaraine has a high tendency to aggregate in aqueous solution, and such self-aggregation usually results in a dramatic absorption spectral broadening with fluorescence emission quenching. The combination of the DTC side arm of the probe with Hg2+ induces steric hindrance, leading to the deaggregation of the dye complex, companying with a fluorescence emission restoration. In EtOH-H2O (20:80, v/v) solution, this "turn on" fluorescent probe has high selectivity and sensitivity toward Hg2+ over other metal ions, and the limit of detection for Hg2+ was estimated as 2.19 × 10^-8 mol/L by 3σ/k.
文摘To the Editor: A 12-year-old boy born in Guizhou Province, China, presented with a history of generalized raised nodular lesions developing over the course of 2 months on the face and limbs. The patient's first symptom was the appearance of small nodules on the face, unaccompanied by sensations of itching, pain, or burning.
文摘Thanks for your careful reading and priceless comments to our recent publication.N Although the incidence and prevalence of leprosy have declined significantly in recent decades, leprosy will probably persist as a major health problem in the world, especially in Southeast Asia. We are glad to see that our paper about multibacillary leprosy in a child can be noticed by the readers.