BACKGROUND Grade II and III meningiomas[World Health Organization(WHO)classification]rarely have extracranial metastases via the blood circulation;however,we experienced a case with a metaplastic atypical meningioma a...BACKGROUND Grade II and III meningiomas[World Health Organization(WHO)classification]rarely have extracranial metastases via the blood circulation;however,we experienced a case with a metaplastic atypical meningioma and local dedifferentiation that metastasized to the jugular vein,carotid artery and subclavian artery at the cervicothoracic junction.Such cases have seldom been reported before.CASE SUMMARY The patient was a 30-year-old man who developed right neck masses with dysphagia,labored breathing,dizziness,and occasional earaches.Eight months earlier the patient was diagnosed with a right parietal lobe neoplasm and hemorrhage at a local hospital due to the sudden onset of headaches and left limb weakness,and the post-operative pathology was a metaplastic atypical meningioma(WHO grade II)with local de-differentiation(WHO III).Magnetic resonance imaging revealed a calcified mass at the root of the neck on the right and a large cystic mass in the right parapharyngeal space.Head and neck angiography showed that the right common carotid artery was compressed and completely occluded,and the jugular vein was enveloped by the tumor and occluded.A balloon occlusion test showed no perfusion in the right common carotid artery.Tumor resection,carotid artery ligation,and subclavian artery reconstruction were performed.The tumor was a malignant meningioma.Postoperatively,the patient had Horner's syndrome and hoarseness.CONCLUSION This case highlights the importance of the link between a large cervical mass and a primary intracranial tumor.Malignant meningioma should not be considered merely as an intracranial metastasis spread through cerebrospinal fluid,it can also be transferred through the circulation to the parapharyngeal space and the cervical great vessels.展开更多
Objective:To investigate the influences of TimeSlips on the Cornell Scale for Depression in Dementia(CSDD)scores of mild or moderate senile dementia patients.Methods:Forty-three cases of mild or moderate senile dement...Objective:To investigate the influences of TimeSlips on the Cornell Scale for Depression in Dementia(CSDD)scores of mild or moderate senile dementia patients.Methods:Forty-three cases of mild or moderate senile dementia patients were selected locally for convenience sake and given the TimeSlips intervention.The patients were assessed using the scales of CSDD and the Observed Emotion Rating Scale(OERS).Results:The differences of the patients'CSDD scores between before and after the intervention were statistically significant(P<0.05).The differences of the patients'OERS scores on positive and negative emotions between before and after the intervention were also statistically significant(P<0.05).Conclusion:TimeSlips is beneficial to relieve depressive symptoms and ameliorate the emotions of mild or moderate senile dementia patients,thus improving their life quality and reducing the burden of their caregivers.A large-scale experimental research on TimeSlips with rigorous design is proposed for further studies.展开更多
Background:Visceral leishmaniasis(VL)was one of the most important parasitic diseases in China,caused by Leishmania protozoans and transmitted by sand flies.Recently VL cases have reappeared in China,including the ext...Background:Visceral leishmaniasis(VL)was one of the most important parasitic diseases in China,caused by Leishmania protozoans and transmitted by sand flies.Recently VL cases have reappeared in China,including the extension region of the Loess Plateau.The purpose of this study was to collect fundamental data on the host-vector VL system in the Loess Plateau to assist in the development of prevention and control measures.Methods:Sand flies were collected by light traps from rural areas in Shanxian,Henan,China in 2015,as well as in Wuxiang and Yangquan,Shanxi,China in 2017.The blood sources of sand flies were analyzed by PCR detecting the host-specific mitochondrial cytochrome b(mtDNA cyt b)gene fragments.Leishmania infection in sand flies was detected by amplifying and sequencing ribosomal DNA internal transcribed spacer 1(ITS1).The Leishmania specific antibodies in the sera of local dogs were detected by ELISA kit.Results:Blood sources showed diversity in the extension region of the Loess Plateau,including human,chicken,dog,cattle,pig and goat.Multiple blood sources within a sand fly were observed in samples from Yangquan(17/118,14.4%)and Wuxiang(12/108,11.1%).Leishmania DNA was detected in sand flies collected from Yangquan with minimum infection rate of 1.00%.The ITS1 sequences were conserved with the Leishmania donowni complex.The positive rate of Leishmania specific antibodies in dogs was 5.97%.Conclusions:This study detected the blood sources and Leishmania parasites infection of sand flies by molecular methods in the extension region of Loess Plateau,China.A high epidemic risk of leishmaniasis is currently indicated by the results as the infection of Leishmania in sand flies,the extensive blood sources of sand flies including humans,and positive antibody of Leishmania in local dog sera.Given the recent increase of VL cases,asymptomatic patients,dogs and other potential infected animals should be screened and treated.Furthermore,the density of sand flies needs to be controlled and personal protection should be strengthened.展开更多
文摘BACKGROUND Grade II and III meningiomas[World Health Organization(WHO)classification]rarely have extracranial metastases via the blood circulation;however,we experienced a case with a metaplastic atypical meningioma and local dedifferentiation that metastasized to the jugular vein,carotid artery and subclavian artery at the cervicothoracic junction.Such cases have seldom been reported before.CASE SUMMARY The patient was a 30-year-old man who developed right neck masses with dysphagia,labored breathing,dizziness,and occasional earaches.Eight months earlier the patient was diagnosed with a right parietal lobe neoplasm and hemorrhage at a local hospital due to the sudden onset of headaches and left limb weakness,and the post-operative pathology was a metaplastic atypical meningioma(WHO grade II)with local de-differentiation(WHO III).Magnetic resonance imaging revealed a calcified mass at the root of the neck on the right and a large cystic mass in the right parapharyngeal space.Head and neck angiography showed that the right common carotid artery was compressed and completely occluded,and the jugular vein was enveloped by the tumor and occluded.A balloon occlusion test showed no perfusion in the right common carotid artery.Tumor resection,carotid artery ligation,and subclavian artery reconstruction were performed.The tumor was a malignant meningioma.Postoperatively,the patient had Horner's syndrome and hoarseness.CONCLUSION This case highlights the importance of the link between a large cervical mass and a primary intracranial tumor.Malignant meningioma should not be considered merely as an intracranial metastasis spread through cerebrospinal fluid,it can also be transferred through the circulation to the parapharyngeal space and the cervical great vessels.
基金This project was funded by the key project on social development of Fujian Provincial Department of Science&Technology(2012Y0013),China。
文摘Objective:To investigate the influences of TimeSlips on the Cornell Scale for Depression in Dementia(CSDD)scores of mild or moderate senile dementia patients.Methods:Forty-three cases of mild or moderate senile dementia patients were selected locally for convenience sake and given the TimeSlips intervention.The patients were assessed using the scales of CSDD and the Observed Emotion Rating Scale(OERS).Results:The differences of the patients'CSDD scores between before and after the intervention were statistically significant(P<0.05).The differences of the patients'OERS scores on positive and negative emotions between before and after the intervention were also statistically significant(P<0.05).Conclusion:TimeSlips is beneficial to relieve depressive symptoms and ameliorate the emotions of mild or moderate senile dementia patients,thus improving their life quality and reducing the burden of their caregivers.A large-scale experimental research on TimeSlips with rigorous design is proposed for further studies.
基金This work was supported by National Natural Sciences Foundation of China(No.31970445&81371848)Shanxi Province Science and Technology Department(201803D31205).
文摘Background:Visceral leishmaniasis(VL)was one of the most important parasitic diseases in China,caused by Leishmania protozoans and transmitted by sand flies.Recently VL cases have reappeared in China,including the extension region of the Loess Plateau.The purpose of this study was to collect fundamental data on the host-vector VL system in the Loess Plateau to assist in the development of prevention and control measures.Methods:Sand flies were collected by light traps from rural areas in Shanxian,Henan,China in 2015,as well as in Wuxiang and Yangquan,Shanxi,China in 2017.The blood sources of sand flies were analyzed by PCR detecting the host-specific mitochondrial cytochrome b(mtDNA cyt b)gene fragments.Leishmania infection in sand flies was detected by amplifying and sequencing ribosomal DNA internal transcribed spacer 1(ITS1).The Leishmania specific antibodies in the sera of local dogs were detected by ELISA kit.Results:Blood sources showed diversity in the extension region of the Loess Plateau,including human,chicken,dog,cattle,pig and goat.Multiple blood sources within a sand fly were observed in samples from Yangquan(17/118,14.4%)and Wuxiang(12/108,11.1%).Leishmania DNA was detected in sand flies collected from Yangquan with minimum infection rate of 1.00%.The ITS1 sequences were conserved with the Leishmania donowni complex.The positive rate of Leishmania specific antibodies in dogs was 5.97%.Conclusions:This study detected the blood sources and Leishmania parasites infection of sand flies by molecular methods in the extension region of Loess Plateau,China.A high epidemic risk of leishmaniasis is currently indicated by the results as the infection of Leishmania in sand flies,the extensive blood sources of sand flies including humans,and positive antibody of Leishmania in local dog sera.Given the recent increase of VL cases,asymptomatic patients,dogs and other potential infected animals should be screened and treated.Furthermore,the density of sand flies needs to be controlled and personal protection should be strengthened.
