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Effect of pharmacological intervention on MIP-1α,MIP-1β and MCP-1 expression in patients with psoriasis vulgaris 被引量:7
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作者 Yong-Jiang Dai Yu-Yang Li +5 位作者 hui-ming zeng Xiong-An Liang Zhi-Jie Xie Zhi-Ang Zheng Qin-Hui Pan Yi-Xiong Xing 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第7期582-584,共3页
Objective:To detect the expression level of macrophage inflammatory protein-1(MIP-1)α,MIP-1βand monocyte chemoattractant protein-1(MCP-1)in with psoriasis vulgaris and explore the role in the pathogenesis of psorias... Objective:To detect the expression level of macrophage inflammatory protein-1(MIP-1)α,MIP-1βand monocyte chemoattractant protein-1(MCP-1)in with psoriasis vulgaris and explore the role in the pathogenesis of psoriasis vulgaris.Methods:The level of MIP-1α,MIP-1βand MCP-1 in peripheral blood from 50 patients with psoriasis vulgaris and 50 normal controls were measured by enzyme linked immunosorbent assay.The correlation with psoriasis area and severity index(PASI)was analyzed.The level of MIP-1α,MIP-1βand MCP-1 was compared between psoriasis vulgaris patients at active stage and resting stage.And the change in MIP-1α,MIP-1βand MCP-1 before and after therapy was also observed.Results:The content of MIP-1α,MIP-1βand MCP-1 in patients with psoriasis vulgaris was(1342.78±210.30),(175.28±28.18)and(266.86±32.75)ng/L,respectively,significantly higher than those in control group(P<0.05).The expression level of MIP-1α,MIP-1βand MCP-1 in peripheral blood of patients with psoriasis vulgaris was positively correlated wilh PASI(P<0.01).After acitretin therapy,expression level of MIP-1α,MIP-1βand MCP-1 in peripheral blood of patients with psoriasis vulgaris was significantly decreased.Conclusions:Chemokine factor MIP-1α,MIP-1βand MCP-1 may be involved in the pathogenesis of psoriasis vulgaris. 展开更多
关键词 Macrophage inflammatory protein-1 MONOCYTE CHEMOATTRACTANT protein-1 Psoriasis VULGARIS
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Effect of Yinxieling decoction on PASI,TNF-α and IL-8 in patients with psoriasis vulgaris 被引量:4
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作者 Yong-Jiang Dai Yu-Yang Li +5 位作者 hui-ming zeng Xiong-An Liang Zhi-Jie Xie Zhi-Ang Zheng Qin-Hui Pan Yi-Xiong Xing 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第8期668-670,共3页
Objective:To study the effect of Yinxieling decoction on PASI,TNF-α and IL-8 in patients with psoriasis vulgaris.Methods:A total of 120 cases of psoriasis vulgaris were divided into 4 groups according to syndrome dif... Objective:To study the effect of Yinxieling decoction on PASI,TNF-α and IL-8 in patients with psoriasis vulgaris.Methods:A total of 120 cases of psoriasis vulgaris were divided into 4 groups according to syndrome differentiation of TCM and randomized controlled method:wind heat syndrome group(group A).blood stasis syndrome group(group B) blood dryness syndrome group(group C)nd control group(group D)(n=30 per group).Patients in observation groups were treated with Yinxieling decoction,while patients in control group were treated by placebo for 8 weeks.Levels of TNT-α and IL-8 were determined before treatment.4 and 8 weeks after treatment.psoriasis area and severity index score was also performed before and after treatment.Results:psoriasis area and severity index score and serum level of TNF-α,IL-8 were significantly decreased in all groups.The decrease in three observation groups was more significant(P<0.05 or P<0.01),and the decrease in wind heat syndrome group was the most significant(P<0.01).psoriasis area and severity index was positively correlated with TNF-α and IT.-8,respectively(P<0.05).Conclusions:Yinxieling decoction has therapeutical effect on psoriasis vulgaris via regulating TNF-α and IL-8. 展开更多
关键词 Psoriasis vulgaris Yinxieling decoction Syndrome differentiation TNF-Α IL-8
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Effects of abnormal zona pellucida on fertilization and pregnancy in IVF/ICSI-ET 被引量:2
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作者 Jing ZHAO Ning-yuan ZHANG +5 位作者 Zhi-peng XU Lin-jun CHEN Xia ZHAO hui-ming zeng Yi-qun JIANG Hai-xiang SUN 《Journal of Reproduction and Contraception》 CAS CSCD 2015年第2期73-80,共8页
Objective To analyze the fertilization rate, embryo development and clinical outcome of oocytes with abnormal zona pellucida after in vitro fertilization (IVF) or intracytoplasmic sperm injection (1CS1). Methods ... Objective To analyze the fertilization rate, embryo development and clinical outcome of oocytes with abnormal zona pellucida after in vitro fertilization (IVF) or intracytoplasmic sperm injection (1CS1). Methods A retrospective analysis included a total of 43 cycles (27 IVF cycles and 16 ICSI cycles) in which oocytes displaying abnormal zona pellucida were retrieved between January 2006 and December 2011. The fertilization rate, embryo quality, and the cumulative clinical pregnancy rate were analyzed. Results Rescue ICSI was applied in 2 7 IVF cycles in which failed extrusion of the second polar body after conventional IVF was observed, and of them, complete failure to fertilize occurred in 23 IVF cycles. The fertilization rate and the normal fertilization rate for IVF (64.83% and 59.32%, respectively) were significantly lower than those for ICS1 (85.19% and 79.01%, respectively), whereas the cleavage rate (94.12%) with IVF did not differ significantly from that with ICSI (95.65%, P〉0. 05). The percentages of good-quality embryos in 1VF group (52. 67%) and 1CSl group (43.75%) also did not differ significantly (P〉0.05). Although the rates of implantation and pregnancy appeared to be greater in IVF group (33.33% and 40.00%, respectively) compared with those in ICSI group (25.00% and 35. 71%, respectively), the differences were not significant (P〉0.05).Conclusions ICSI should be carried out for oocytes with abnormal zona pellucida, for which the risk of lVF failure is high. Rescue ICSI improves the likelihood of fertilization of oocytes with abnormal zona pellucida, but cannot improve the clinical outcome. 展开更多
关键词 abnormal zona pellucida FERTILIZATION development of embryo clinical pregnancy
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