Myotonic dystrophy （DM） is a chronic, slowly progressing, highly variable, inherited multisystemic disease, which includes two main types： DM type 1 （DM1） and DM type 2 （DM2）. Both DM 1 and DM2 are autosomal do...Myotonic dystrophy （DM） is a chronic, slowly progressing, highly variable, inherited multisystemic disease, which includes two main types： DM type 1 （DM1） and DM type 2 （DM2）. Both DM 1 and DM2 are autosomal dominantly inherited disorder. DM1, also called Steinert disease, is characterized by myotonia, muscle weakness, muscular dystrophy, endocrinopathy, cataract, cardiac conduction defect, central nervous system （CNS） dysfunction, and so on.展开更多
To the Editor： Parkinson＇s disease （PD） is a common degenerative disease of the central nervous systern （CNS） in middle-aged and elderly people. PD is characterized by resting tremor, myotonia, bradykinesia, abn...To the Editor： Parkinson＇s disease （PD） is a common degenerative disease of the central nervous systern （CNS） in middle-aged and elderly people. PD is characterized by resting tremor, myotonia, bradykinesia, abnormal posture, and gait. The incident of PD increases with age. In addition to motor symptoms, nonmotor symptoms have raised additional concerns in recent years. Cognitive impairment is very common in PD patients. It is estimated that the incidence of PD mild cognitive impairment （PD-MCI） is 20 50%, which is present at the initial visit in some patients and a great number of patients with PD-MCI eventually develop PD with dementia （PDD）.展开更多
文摘Myotonic dystrophy （DM） is a chronic, slowly progressing, highly variable, inherited multisystemic disease, which includes two main types： DM type 1 （DM1） and DM type 2 （DM2）. Both DM 1 and DM2 are autosomal dominantly inherited disorder. DM1, also called Steinert disease, is characterized by myotonia, muscle weakness, muscular dystrophy, endocrinopathy, cataract, cardiac conduction defect, central nervous system （CNS） dysfunction, and so on.
文摘To the Editor： Parkinson＇s disease （PD） is a common degenerative disease of the central nervous systern （CNS） in middle-aged and elderly people. PD is characterized by resting tremor, myotonia, bradykinesia, abnormal posture, and gait. The incident of PD increases with age. In addition to motor symptoms, nonmotor symptoms have raised additional concerns in recent years. Cognitive impairment is very common in PD patients. It is estimated that the incidence of PD mild cognitive impairment （PD-MCI） is 20 50%, which is present at the initial visit in some patients and a great number of patients with PD-MCI eventually develop PD with dementia （PDD）.
