The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has posed severe threats to human health,public safety,and the global economy.Metal nutrient elements can dir...The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has posed severe threats to human health,public safety,and the global economy.Metal nutrient elements can directly or indirectly take part in human immune responses,and metal-related drugs have served as antiviral drugs and/or enzyme inhibitors for many years,providing potential solutions to the prevention and treatment of COVID-19.Metal-based drugs are currently under a variety of chemical structures and exhibit wide-range bio activities,demonstrating irreplaceable advantages in pharmacology.This review is an intention to summarize recent progress in the prevention and treatment strategies against COVID-19 from the perspective of metal pharmacology.The current and potential utilization of metal-based drugs is briefly introduced.Specifically,metallohydrogels that have been shown to present superior antiviral activities are stressed in the paper as potential drugs for the treatment of COVID-19.展开更多
基金Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Sciencethe National Natural Science Foundation of China(Nos.21773311 and 21972169)Hunan Provincial Science and Technology Plan Project,China(No.2019TP1001)。
文摘The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has posed severe threats to human health,public safety,and the global economy.Metal nutrient elements can directly or indirectly take part in human immune responses,and metal-related drugs have served as antiviral drugs and/or enzyme inhibitors for many years,providing potential solutions to the prevention and treatment of COVID-19.Metal-based drugs are currently under a variety of chemical structures and exhibit wide-range bio activities,demonstrating irreplaceable advantages in pharmacology.This review is an intention to summarize recent progress in the prevention and treatment strategies against COVID-19 from the perspective of metal pharmacology.The current and potential utilization of metal-based drugs is briefly introduced.Specifically,metallohydrogels that have been shown to present superior antiviral activities are stressed in the paper as potential drugs for the treatment of COVID-19.
